Nature Search

DNA2 enables growth by restricting recombination-restarted replication

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, highlighting its essential role in proliferation and growth failure in primordial dwarfism.

Jessica J. R. Hudson
Rowin Appanah
Ulrich Rass
ResearchOpen Access03 Sept 2025
Nature

P: 1-9
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication

Biochemical and cell-based assays reveal that PARP inhibitors impede the maturation of nascent DNA strands during DNA replication, and implicate unligated Okazaki fragments and other nascent strand discontinuities in the cytotoxicity of these anti-cancer compounds.

Alina Vaitsiankova
Kamila Burdova
Keith W. Caldecott
ResearchOpen Access24 Mar 2022
Nature Structural & Molecular Biology

Volume: 29, P: 329-338
KCTD10 is a sensor for co-directional transcription–replication conflicts

KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

Jake A. Kloeber
Bin Chen
Zhenkun Lou
ResearchOpen Access08 Oct 2025
Nature

P: 1-10
Roles for E coli DNA polymerases I, II, and III in DNA replication

Robert C. Tait
Douglas W. Smith
Research10 May 1974
Nature

Volume: 249, P: 116-119
Slow unloading leads to DNA-bound β₂-sliding clamp accumulation in live Escherichia coli cells

DNA replication is accomplished by the replisome, a multi-protein complex that comprises the sliding clamp. Here, Moolman et al. present quantitative and dynamic measurements of the number of β₂-sliding clamps at the single-cell level in live E. colicells to shed light on key aspects of DNA replication.

M. Charl Moolman
Sriram Tiruvadi Krishnan
Nynke H. Dekker
ResearchOpen Access18 Dec 2014
Nature Communications

Volume: 5, P: 1-11
Length of uninterrupted CGG repeats determines instability in the FMR1 gene

Evan E. Eichler
Jeanette J.A. Holden
David L. Nelson
Research01 Sept 1994
Nature Genetics

Volume: 8, P: 88-94
Rough Mutants of Salmonella Typhimurium (3) Enzymatic Synthesis of Nucleotide-Sugar Compounds

HIROSHI NIKAIDO
KISHIKO NIKAIDO
B. A. D. STOCKER
Research28 Mar 1964
Nature

Volume: 201, P: 1301-1302
Demonstration of transformer-based ALBERT model on a 14nm analog AI inference chip

The authors report the implementation of a Transformer-based model on the same architecture used in Large Language Models in a 14nm analog AI accelerator with 35 million Phase Change Memory devices, which achieves near iso-accuracy despite hardware imperfections and noise.

An Chen
Stefano Ambrogio
Geoffrey W. Burr
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-11
‘Unmixing’ of the deep-sea record and the deglacial meltwater spike

W. H. Berger
R. F. Johnson
J. S. Killingley
Research20 Oct 1977
Nature

Volume: 269, P: 661-663
Effect of Actinomycin D on DNA Synthesis in Liver

T. UMEDA
W. E. LYNCH
I. LIEBERMAN
Research17 Aug 1973
Nature

Volume: 244, P: 420-422
Nucleotide Pool of Brewers' Yeast During Growth and Fermentation

G. HARRIS
J. W. DAVIES
R. PARSONS
Research06 Dec 1958
Nature

Volume: 182, P: 1565-1567
Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto
Research10 Sept 2025
Nature

Volume: 646, P: 62-67
Polydeoxynucleotide Intermediates in DNA Replication in Regenerating Liver

K. TSUKADA
T. MORIYAMA
I. LIEBERMAN
Research12 Oct 1968
Nature

Volume: 220, P: 162-164
Polynucleotide Chain Lengths of Rapidly Labelled and Ribosomal RNA of Mammalian Cells and E. coli

W. T. RILEY
Research03 May 1969
Nature

Volume: 222, P: 446-452
Formation of Antibiotics

M. M. DHAR
A. W. KHAN
Research17 Sept 1971
Nature

Volume: 233, P: 182-184
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway

The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.

Joel C. Rosenbaum
Braulio Bonilla
Kara A. Bernstein
ResearchOpen Access05 Aug 2019
Nature Communications

Volume: 10, P: 1-11
High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes

Site-directed seamless modification of bacterial artificial chromosomes is enhanced more than tenfold in efficiency by improving the counterselection step. A set of plasmids and oligonucleotide design software also make this E. coli recombineering approach markedly faster and easier.

Alexander W Bird
Axel Erler
A Francis Stewart
Research04 Dec 2011
Nature Methods

Volume: 9, P: 103-109
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

Structural, enzymatic and cellular target engagement studies reveal the mechanism of action by N-hydroxyurea small molecule inhibitors of the DNA repair enzyme, human flap endonuclease-1 (FEN1) that prevent cleavage of DNA flaps in cancer cells.

