Nature Search

Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin

David J. Grainger
Lalage Wakefield
James C. Metcalfe
Research01 Sept 1995
Nature Medicine

Volume: 1, P: 932-937
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Alessandra Eva
Keith C. Robbins
Stuart A. Aaronson
Research14 Jan 1982
Nature

Volume: 295, P: 116-119
Central control of dynamic gene circuits governs T cell rest and activation

Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.

Maya M. Arce
Jennifer M. Umhoefer
Alexander Marson
ResearchOpen Access11 Dec 2024
Nature

Volume: 637, P: 930-939
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

The authors present the largest genome-wide association study to date for a rare Parkinsonian disorder, progressive supranuclear palsy (PSP). They include follow-up investigations of the identified susceptibility loci, functional consequences, and cell-specific pathologies, providing insights into genetic and molecular mechanisms underlying PSP.

Kurt Farrell
Jack Humphrey
Adam Naj
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Random Close Packing and the Heats of Fusion of Simple Liquids

J. L. FINNEY
J. D. BERNAL
Research01 Mar 1967
Nature

Volume: 213, P: 1079-1082
An infection-induced oxidation site regulates legumain processing and tumor growth

Chemical proteomics analysis of human gastric cells revealed that infection with the stomach bacterium Helicobacter pylori decreases reactivity of legumain Cys219, which alters legumain processing and promotes xenograft tumor growth.

Yekaterina Kovalyova
Daniel W. Bak
Stavroula K. Hatzios
Research24 Mar 2022
Nature Chemical Biology

Volume: 18, P: 698-705
Murine maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehaviour

Malnutrition during pregnancy has lasting effects on maternal and offspring health. Its adverse impacts are modified by the maternal microbiome and attenuated by gestational treatment with select microbial metabolites.

Elena J. Coley-O’Rourke
Gregory R. Lum
Elaine Y. Hsiao
Research13 Jun 2025
Nature Microbiology

Volume: 10, P: 1648-1664
An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing

The human ADAR enzyme can deaminate additional transcripts for therapeutic A-to-G RNA base editing using an antisense guide RNA. Here, authors engineer a universal guide RNA scaffold from the U7 snRNA, boosting editing efficiency from minimal doses, especially in organs with limited AAV delivery.

Susan M. Byrne
Stephen M. Burleigh
Adrian W. Briggs
ResearchOpen Access26 May 2025
Nature Communications

Volume: 16, P: 1-14
Thermophilic Actinomycetes producing Resistant Endospores

T. CROSS
P. D. WALKER
G. W. GOULD
Research01 Oct 1968
Nature

Volume: 220, P: 352-354
Noncanonical inheritance of phenotypic information by protein amyloids

Eroglu et al. describe protein amyloid structures that are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. MSTR protein loss results in a transgenerational feminization phenotype through ectopic GLD-1 expression.

Matthew Eroglu
Autumn Zocher
W. Brent Derry
Research02 Sept 2024
Nature Cell Biology

Volume: 26, P: 1712-1724
Reprogramming site-specific retrotransposon activity to new DNA sites

A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large payload insertions.

Christopher W. Fell
Lukas Villiger
Jonathan S. Gootenberg
Research09 Apr 2025
Nature

Volume: 642, P: 1080-1089
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD

This study describes an approach to segment and extract key biophysical parameters from live-cell three-dimensional single-molecule imaging trajectories. The authors use this approach to study how NuRD assembles on chromatin and how it regulates enhancer dynamics.

S. Basu
O. Shukron
E. D. Laue
ResearchOpen Access28 Sept 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1628-1639
Trend of owning the intangible: the mediating role of psychological ownership in cultural consumption within blockchain ecosystems

Ke Xue
Xiaotian Lu
Boyuan Wang
ResearchOpen Access21 Jun 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-14
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

The mechanism of action of artemisinin, an antimalarial drug, is not well understood. Here, the authors use a labelled artemisinin analogue to show that the drug is mainly activated by haem and then binds covalently to over 120 proteins in the malaria parasite, affecting many of its cellular processes.

Jigang Wang
Chong-Jing Zhang
Qingsong Lin
ResearchOpen Access22 Dec 2015
Nature Communications

Volume: 6, P: 1-11
Acetyl-methyllysine marks chromatin at active transcription start sites

Cellular lysine residues can be both methylated and acetylated on the same sidechain to form N^ε-acetyl-N^ε-methyllysine (Kacme), which is found on histone H4 across a range of species and across mammalian tissues and is associated with active chromatin.

William J. Lu-Culligan
Leah J. Connor
Matthew D. Simon
Research20 Sept 2023
Nature

Volume: 622, P: 173-179
Photoelectron spectromicroscopy

G. Beamson
H. Q. Porter
D. W. Turner
Research16 Apr 1981
Nature

Volume: 290, P: 556-561
The role of fatty acid β-oxidation in lymphangiogenesis

The lymphangiogenic factor PROX1 transcriptionally upregulates CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, and this co-regulates lymphatic endothelial cell differentiation by epigenetic control of lymphatic gene expression, demonstrating a role for metabolism in developmental biology.

