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Showing 1–50 of 182 results
Advanced filters: Author: Vincent H. M. Tang Clear advanced filters
  • In the CheckMate 142 study, nivolumab (anti-PD-1) alone and in combination with ipilimumab (anti-CTLA-4) was shown to induce durable clinical benefit in patients with previously treated microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer. Here, the authors perform exploratory biomarker analysis of the CheckMate 142 study.

    • Ming Lei
    • Michael J. Overman
    • Scott Kopetz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Self-intercalated Chromium tellurides consist of CrTe2 van der Waals layers, with additional Chromium atoms residing in the van der Waals gap. This highly tuneable class of magnetic materials has presented a range of unique magnetic phenomena, and here Bigi, Jego, Polewczyk et al add to this by showing that CrTe2 (δ = 0.25 − 0.50) hosts orthogonal ferromagnetism.

    • Chiara Bigi
    • Cyriack Jego
    • Federico Mazzola
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • Cold atoms inertial sensors offer great precision and sensitivity, yet their use in mobile applications has been hindered by the effects of rotations on their measurements. Here, authors demonstrate an atom interferometer operating over a wide range of orientations and rotation rates, thanks to hybridisation with accelerometers and gyroscopes.

    • Quentin d’Armagnac de Castanet
    • Cyrille Des Cognets
    • Baptiste Battelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9
  • Using ethnically and geographically diverse metagenomic data, the authors identify microbiota alterations associated with inflammatory bowel disease (IBD). They discover universal IBD-associated bacteria, which serve as the basis for a multibacteria biomarker panel that could support a noninvasive tool for IBD diagnosis.

    • Jiaying Zheng
    • Qianru Sun
    • Siew C. Ng
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 3555-3567
  • Intracellular biothiols can degrade nanoparticle monolayers, compromising the function of these potentially promising tools. Here, we describe a label-free method for quantifying the intracellular stability of quantum dot monolayers, using laser desorption/ionization mass spectrometry coupled with inductively coupled plasma mass spectrometry.

    • Zheng-Jiang Zhu
    • Yi-Cheun Yeh
    • Vincent M. Rotello
    Research
    Nature Chemistry
    Volume: 3, P: 963-968
  • Khufu’s Pyramid is one of the largest archaeological monuments in the world, and still contains unexplored voids. Here, the authors use cosmic-ray muon radiography in multiple positions to precisely characterize one of these inner structures called the North Face Corridor.

    • Sébastien Procureur
    • Kunihiro Morishima
    • Mohamed Elkarmoty
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

    • R. Aaij
    • A. S. W. Abdelmotteleb
    • G. Zunica
    ResearchOpen Access
    Nature
    Volume: 643, P: 1223-1228
  • Bacteria can use different mechanisms to become resistant to the same antibiotic class. Here, the authors study bacterial strains that express genes conferring tetracycline resistance via different mechanisms, and find that each mechanism is preferentially selected for by specific tetracycline generations.

    • Kevin S. Blake
    • Yao-Peng Xue
    • Gautam Dantas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Trained on large and multicenter datasets with different imaging modalities, a foundation model is shown to have strong performance on the full spectrum of clinically relevant tasks and to increase user accuracy in diagnostic tasks.

    • Siyuan Yan
    • Zhen Yu
    • Zongyuan Ge
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2691-2702
  • Protein and RNA-based condensates have emerged as biologically important alternatives to classical membrane-bound organelles. Here the authors design pure RNA condensates from nanostructured, star-shaped RNA motifs, and engineer them to recruit specific peptides and proteins.

    • Jaimie Marie Stewart
    • Shiyi Li
    • Elisa Franco
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

    • Declan L. M. Cooper
    • Simon L. Lewis
    • Stanford Zent
    ResearchOpen Access
    Nature
    Volume: 625, P: 728-734
  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712
  • Small molecule antagonists of CCR6 are potential drugs for autoimmune disorders. Here the authors present inactive structures of CCR6 bound by different allosteric antagonists from two series simultaneously, offering multiple approaches to inhibit CCR6.

    • David Jonathan Wasilko
    • Brian S. Gerstenberger
    • Huixian Wu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Magnetic resonance imaging is a promising non-invasive approach to visualize paramagnetic materials in devices, but the short lifetime of signals currently limits its use. Here, the authors develop an approach which overcomes this hurdle to spectroscopically image lithiation fronts during battery operation.