Jack C Exell
Mark J Thompson
Jane A Grasby
Research15 Aug 2016
Nature Chemical Biology

Volume: 12, P: 815-821
Variable redundancy in RNA transcripts isolated in S and G₂ phase of the cell cycle of Physarum

H. FOUQUET
H. W. SAUER
Research15 May 1975
Nature

Volume: 255, P: 253-255
Are glycoproteins and glycosaminoglycans components of the eukaryotic genome?

G. S. STEIN
R. M. ROBERTS
D. W. WELCH
Research01 Dec 1975
Nature

Volume: 258, P: 639-641
C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption

Here the authors identify that C16orf72 regulates BRCA1/Senataxin to promote replication fork recovery. These proteins act together in a pathway parallel to PARP1 to suppress R-loop accumulation in response to replication stress and confer resistance to PARP inhibitors.

Abhishek Bharadwaj Sharma
Muhammad Khairul Ramlee
Nicholas D. Lakin
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-15
Rough Mutants of Salmonella Typhimurium (2) Serological and Chemical Investigations

I. BECKMANN
T. V. SUBBAIAH
B. A. D. STOCKER
Research28 Mar 1964
Nature

Volume: 201, P: 1299-1301
Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella

Mycetoma is a chronic granulomatous infection of the subcutaneous tissue, most often caused by the fungal pathogen Madurella mycetomatis. Here, the authors show that iron acquisition pathways in both pathogen and host are upregulated during grain formation in an insect larva infection model.

Imad Abugessaisa
Mickey Konings
Wendy W. J. van de Sande
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.

Hana Hanzlikova
Evgeniia Prokhorova
Keith W. Caldecott
ResearchOpen Access07 Jul 2020
Nature Communications

Volume: 11, P: 1-13
Post-infection genetic resistance to avian lymphoid leukosis resides in B target cell

H. GRAHAM PURCHASE
DOUGLAS G. GILMOUR
W. OKAZAKI
Research03 Nov 1977
Nature

Volume: 270, P: 61-62
Near-infrared optical sensors based on single-walled carbon nanotubes

Paul W. Barone
Seunghyun Baik
Michael S. Strano
Research12 Dec 2004
Nature Materials

Volume: 4, P: 86-92
Chemical Inactivation in vitro of Carbonic Anhydrase by Carcinogenic Substances

N. W. H. ADDINK
L. BASTINGS
Research07 Oct 1967
Nature

Volume: 216, P: 72-73
Concurrent Synthesis of Histone and Deoxyribonucleic Acid in Liver after Partial Hepatectomy

S. TAKAI
T. W. BORUN
I. LIEBERMAN
Research01 Aug 1968
Nature

Volume: 219, P: 860-861
Perturbations in cell cycle progression from radioactive DNA precursors

U. K. EHMANN
J. R. WILLIAMS
J. T. LETT
Research01 Dec 1975
Nature

Volume: 258, P: 633-636
Electrocatalytic oxygen evolution on reactively sputtered electrochromic iridium oxide films

G. Beni
L. M. Schiavone
B. S. Schneider
Research15 Nov 1979
Nature

Volume: 282, P: 281-283
Acetylcholine activation of single muscarinic K⁺ channels in isolated pacemaker cells of the mammalian heart

B. Sakmann
A. Noma
W. Trautwein
Research19 May 1983
Nature

Volume: 303, P: 250-253
Structural basis for broad anti-phage immunity by DISARM

DISARM (Defense Island System Associated with Restriction Modification) systems can provide bacteria with protection against a wide range of phage. Here, Bravo et al. determine cryo-EM structures of the core DISARM complex that shed light onto phage DNA recognition and activation of this widespread defense system.

Jack P. K. Bravo
Cristian Aparicio-Maldonado
David W. Taylor
ResearchOpen Access27 May 2022
Nature Communications

Volume: 13, P: 1-11
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

Yanick J Crow
Andrea Leitch
Andrew P Jackson
Research16 Jul 2006
Nature Genetics

Volume: 38, P: 910-916
Reaction of Ethyl Isocyanide with Haemocyanin

E. J. WOOD
W. H. BANNISTER
Research02 Sept 1967
Nature

Volume: 215, P: 1091
Substrate-specific structural rearrangements of human Dicer

Human Dicer can process long double-stranded RNA and hairpin precursor RNA to yield short interfering RNAs or microRNAs, respectively. EM and single-particle analyses of Dicer–substrate complexes now provide insight into the structural basis of Dicer's substrate preference, implicating RNA structure and cofactors in determining substrate recognition and processing efficiency by Dicer.

