Nature Search

Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice

Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.

Jae Sook Kang
Jung Ha Kim
Yong Ryoul Yang
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-20
Diagnostic accuracy and predictors of alpha-synuclein accumulation in the gastrointestinal tract of Parkinson’s disease

Chaewon Shin
Seong-Ik Kim
Beomseok Jeon
ResearchOpen Access15 Aug 2024
npj Parkinson's Disease

Volume: 10, P: 1-9
Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation

Using evoked and resting-state fMRI, the effects of isolation and enrichment housing on sensory development in male mice were tested. Enrichment improved sensorimotor responses, while isolation impaired network segregation and olfactory function.

Taeyi You
Taekwan Lee
Jung Hee Lee
ResearchOpen Access31 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Profiling of protein–protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors

The characterization of protein–protein interactions by combined single-molecule pull-down and single-molecule co-immunoprecipitation assays uncovers, for specific cancers, their dependence on signalling complexes of the human epidermal growth-factor receptor.

Hong-Won Lee
Byoungsan Choi
Tae-Young Yoon
Research02 Apr 2018
Nature Biomedical Engineering

Volume: 2, P: 239-253
A molecular design principle of lyotropic liquid-crystalline conjugated polymers with directed alignment capability for plastic electronics

The molecular alignment and order of conjugated polymers within organic electronic devices is an important consideration for the enhancement of device performance. Now, some design rules are revealed that promote the directed alignment of the polymers and result in the fabrication of well-aligned films with highly anisotropic carrier mobilities.

Bong-Gi Kim
Eun Jeong Jeong
Jinsang Kim
Research24 Mar 2013
Nature Materials

Volume: 12, P: 659-664
Non-invasive optical control of endogenous Ca²⁺ channels in awake mice

Optogenetic applications in the brain of live animals often require the use of optic fibers due to poor tissue-penetration of blue light. Here the authors present monSTIM1, an improved high sensitivity optogenetic tool able to modulate Ca²⁺ signaling in the brain of awake mice using non-invasive light stimulation.

Sungsoo Kim
Taeyoon Kyung
Won Do Heo
ResearchOpen Access10 Jan 2020
Nature Communications

Volume: 11, P: 1-10
Kinetically controlled metal-elastomer nanophases for environmentally resilient stretchable electronics

Metal-elastomer nanophases are critical for stretchable electronics but face mixing challenges. This study introduces a kinetic method for precise mixing, yielding gyrified nanophases with improved durability and strain-invariant conductivity, which holds promise for resilient stretchable devices.

Soosang Chae
Won Jin Choi
Tae Il Lee
ResearchOpen Access09 Apr 2024
Nature Communications

Volume: 15, P: 1-12
Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells

Ji Hyun Kang
Youn Hee Park
Won Jung Lee
ResearchOpen Access01 Dec 2003
Experimental & Molecular Medicine

Volume: 35, P: 467-474
A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus

How the circadian clock generates rhythms of arousal remains unclear. Here, authors show that a clock-output molecule reduces excitability of an arousal circuit during the active phase. These results suggest a multifaceted role for the clock in arousal.

Qiang Liu
Benjamin J. Bell
Mark N. Wu
ResearchOpen Access11 Oct 2023
Nature Communications

Volume: 14, P: 1-14
AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells

Chung Hee Baek
Hyosang Kim
Won Seok Yang
ResearchOpen Access03 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
New polyp image classification technique using transfer learning of network-in-network structure in endoscopic images

Young Jae Kim
Jang Pyo Bae
Yoon Jae Kim
ResearchOpen Access11 Feb 2021
Scientific Reports

Volume: 11, P: 1-8
Clade-specific extracellular vesicles from Akkermansia muciniphila mediate competitive colonization via direct inhibition and immune stimulation

Akkermansia muciniphila has several clades (AmI-AmIV), with one clade usually dominating per host. Here, the authors show AmII-derived extracellular vesicles mediate competitive exclusion of AmI via direct inhibition and immune stimulation.

Moon-Gi Hong
Eun-Ji Song
Young-Do Nam
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial

As presented at the 2025 ASCO GI Cancers Symposium: in the phase 3 BREAKWATER trial, patients with previously untreated BRAF V600E metastatic colorectal cancer received the BRAF inhibitor encorafenib, the anti-EGFR monoclonal antibody cetuximab and chemotherapy mFOLFOX6 versus investigator’s choice of chemotherapy with or without bevacizumab, leading to an improved objective response rate, with the dual primary endpoint of progression free survival still maturing.