    • Mingxue Tang
    • Vincent Sarou-Kanian
    • Elodie Salager
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • This study assesses the protective capacity of mangroves by incorporating their width,

    height, and health. It reveals that while mangrove area remained relatively stable, the

    coastal protection capacity declined by 25% from 2007 to 2019 due to significant

    decreases in height and biomass. This decline poses risks for coastal regions,

    particularly those vulnerable to climate change and human activities. These findings

    underscore the urgent need for enhanced conservation efforts to preserve mangrove

    ecosystems and their protective functions.

    • Xichen Xu
    • Dongjie Fu
    • Juan Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103
  • Even evergreen tropical forests can have seasonal dynamics, which may be sensitive to disturbance. Here, the authors combine high-resolution remote sensing observations and microclimate data to show that forest fragmentation impacts canopy phenology dynamics in the Amazon forest.

    • Matheus Henrique Nunes
    • José Luís Campana Camargo
    • Eduardo Eiji Maeda
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10
  • Behavioural experiments to study decision-making in response to context-dependent accumulation of evidence provide testable models that are consistent with the heterogeneity in neural signatures among rats that perform well in trials.

    • Marino Pagan
    • Vincent D. Tang
    • Carlos D. Brody
    ResearchOpen Access
    Nature
    Volume: 639, P: 421-429
  • Authors perform an analysis of the patient data and risk factors to evaluate unfavorable outcomes and adverse events in adults with pulmonary tuberculosis treated with a 4-month rifapentine based regimen. Low rifapentine exposure was the most clinically significant risk factor for treatment failure and tuberculosis relapse.

    • Vincent K. Chang
    • Marjorie Z. Imperial
    • Elizabeth Guy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

    • Shuofeng Yuan
    • Xin Yin
    • Kwok-Yung Yuen
    Research
    Nature
    Volume: 593, P: 418-423
  • The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

    • Daniel Taliun
    • Daniel N. Harris
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 590, P: 290-299
  • White matter hyperintensities are linked to cortical atrophy, a key feature in dementia. Here, the authors identify loci associated with cortical atrophy related to white matter hyperintensities, which involve vascular and neuronal processes.

    • Yash Patel
    • Jean Shin
    • Zdenka Pausova
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • This work describes scEdU-seq for studying replication fork speed in single cells, which enables researchers to investigate variability in replication speed along S phase and its associations with transcription and DNA damage.

    • Jeroen van den Berg
    • Vincent van Batenburg
    • Alexander van Oudenaarden
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1175-1184
  • Type 2 inflammation drives the formation of pathologic mucus in patients with asthma. Here, authors reveal a role for intelectin-1 in IL-13-induced mucus properties, and that an ITLN1 eQTL is associated with protection from the formation of mucus plugs in T2-high asthma.

    • Jamie L. Everman
    • Satria P. Sajuthi
    • Max A. Seibold
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19
  • SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

    • Biao Zhou
    • Runhong Zhou
    • Zhiwei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14
  • Comparative RNA-seq, ChIP–seq and quantitative phosphoproteomics reveal how the blast fungus uses the Pmk1 MAP kinase to regulate a network of transcription factors that orchestrate the complex transcriptome changes necessary for infecting rice plants.

    • Míriam Osés-Ruiz
    • Neftaly Cruz-Mireles
    • Nicholas J. Talbot
    Research
    Nature Microbiology
    Volume: 6, P: 1383-1397
  • A whole-genome sequencing analysis of 100 pancreatic ductal adenocarcinomas has discovered known and newly identified genetic drivers of pancreatic cancer; these genetic alterations can be classified into four subtypes, which raises the possibility of improved targeting of clinical treatments.

    • Nicola Waddell
    • Marina Pajic
    • Sean M. Grimmond
    Research
    Nature
    Volume: 518, P: 495-501
  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763
  • Ordovas-Montanes and colleagues describe the composition of the nasal cellular ecosystem and signatures of disease severity in vaccinated and unvaccinated adults during infection with the ancestral, Delta and Omicron variants of SARS-CoV-2.

    • Jaclyn M. L. Walsh
    • Vincent N. Miao
    • Jose Ordovas-Montanes
    Research
    Nature Immunology
    Volume: 26, P: 294-307
  • Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.

    • Shuofeng Yuan
    • Hin Chu
    • Kwok-Yung Yuen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15
  • A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

    • Aniket Mishra
    • Rainer Malik
    • Stephanie Debette
    ResearchOpen Access
    Nature
    Volume: 611, P: 115-123
  • Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

    • Stig E Bojesen
    • Karen A Pooley
    • Alison M Dunning
    Research
    Nature Genetics
    Volume: 45, P: 371-384
  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16