David W Taylor
Enbo Ma
Hong-Wei Wang
Research28 Apr 2013
Nature Structural & Molecular Biology

Volume: 20, P: 662-670
Antarctic glaciers export carbon-stabilised iron(II)-rich particles to the surface Southern Ocean

Authors show that Antarctic glaciers deliver high particle loads to the ocean, rich in iron that is potential food for marine algae. Microscopy techniques reveal this iron interacts with carbon. Ocean tracers show this glacial iron reaches far offshore.

Rhiannon L. Jones
Jon R. Hawkings
Amber L. Annett
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-10
RNA polymerase II associates with active genes during DNA replication

Protein complexes containing RNA polymerase II and immature RNA are associated with active genes immediately after replication, suggesting that transmission of active transcriptional states to daughter cells may not require any additional epigenetic bookmarks.

Tyler K. Fenstermaker
Svetlana Petruk
Alexander Mazo
Research19 Jul 2023
Nature

Volume: 620, P: 426-433
Interferon required for Viral Resistance induced by Poly I.poly C

T. W. SCHAFER
R. Z. LOCKART JUN.
Research02 May 1970
Nature

Volume: 226, P: 449-450
Expression of genetic resistance to an oncogenic herpesvirus at the target cell level

W. M. GALLATIN
B. M. LONGENECKER
Research01 Aug 1979
Nature

Volume: 280, P: 587-589
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

ALT cells use an alternative lengthening mechanism of telomeres and bear telomeric DNA damage with increased levels of damage-induced long non-coding RNA. Here the AUs show that antisense oligonucleotides (ASO) targeting such RNAs can induce ALT cancer cells selective cell death.

Ilaria Rosso
Corey Jones-Weinert
Fabrizio d’Adda di Fagagna
ResearchOpen Access04 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Novel cytochrome b system in phagocytic vacuoles of human granulocytes

ANTHONY W. SEGAL
OWEN T. G. JONES
Research30 Nov 1978
Nature

Volume: 276, P: 515-517
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Kathryn Lunetta and colleagues report a meta-analysis of 22 genome-wide association studies for age at menopause. They identify 13 loci newly associated with age at natural menopause, including several candidate genes with roles in DNA repair and immune function.

Lisette Stolk
John R B Perry
Kathryn L Lunetta
Research22 Jan 2012
Nature Genetics

Volume: 44, P: 260-268
STED nanoscopy combined with optical tweezers reveals protein dynamics on densely covered DNA

Single DNA-binding proteins can be tracked on densely covered DNA at high spatial and temporal resolution and in the presence of high protein concentrations by using a technique that combines optical tweezers, confocal fluorescence microscopy and stimulated emission depletion (STED) nanoscopy.

Iddo Heller
Gerrit Sitters
Gijs J L Wuite
Research11 Aug 2013
Nature Methods

Volume: 10, P: 910-916
Plant reaction centre defined

M. C. W. Evans
News & Views28 May 1987
Nature

Volume: 327, P: 284-285
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1

Molecular and physiological phenotypes in mouse models of myotonic dystrophy type I can be sustainably reversed by CRISPR-mediated targeting of toxic RNA repeats.

Ranjan Batra
David A. Nelles
Gene W. Yeo
Research14 Sept 2020
Nature Biomedical Engineering

Volume: 5, P: 157-168
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Proteomic definition of the telomeric PARylome combined with genetic and histone H3.3 deposition assays at telomeres reveals that PAR-regulated HIRA activity compensates for loss of ATRX in ALT cells.

Song My Hoang
Nicole Kaminski
Roderick J. O’Sullivan
Research12 Oct 2020
Nature Structural & Molecular Biology

Volume: 27, P: 1152-1164
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
Steering perovskite precursor solutions for multijunction photovoltaics

Understanding the chemistry of perovskite precursor solutions enables improved film optoelectronic properties, allowing the fabrication of multijunction solar cells achieving power conversion efficiencies beyond the radiative limit of single-junction cells.

Shuaifeng Hu
Junke Wang
Henry J. Snaith
ResearchOpen Access23 Dec 2024
Nature

Volume: 639, P: 93-101
Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA

MICHAEL W. DAVIDSON
BILLY G. GRIGGS JR
W. DAVID WILSON
Research01 Apr 1975
Nature

Volume: 254, P: 632-634
γ-Interferon is one of several direct B cell-maturing lymphokines

Charles L. Sidman
Jan D. Marshall
Howard M. Johnson
Research28 Jun 1984
Nature

Volume: 309, P: 801-804

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