Scott Kopetz
Takayuki Yoshino
Josep Tabernero
ResearchOpen Access25 Jan 2025
Nature Medicine

Volume: 31, P: 901-908
Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration

A soft artificial retina with flexible phototransistors and three-dimensional liquid-metal microelectrodes is used to enhance proximity to retinal ganglion cells and minimize damage to soft tissue as well as improve charge injection for vision restoration in retinal degenerative in vivo models.

Won Gi Chung
Jiuk Jang
Jang-Ung Park
ResearchOpen Access15 Jan 2024
Nature Nanotechnology

Volume: 19, P: 688-697
A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

A new population of dysfunctional astrocytes in the aging mouse hippocampus called autophagy-dysregulated astrocytes (APDAs) show impaired protein homeostasis and defective regulation of synapse formation and elimination and appear early in a mouse model of Alzheimer’s disease.

Eunbeol Lee
Yeon-Joo Jung
Won-Suk Chung
Research01 Aug 2022
Nature Aging

Volume: 2, P: 726-741
Genotyping-by-sequencing reveals low genetic diversity and peripheral isolation in Southern populations of Sophora koreensis, a Korean endemic shrub

Young-Ho Ha
Jong-Bin An
Hee-Young Gil
ResearchOpen Access23 May 2025
Scientific Reports

Volume: 15, P: 1-11
Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

Jae-Hyung Jin
Kyung-Tae Lee
Yong-Sun Bahn
ResearchOpen Access24 Aug 2020
Nature Communications

Volume: 11, P: 1-17
EAAC1 gene deletion reduces adult hippocampal neurogenesis after transient cerebral ischemia

Bo Young Choi
Seok Joon Won
Sang Won Suh
ResearchOpen Access02 May 2018
Scientific Reports

Volume: 8, P: 1-12
Freezability biomarkers in bull epididymal spermatozoa

Do-Yeal Ryu
Won-Hee Song
Myung-Geol Pang
ResearchOpen Access05 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
Interference haptic stimulation and consistent quantitative tactility in transparent electrotactile screen with pressure-sensitive transistors

Electrotactile systems can have inconsistent tactile results due to variations in pressure between the device and finger. Here, the authors report a transparent electrotactile device with pressure-sensitive transistors, enabling consistent electrotactility while interference stimulation maximizes the performance.

Kyeonghee Lim
Jakyoung Lee
Jang-Ung Park
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Development of a machine learning model to identify intraventricular hemorrhage using time-series analysis in preterm infants

Hye-Ji Han
Hyunmin Ji
Young Hwa Jung
ResearchOpen Access10 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

Uninterrupted monitoring of pressure and temperature at skin interfaces can help to minimize the potential for pressure injuries in hospitalized or bedridden patients. Here, the authors introduce a soft, skin-mountable sensor that can continuously provide readings via antennas mounted under bedding, and demonstrate the functionality and robustness of the devices on patients.

Yong Suk Oh
Jae-Hwan Kim
John A. Rogers
ResearchOpen Access24 Aug 2021
Nature Communications

Volume: 12, P: 1-16
β-Sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis

Cheol Park
Dong-oh Moon
Yung hyun Choi
Research01 Mar 2008
Acta Pharmacologica Sinica

Volume: 29, P: 341-348
Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice

Hee-Young Chae
Byung-Wan Lee
Kwang-Won Kim
ResearchOpen Access01 Dec 2005
Experimental & Molecular Medicine

Volume: 37, P: 513-523
Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

Hee-Jae Cha
Moon-Taek Park
Kyu-Won Kim
Research18 Feb 1998
Oncogene

Volume: 16, P: 771-778
Hard X-ray free-electron laser with femtosecond-scale timing jitter

The Pohang Accelerator Laboratory X-ray Free Electron Laser (PAL-XFEL) in South Korea has now entered operation with a timing jitter of just 20 fs.

Heung-Sik Kang
Chang-Ki Min
In Soo Ko
Research31 Oct 2017
Nature Photonics

Volume: 11, P: 708-713
Ultrathin ferroic HfO₂–ZrO₂ superlattice gate stack for advanced transistors

In the standard Si transistor gate stack, replacing conventional dielectric HfO₂ with an ultrathin ferroelectric–antiferroelectric HfO₂–ZrO₂ heterostructure exhibiting the negative capacitance effect demonstrates ultrahigh capacitance without degradation in leakage and mobility, promising for ferroelectric integration into advanced logic technology.

