The costimulatory molecule CD40 expressed on B cells has an important role in B cell-mediated immunity but some aspects of CD40-mediated signalling remain unknown. Here the authors show that the ubiquitin ligase NEDD4 is a part of a CD40 signalling complex required for CD40-induced Akt activation.
- Di-Feng Fang
- Kun He
- Wei-Hua Li