Brian W. Wong
Xingwu Wang
Peter Carmeliet
Research26 Dec 2016
Nature

Volume: 542, P: 49-54
Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.

Saeed Daneshmandi
Jee Eun Choi
Hemn Mohammadpour
ResearchOpen Access30 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Nanoparticle cellular internalization is not required for RNA delivery to mature plant leaves

A study of gold nanospheres and nanorods shows that, even without internalization, they are very efficient for siRNA delivery and inducing gene silencing in mature plant leaves.

Huan Zhang
Natalie S. Goh
Markita P. Landry
Research22 Nov 2021
Nature Nanotechnology

Volume: 17, P: 197-205
Engineering a genomically recoded organism with one stop codon

Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into proteins.

Michael W. Grome
Michael T. A. Nguyen
Farren J. Isaacs
ResearchOpen Access05 Feb 2025
Nature

Volume: 639, P: 512-521
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

The relationship between lipid dyshomeostasis and tau pathology in FTLD and AD remains unclear. Here, the authors demonstrate that GRAMD1B contributes to lipid dyshomeostasis, autophagy impairment, and tau hyperphosphorylation in neurons.

Diana Acosta Ingram
Emir Turkes
Hongjun Fu
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-24
MEF2C regulates NK cell effector functions through control of lipid metabolism

Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans. This control is exerted via regulation of lipid metabolism, and deficiency in MEF2C can be overcome by oleic acid supplementation.

Joey H. Li
Adalia Zhou
Timothy E. O’Sullivan
Research08 Apr 2024
Nature Immunology

Volume: 25, P: 778-789
A Naturally Occurring Fragment Related to the Heavy Chains of Immunoglobulin G in Normal Human Urine

M. W. TURNER
D. S. ROWE
Research09 Apr 1966
Nature

Volume: 210, P: 130-132
Identifying cell receptors for the nanoparticle protein corona using genome screens

A combination of mass spectrometry, pooled genome screens and STRING analysis identifies key uptake mediating interactions between nanoparticle-adsorbed proteins and cells via the low-density lipoprotein receptor.

Wayne Ngo
Jamie L. Y. Wu
Warren C. W. Chan
Research11 Aug 2022
Nature Chemical Biology

Volume: 18, P: 1023-1031
Growth of complete ammonia oxidizers on guanidine

Nitrospira inopinata and probably most other comammox microorganisms can grow on the non-conventional substrate guanidine as the sole source of energy, reductant and nitrogen.

Marton Palatinszky
Craig W. Herbold
Michael Wagner
ResearchOpen Access14 Aug 2024
Nature

Volume: 633, P: 646-653
Kerguelen hotspot source for Rajmahal Traps and Ninetyeast Ridge?

J. J. Mahoney
J. D. Macdougall
K. Gopalan
Research02 Jun 1983
Nature

Volume: 303, P: 385-389
SV40 Virus-induced Tumour Specific Transplantation Antigen in Cultured Mouse Cells

RICHARD W. SMITH
JOEL MORGANROTH
PETER T. MORA
Research11 Jul 1970
Nature

Volume: 227, P: 141-145
A Possible Galactic Origin for Quasi-stellar Sources

G. J. ODGERS
R. W. STEWART
Research17 Sept 1966
Nature

Volume: 211, P: 1284
Glutamate neurotoxicity and Huntington's chorea

JOHN W. OLNEY
TAISIJA DE GUBAREFF
Research01 Feb 1978
Nature

Volume: 271, P: 557-559
Nucleotides and Adenosine Monophosphate Deaminase Activity of Muscle in Primary Hypokalæmic Periodic Paralysis

ANDREW G. ENGEL
CLARENCE S. POTTER
JOHN W. ROSEVEAR
Research16 May 1964
Nature

Volume: 202, P: 670-672
Lysine catabolism reprograms tumour immunity through histone crotonylation

Glioblastoma stem cells co-opt lysine uptake and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to evade interferon-induced intrinsic effects on glioblastoma stem cell maintenance and extrinsic effects on immune response.

Huairui Yuan
Xujia Wu
Jeremy N. Rich
Research17 May 2023
Nature

Volume: 617, P: 818-826
Inhibition of GPX4 enhances CDK4/6 inhibitor and endocrine therapy activity in breast cancer

While CDK4/6 inhibitors (CDK4/6i) have improved outcomes for breast cancer patients, estrogen receptor (ER + ) breast cancers often develop resistance, and triple negative breast cancer (TNBC) show poor sensitivity. Here, the authors identify a vulnerability of CDK4/6i treated ER+ and TNBC on ferroptosis and identify the combination of CDK4/6i and GPX4 inhibition as synergistic.

