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Understanding interfaces at sub-nanometer scales is vital for complex chemical reactions. Here, the authors advance Pattern-enhanced Resonant Soft X-ray Scattering, enabling efficient operando probing of chemical and structural dynamics at solid-liquid interfaces.

As an important class of open-shell molecules characterized by triangular nanographenic structures and interesting magnetic properties with high-spin ground states, triangulenes are attractive targets. Here, the authors report a highly stable aza-derivative of [4]triangulene triradical with a quartet ground state.

The authors present evidence for the coexistence and coupling of ferroelectricity and superconductivity at amorphous LaAlO3/KTaO3(111) interfaces. Furthermore, flipping ferroelectric polarization reduces interfacial conductivity by more than 1000 times, and simultaneously suppresses superconductivity

The authors introduce a deep learning pipeline integrating classification, ranking, and regression modules, in which each module is trained via a few-shot learning strategy involving pretraining and multiple fine-tuning steps, to identify potent AMPs against Acinetobacter baumannii.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

Conventional carbon synthesis is energy intensive. Here, the authors introduce an energy-autonomous pathway using polyaniline-HClO₄ composites. This rapid reaction yields carbon nanosheets with tunable active sites for electrocatalysis.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

A population genomic analysis of 1,854 Listeria soil isolates collected across the contiguous United States identifies geographically prevalent phylogroups with increased pangenome openness and recombination, as a result of adaptation to variable environments.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The authors study a topological insulator (TI) sandwiched between two magnetic TIs. By keeping one of the magnetic TIs insulating, while tuning the other one into a metallic regime, they find half quantized anomalous Hall conductance, a boundary signature consistent with a quantized axion field.

Spin transport properties of magnetically ordered materials have been well studied. Here, the authors report an anomalous spin signal exhibiting spin transport over 480 microns in the frustrated hyperkagome magnetic insulator Gd₃Ga₅O₁₂.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

In this work, Wu et al. develop and present PolyCLOVER, a framework that integrates multi-stage learning, active learning, and high-throughput experimentation to iteratively discover potent, low-toxicity polymeric antibiotics without relying on external labelled data.

A universal approach to construct low-resistance oxide layer by multiple tunnelling paths is proposed for efficient and durable Si-based photocathode. This approach can speed up the pace of development of practical photoelectrochemical devices.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Van der Waals materials of the MB₂T₄ family (M = transition metal or rare-earth metal, B = Bi or Sb, T = Te, Se, or S) have attracted interest for their magnetic and topological properties, but their direct synthesis into 2D form remains challenging. Here the authors report a flux-assisted, phase-controlled growth strategy to directly grow six magnetic 2D MB₂T₄ crystals.

Protein motion in crowded environments governs cellular transport and reaction rates. Here, the authors use megahertz X-ray Photon Correlation Spectroscopy to reveal anomalous diffusion of ferritin, linking hydrodynamic and direct interactions to cage-trapping at microsecond time scales.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

MnBi₂Te₄ has an appealing combination of topological bands and magnetic ordering. While chemical doping with Sb can be used to tune these properties, it typically comes with an increase in defect density. Here, Chen, Wang, Li, Duan, and coauthors demonstrate a defect engineering approach that preserves the topological and magnetic properties of Mn(Bi_1-xSb_x)₂Te₄.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

The authors present a decoherent parallel direct laser writing (Dc-PDLW) strategy that combines a patterned single pulse with a de-coherent hologram algorithm to achieve 300 nm (~λ/4) resolution in crystal, enabling centimeter-scale 3D phase plates and dense 3D phase coding.

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

There is a lack of effective therapies for patients with non-V600E BRAF mutant cancer. Here, the authors report limited response in a phase II trial investigating the combination of binimetinib (MEK inhibitor) and encorafenib (BRAF inhibitor) for the treatment of non-V600E BRAF mutant cancer and subsequently investigate resistance mechanisms and combination therapeutic strategies in patient-derived models.

Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Conventional ammonia synthesis is energy intensive. Here the authors explore the mechanism of light-driven ammonia synthesis through in situ spectroscopy and modelling, and demonstrate that certain AuRu plasmonic alloys are promising catalysts for this potentially more sustainable process.

A transverse Peierls transition can occur when transverse acoustic phonons couple with conducting p-orbital electrons. Here, the authors observe an incommensurate transverse Peierls transition and signatures of a chiral charge density wave in EuAl₄.

A protein biomarker, the NOTCH3 extracellular domain, identifies individuals with idiopathic pulmonary hypertension, correlates with disease progression, improves mortality risk prediction and provides a readily implementable, noninvasive blood test for this disease.

This study shows how interacting filament loops in vesicles drive diverse shape transformations, highlighting their role in vesicle morphogenesis and in designing adaptive artificial cells and soft materials.

Photonic time crystals (PTCs) have unveiled unusual band structures and phenomena due to temporal modulation of optical properties. Here, the authors address non-Hermitian features of PTCs within a purely Hermitian Hamiltonian description, bridging classical and quantum approaches.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Covalently tethered borane–oxyanion organocatalysts enable highly efficient ring-opening copolymerization of epoxides and cyclic anhydrides via intramolecular cooperation, achieving turnover frequencies up to 13,500 h⁻¹ and high molecular weights up to 174.0 kDa. These catalysts feature air stability, broad substrate scope, thermal stability and metal-free polyester production.

This study elucidates nanoscopic strain evolution in single-crystal Ni-rich positive electrodes, demonstrating that mechanical failure results from lattice distortions, and redefines the roles of cobalt and manganese in battery cycling stability.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

PerioGT is a self-supervised learning framework for polymer property prediction, integrating periodicity priors and additional conditions to enhance generalization under data scarcity and enable broad applicability.

Haines et al. developed an MEK–RAF molecular glue called IK-595 that blocks MAPK pathway activation in RAS-mutant and BRAF-mutant cancer cells. IK-595 exhibited high tolerability and strong antitumor effects in preclinical models across cancer types.

This study shows that animals can adapt behaviorally to warm environments by speeding up their internal clocks. Suprathreshold temperatures activate the Lim1 pathway in the fly brain, resulting in accelerated circadian clock activity and increased early morning activity.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Williams et al. report a growth arrest mechanism in residual cancer persister cells through targeted therapy-induced upregulation of type I interferon signalling, which is negatively regulated by apoptotic DNA endonuclease DFFB to allow tumour relapse.

The properties of many high-temperature superconductors are governed by holes rather than electrons. Gauquelin et al. use atomic resolution electron energy loss spectroscopy to study the effect of oxygen doping on the valence of Cu ions and local electronic structure around the oxygen atoms in YBa₂Cu₃O_6+δ.

Here the authors propose an evaporation-driven approach to print various nanomaterials on porous substrates, allowing for high-throughput roll-to-roll and spatially programmable fabrication of functional nanomaterial films.

This study presents a generative artificial intelligence approach for the high-throughput discovery of antimicrobials against multidrug-resistant bacteria.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.