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The Antarctic Circumpolar Current (ACC) since the Last Interglacial is reconstructed, showing orbital-scale shifts in ACC position driven by eccentricity and precession, possibly counteracting the predicted southward shift due to global warming.

Scaffolding protein ankyrin-B, implicated in cardiometabolic syndrome, enables mitochondrial fission and flexibility of nutrient utilization under energetic stress in skeletal muscle to support energy production and optimal exercise capacity.

Beading combines soft, compliant threads with discrete, rigid elements to make architected materials. Here, authors show how geometry, tension, and friction together enable programmable shape and tunable mechanical behavior.

The spatial organization of a tumor affects how it grows and responds to treatment. Here, the authors present VALIS, a software to align sets of whole slide images (WSI) with state-of-the-art accuracy, enabling spatial studies of the tumor ecology.

Introducing spin–orbit coupling by substrate proximity effect leads to an enhancement of superconducting phases in rhombohedral trilayer graphene.

Novel biochemical processes using magnetic particles have been automated to provide a robotic system to perform processes for large-scale shotgun sequencing.

A new high-resolution record for the Antarctic Zone shows persistent anti-phasing of high interglacial ocean productivity and high glacial dust deposition, suggesting a close inter-hemispheric coupling of cryosphere, ocean and atmosphere.

Photoluminescence and photocurrent measurements indicate that MoSe₂/WS₂ hetero-bilayers can be switched from type-I to type-II band alignment by applying a vertical electric field.

Few palaeoclimate archives beyond the polar regions preserve continuous and datable paleotemperature proxy time series over multiple glacial-interglacial cycles. Here, the authors show that Mg concentrations in a subaqueous speleothem from an Italian cave track regional sea-surface temperatures over the last 350,000 years.

Geometric packing of tubules in the developing kidney urinary collecting system leads to tissue stiffening and rhythmic mechanical stresses local to nephron-forming niches that synchronize with tubule branching.

HLA peptidomic analysis identifies recurrent intracellular bacteria-derived peptides presented on HLA-I and HLA-II molecules in melanoma tumours, revealing how bacteria can modulate immune functions and responses to cancer therapies.

Schwaller et al. show that the USH2A protein, present in Meissner’s corpuscles, is necessary in humans and mice to perceive tiny vibrations. USH2A may facilitate force transfer to mechanoreceptors as the fingertip probes rough surfaces.

Peptide nucleic acids can self-assemble into ordered architectures that are coordinated by both stacking interactions and Watson–Crick base pairing, and exhibit a variety of optical properties.

TRAAK, TREK-1 and TREK-2 are mechanosensitive potassium channels involved in action potential propagation among other roles. Here, authors quantify their tension response and show ultrasound can generate tension to activate ion channels.

The actin cytoskeleton is built from actin monomers encoded by seven almost identical genes. Here, the authors show that individual actin isoforms cannot substitute for each other and make specialized contributions to cell division.

A device architecture based on indium arsenide–aluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error probability of 1%.

Sedimentary ancient DNA can indicate ecosystem-wide changes. Here, the authors show association between warm phases and high diatom abundance in the Antarctic Scotia Sea, in addition to presenting ancient eukaryote sedimentary DNA spanning the last approximately 1 million years.

AlphaFold predicts protein structures with an accuracy competitive with experimental structures in the majority of cases using a novel deep learning architecture.

During cell division, the actin cytoskeletal network at both the equatorial contractile ring and cell cortex are known to play a role, but the regulation of γ-actin during cytokinesis is less well understood. Here, the authors show that recruitment of β-actin to the contractile ring and loss of γ-actin from the cell poles is required for completion of cell division.

Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca²⁺ flux upon target recognition and NK cell activation.

The extrusion of large extracellular vesicles is an important mechanism that facilitates cell-to-cell communication and maintains homoeostasis. Here, Atkin-Smith et al. use intravital microscopy to directly visualize the formation of large extracellular vesicles in bone marrow.

Large scale suspension fermentation technology is not easily portable or reusable. Here the authors describe a hydrogel system suitable for long-term and reusable production with both single and multi-organism consortia.

Analysis of live-cell imaging and single-cell genome sequencing data of colorectal cancer organoids identifies temporal dynamics of sub-chromosomal copy-number amplifications.

Developmental and epileptic encephalopathies are devastating neurological disorders. Here, the authors establish a cohort of patients with variants in the gene DENND5A and use human stem cells to discover a disease mechanism involving altered cell division.

Trevor Cannon and colleagues evaluate the impact of a carbon-free, ammonia-powered propulsion system on contrail formation during flight. The report suggests that there are benefits compared to the use of conventional jet fuel from reduced soot formation. However, the increased critical temperatures caused by burning ammonia result could lead to increased volumes of more enduring contrails at lower altitudes.

Methods that analyze intra-tumor genetic heterogeneity often do not preserve the spatial context of tumor subclones. Here, the authors present BaseScope, a mutation-specific RNA in situ hybridization assay and spatially map colorectal cancer and adenoma KRAS, BRAF and PIK3CA driver gene mutant subclones.

Gaussian boson sampling is performed on 216 squeezed modes entangled with three-dimensional connectivity⁵, using Borealis, registering events with up to 219 photons and a mean photon number of 125.

Expression of α6 integrin enables acute lymphoblastic leukaemia cells to use neural migratory pathways to invade the central nervous system and metastasize to the brain.

Polymeric nanocarriers used for drug delivery are often coated by albumin in vivo influencing the therapeutic outcomes. Here, the authors engineer the surface chemistry of a nanocarrier to either stabilize or denature the structure of adsorbed albumin, resulting in evasion or clearance by macrophages.

Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors for metabolic syndrome and diabetes.

The East Antarctic ice sheet is considered to be largely insensitive to temperature changes in the Southern Ocean. Marine sediment records indicate the East Antarctic ice sheet repeatedly retreated by several hundred kilometres during intervals of Pliocene warmth.

Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the positive transcription elongation factor (P-TEFb).

Structural and functional studies reveal how viral proteins trigger the phage antirestriction induced system (PARIS) to degrade host tRNA and how viral tRNAs suppress the PARIS nuclease and thereby overcome this phage defense system.

Rebound potentiation (RP), a form of inhibitory plasticity in the cerebellum, is characterized by an increase in GABAergic synaptic currents. Here the authors demonstrate that RP is both interneuron input-specific and GABA_Areceptor subunit-specific and serves to regulate Purkinje cell firing patterns.

Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.

The OTU domain deubiquitinase TRABID specifically hydrolyzes atypical Lys29- and Lys33-linked diubiquitin chains. Structural analysis of TRABID reveals an unpredicted ankyrin-repeat domain that binds ubiquitin and is crucial for TRABID efficiency and linkage specificity in vitro and in vivo.

Bick et al. describe a novel way of testing their hypothesis that an invasive predatory snail fails to drive to extinction a native, threatened non-predatory snail because both have different tolerance ranges for exposure to sunlight. They test it by developing a miniature light sensor, small enough to be carried by these snails on their shells.

Accelerated atherosclerosis in a mouse model of clonal haematopoiesis is prevented by genetic interruption of AIM2 inflammasome activation or by inhibition of interleukin-1β.

A Study Identifies Broad-Spectrum Pan-Coronavirus Antiviral Drugs Targeting Host Protein Quality Control Mechanisms And Reports Development Of A Bsl2-Level Cell-Integrated Sars-Cov-2 Replicon, Which Can Be Used For High-Throughput Screening.