M. T. Herrera-Abreu
J. Guan
N. C. Turner
ResearchOpen Access05 Nov 2024
Nature Communications

Volume: 15, P: 1-19
TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux

Garbincius et al. show that the mitochondrial protein TMEM65 is required to mediate NCLX-dependent mitochondrial calcium efflux, thus fine-tuning mitochondrial function and cellular homeostasis

Joanne F. Garbincius
Oniel Salik
John W. Elrod
Research08 Apr 2025
Nature Metabolism

Volume: 7, P: 714-729
Solar modulation of atmospheric electrification and possible implications for the Sun–weather relationship

Ralph Markson
Research11 May 1978
Nature

Volume: 273, P: 103-109
Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myeloma

The mechanisms behind acquired resistance to the proteasome inhibitor bortezomib in multiple myeloma remain to be elucidated. Here, the authors show that the histone methyltransferase NSD2 stabilized SRC-3 protein levels, promotes its phase separation and alters H3K36me2 at certain gene promoters resulting in a transcriptional profile that favors resistance of myeloma cells to bortezomib.

Jing Liu
Ying Xie
Zhiqiang Liu
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

Johannes L. Bos
Deniz Toksoz
Ada C. M. Steenvoorden
Research01 Jun 1985
Nature

Volume: 315, P: 726-730
Relationship between Thymus and Hypophysis

W. PIERPAOLI
E. SORKIN
Research19 Aug 1967
Nature

Volume: 215, P: 834-837
Yeast- and antibody-based tools for studying tryptophan C-mannosylation

An engineered Pichia pastoris strain enables the synthesis of tryptophan C-mannosylated proteins, and selected monoclonal antibodies provide tools for detecting these modified proteins and studying their functions.

Alan John
Michael A. Järvå
Ethan D. Goddard-Borger
Research04 Feb 2021
Nature Chemical Biology

Volume: 17, P: 428-437
Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

Daniel L. Burgess
David C. Kohrman
Miriam H. Meisler
Research01 Aug 1995
Nature Genetics

Volume: 10, P: 461-465
Inducible, pharmacogenetic approaches to the study of learning and memory

Masuo Ohno
Paul W. Frankland
Alcino J. Silva
Research19 Nov 2001
Nature Neuroscience

Volume: 4, P: 1238-1243
Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors

Zhong et al. show that, in response to chimeric antigen receptor (CAR) T cell targeting, solid tumors increase the secretion of small extracellular vesicles carrying tumor antigens that are transferred to CAR T cells, resulting in fratricide and reduced antitumor activity.

Wenqun Zhong
Zhiyuan Qin
Wei Guo
Research15 Apr 2025
Nature Cancer

Volume: 6, P: 1157-1172
α-Globin gene organisation in blacks precludes the severe form of α-thalassaemia

A. M. DOZY
Y. W. KAN
H. M. KOENIG
Research01 Aug 1979
Nature

Volume: 280, P: 605-607
Cooperative nutrient scavenging is an evolutionary advantage in cancer

Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

Gizem Guzelsoy
Setiembre D. Elorza
Carlos Carmona-Fontaine
ResearchOpen Access19 Feb 2025
Nature

Volume: 640, P: 534-542
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies

Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and show it can partially reactivate the virus and make it susceptible to killing by T cells.

Timo W. M. De Groof
Elizabeth G. Elder
Martine J. Smit
ResearchOpen Access21 Jul 2021
Nature Communications

Volume: 12, P: 1-11
Chemical proteomics reveals new targets of cysteine sulfinic acid reductase

An electrophilic diazene probe (DiaAlk) enables capture and proteomic analysis of cysteine S-sulfinylation modifications, thus illuminating dynamic responses to oxidative stress and enabling the identification of new substrates of sulfiredoxin.

Salma Akter
Ling Fu
Kate S. Carroll
Research03 Sept 2018
Nature Chemical Biology

Volume: 14, P: 995-1004
Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1

Yeong-Gwan Park
Xiaohong Zhao
Kent W Hunter
Research04 Sept 2005
Nature Genetics

Volume: 37, P: 1055-1062
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates

Huang et al. developed E3-substrate tagging by ubiquitin biotinylation (E-STUB), a proximity labeling-based method for direct identification of ubiquitylated substrates for a given E3 ligase, providing a useful tool for substrate discovery of targeted protein degradation and the understanding of E3 ligase function.

Hai-Tsang Huang
Ryan J. Lumpkin
William R. Sellers
Research21 Mar 2024
Nature Chemical Biology

Volume: 20, P: 1227-1236
Biosynthesis and Energy Transport by Enzymic Reduction of ‘Onium’ Salts

D. W. WOOLLEY
Research21 Feb 1953
Nature

Volume: 171, P: 323-328
Bradykinin

G. P. LEWIS
Research18 Nov 1961
Nature

Volume: 192, P: 596-599
LY6E is a pan-coronavirus restriction factor in the respiratory tract

A panel of seven conditional Ly6e knockout mice are used to show that Ly6e expression protects the respiratory tract from severe acute respiratory syndrome coronavirus 2 and mouse hepatitis virus infection.

Katrina B. Mar
Alexandra I. Wells
John W. Schoggins
Research13 Jul 2023
Nature Microbiology

Volume: 8, P: 1587-1599

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