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The authors develop a miniaturized Mg3Bi2-based thermoelectric cooler, achieving a high cooling power density of 5.7 W cm-2 and a cooling speed of 65 K s-1, demonstrating great promise for localized thermal management in electronics.

This study finds that during acute viral infection of the CNS, meningeal lymphatic vessels (MLVs) can transport virus from the CNS to draining cervical lymph nodes. VEGF-C-induced expansion of functional MLVs facilitated virus clearance.

Gastrointestinal stromal tumours (GISTs) are clinically heterogeneous, with varying degrees of aggressiveness. Here, the authors describe the genomic and transcriptomic landscape of 117 GISTs from 105 patients; they find four molecular subtypes as well as recurrent inactivating YLPM1 mutations in high-risk/metastatic GIST.

The power conversion efficiency of wide-bandgap pure-sulfide kesterite is low. Wang et al. propose annealing in a hydrogen-containing atmosphere and report the underlying mechanism that enables a certified efficiency of 11.4%.

The authors obtain the TiCoSb-based single-crystals with a dimension exceeding 1 cm, leading to an extraordinary enhancement in electron mobility and consequently, an average power factor of 37 W cm⁻¹ K⁻² in the Nb-doped TiCoSb single-crystal.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

Mechanical allodynia can be socially transferred. Here, authors show that a small population of mice exhibit resilience to socially transferred allodynia, an active process mediated by ventral tegmental area glutamatergic circuits.

Layered double hydroxides are promising candidates for electrocatalytic oxygen evolution reaction yet their catalytic stability needs to be further improved. Here, the authors use trimesic acid anchoring to stabilize nickel-iron layered hydroxides for water oxidation with enhanced stability.

Scorpions have maintained the primary anatomical features of their Paleozoic arthropod ancestors. Here, the authors report the genome sequence of Mesobuthus martensiiand highlight evidence of genetic and morphological evolution that represents a unique adaptation model of arthropods.

Consistent crosstalk between cancer cells and stromal cells exists in the tumour microenvironment. Yan et al. show that exosomal miR-105 derived from cancer cells confers metabolic plasticity in recipient cancer-associated fibroblasts to adapt to nutrient-replete and -deplete conditions, thereby sustaining tumour growth.

The thermoelectric material Mg₃Bi₂ is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients.

This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalamic organization.

Li-ion cathode active materials are transitioning from poly- to single-crystal structures. However, the performance of high Ni-content single-crystal cathodes remains below expectations. Here, via Al/Zr co-doping, the authors propose a strategy to mitigate structural degradation in this class of materials.

In a mouse model of progeria, an adenine base editor delivered with adeno-associated virus corrects the pathogenic mutation in LMNA, rescues vascular pathology and markedly extends the lifespan of the mice.

Editing of a rice gene that has a role in phospholipid synthesis has endowed rice plants with broad-spectrum resistance to disease, including protection from common bacterial and fungal pathogens, without decreasing the yield.

The genome of the flying spider-monkey tree fern and investigations on stem formation and secondary metabolite biosynthesis promote our understanding of fern evolution and arborescence, facilitating the protection and utilization of this endangered species.

Single-cell transcriptomic analyses of human fetal and neonatal intestinal cells reveal a subpopulation of enteroendocrine cells that produce insulin during development.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Genome sequencing of the fall webworm, a destructive pest in Europe and Asia, suggests changes in carbohydrate metabolism, gustatory receptors and silk-yielding associated with its rapid spread.

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

This analysis presents a systematic comparison of 11 sequencing-based spatial transcriptomics methods using well-characterized references, which offers insights into performance variations in spatial transcriptomic techniques.

The E. coli GTPase HflX promotes ribosomal-subunit dissociation by inducing conformational changes in central intersubunit bridges and thereby rescues stalled ribosomes under heat-shock conditions.

The authors developed a transcriptional reporter of intracellular Ca²⁺ and used it to monitor activity in Drosophila sensory and neuromodulatory neurons. They demonstrate that this tool can be used to manipulate neurons basis of their activity and report variants that can be adapted to report activity across a wide range.