Suraj S. Cheema
Nirmaan Shanker
Sayeef Salahuddin
Research06 Apr 2022
Nature

Volume: 604, P: 65-71
Lithium intercalation mechanism into FeF₃·0.5H₂O as a highly stable composite cathode material

Ghulam Ali
Ji–Hoon Lee
Kyung Yoon Chung
ResearchOpen Access07 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Electric Field-aided Selective Activation for Indium-Gallium-Zinc-Oxide Thin Film Transistors

Heesoo Lee
Ki Soo Chang
Hyun Jae Kim
ResearchOpen Access11 Oct 2016
Scientific Reports

Volume: 6, P: 1-10
High-pressure Gas Activation for Amorphous Indium-Gallium-Zinc-Oxide Thin-Film Transistors at 100 °C

Won-Gi Kim
Young Jun Tak
Hyun Jae Kim
ResearchOpen Access14 Mar 2016
Scientific Reports

Volume: 6, P: 1-7
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Author Correction: Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

Yong Suk Oh
Jae-Hwan Kim
John A. Rogers
Amendments and CorrectionsOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1
Interrelationships between Rheological, Morphological, and Mechanical Properties of Polystyrene/Liquid Crystalline Polymer Blends

Gi Dae Choi
Seung Hyun Kim
Won Ho Jo
Research01 Jun 1996
Polymer Journal

Volume: 28, P: 527-534
Life expectancy of patients with early gastric cancer who underwent curative gastrectomy: comparison with the general population

Seul Gi Oh
Ba Ool Seong
Seonok Kim
ResearchOpen Access12 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
HER2 as a potential biomarker of lymph node metastasis in undifferentiated early gastric cancer

Sanghoon Han
Sungjin Park
Jung Ho Kim
ResearchOpen Access24 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Comprehensive genomic characterization defines human glioblastoma genes and core pathways

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

Roger McLendon
Allan Friedman
Elizabeth Thomson
Research04 Sept 2008
Nature

Volume: 455, P: 1061-1068
Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer

Sera Lim
Yesol Kim
Jong Hoon Park
ResearchOpen Access11 Oct 2020
Oncogenesis

Volume: 9, P: 1-14
Prognosis of non-small-cell lung cancer in patients with idiopathic pulmonary fibrosis

SongYi Han
Yeon Joo Lee
Sang Hoon Lee
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
A Neurostimulant para-Chloroamphetamine Inhibits the Arginylation Branch of the N-end Rule Pathway

Yanxialei Jiang
Won Hoon Choi
Min Jae Lee
ResearchOpen Access12 Sept 2014
Scientific Reports

Volume: 4, P: 1-10
AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

An investigation into the nuclear events involved in autophagy regulation identifies the histone arginine methyltransferase CARM1 as a transcriptional co-activator of transcription factor TFEB; CARM1 levels are decreased by the SKP2-containing E3 ubiquitin ligase and increased during autophagy induction after nutrient starvation.

Hi-Jai R. Shin
Hyunkyung Kim
Sung Hee Baek
Research15 Jun 2016
Nature

Volume: 534, P: 553-557
Buffering of cytosolic calcium plays a neuroprotective role by preserving the autophagy-lysosome pathway during MPP⁺-induced neuronal death

Shinae Jung
Yuhyun Chung
Young J. Oh
ResearchOpen Access19 Aug 2019
Cell Death Discovery

Volume: 5, P: 1-15
Associations between genetic polymorphisms of membrane transporter genes and prognosis after chemotherapy: meta-analysis and finding from Seoul Breast Cancer Study (SEBCS)

Ji-Eun Kim
Jaesung Choi
Ji-Yeob Choi
Research04 Apr 2018
The Pharmacogenomics Journal

Volume: 18, P: 633-645
Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis

Yuhyun Chung
Juhyung Lee
Young J. Oh
ResearchOpen Access11 Dec 2018
Cell Death & Disease

Volume: 9, P: 1-19
Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model

Namgue Hong
Gi Won Kang
Jin-Chul Ahn
ResearchOpen Access09 Sept 2022
Scientific Reports

Volume: 12, P: 1-11
Continuous cropping of endangered therapeutic plants via electron beam soil-treatment and neutron tomography

Cheul Muu Sim
Bong Jae Seong
Bernd Honermeier
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-14
Material and structural considerations for high-performance electrodes for wearable skin devices

A key aspect of wearable devices used in personal health monitoring are the electrodes that make contact with the skin. This Review discusses how the materials and structure of electrodes used in these devices are vital to their performance, including how altering these factors might optimize their function.

Kyeonghee Lim
Hunkyu Seo
Jang-Ung Park
ReviewsOpen Access11 Apr 2024
Communications Materials

Volume: 5, P: 1-17
Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

Ji-Yun Chung
Hee Ra Park
Bum-Joon Park
Research22 Apr 2013
Laboratory Investigation

Volume: 93, P: 663-676

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