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Translocation renal cell carcinoma (tRCC) is driven by MiT family gene fusions. Here, the authors demonstrate that RNA-binding features of TFE3 fusions facilitate condensate formation, promoting transcriptional hub assembly and oncogenic gene activation.

Transarterial chemoembolization (TACE) is a common clinical intervention used for unresectable liver tumors, but conventional embolic microspheres generally exhibit slack vascular stacking and suboptimal drug release. Here, Guo et al. report tumor vessel-adaptable, adhesive, and absorbable microspheres (3Asphere) for sustained TACE therapy of liver tumors.

Dextran sulfate sodium is a colitis inducer that stimulates a ROS–Src–IP6K2 signaling axis to generate 5-IP₇, which sterically inhibits PI(4,5)P₂ phosphatases to promote PI(4,5)P₂-mediated E-cadherin endocytosis and epithelial junction breakdown.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

An analysis of genomic, molecular and neuroanatomical traits across extant primates reveals early divergence in visual and olfactory systems of major primate lineages consistent with lineage-specific shifts in diel activity and dietary niche, providing support for a sensory ‘reallocation’ hypothesis.

Pentafluorosulfanyl alcohols, compounds that serve as synthetically valuable building blocks, are difficult to prepare with current methodologies. Herein, the author report a single-step, metal-free, and photo-induced hydroxypentafluorosulfanylation of styrenes or α,β-unsaturated esters/amide for the synthesis of pentafluorosulfanyl alcohols.

Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM_2.5 and black carbon pollution over a period of 5 years.

Lfy1 is a maize mutant identified 50 years ago with increased leaf number above the primary ear and later flowering time. Here, the authors reveal that a Copia LTR-retrotransposon insertion leads to enhanced expression of an AAA ATPase encoding gene to give the mutant phenotype.

Guo, Hong et al. report that TET2 condensation maintains proper DNA demethylation at specific genomic loci, which can be targeted to alter gene expression and impair leukaemia growth.

The interventional treatment of limb-threatening ischemia calls for a medical stent. Herein, a long and biodegradable stent appropriate for below-the-knee artery is developed based on a metal-polymer composite material, where a magnetic levitation is employed to achieve a homogeneous coating.

Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.

Decoding the pathogenic genes of the inherited anemia could provide us with novel regulators of pathological and physiological erythropoiesis. Here, the authors show TLR8 is expressed by erythroid cells and regulates erythropoiesis through interacting with EPO signaling.

The cryo-electron microscopy structures of γ-secretase bound to five anticancer clinical compounds reveal characteristic differences in recognition and suggest strategies for improved drug design.

This work on 90 angiosperm tree species presents a trait-based root ‘acquisition-defence-decomposition’ framework. In support, the study shows how tree root economics strategy and mycorrhizal strategy strongly correlate with root litter chemical defences that define root decomposability, with multiple potential consequences feeding back on tree nutrition.

A high-quality reference genome assembly of cauliflower C-8 (V2) and genomic analyses of 971 diverse accessions and their relatives reveal the stepwise domestication and the genetic mechanism of curd biogenesis.

The counterion-mediated positively charged channels in covalent organic framework membranes enable the fast transport of lithium ions, realizing high lithium/magnesium selectivity without compromising lithium ion flux.

Zhang et al. perform single-cell RNA and B-cell receptor sequencing to characterize the transcriptomic profiles of B-cell acute lymphoblastic leukaemia cells at diagnosis, residual and relapse stages, uncovering the hypoxia pathway as a potential target for residual leukaemia cells.

The clinical application of inhibitors targeting checkpoint kinase 1 (CHK1) is challenged by limited efficacy. Here, the authors identify that thioredoxin (Trx) system inhibition mediates sensitivity to CHK1 inhibitor via regulating the activity of ribonucleotide reductase, demonstrating the synergistic effect of CHK1 inhibitor and inhibitors targeting Trx system in lung cancer models.

The integration of colloidal nanoparticles into microdevices is essential for several advanced technologies. Here, the authors have developed a scalable method of UV-triggered surface charge modulation for the rapid surface patterning with semiconductor nanoparticles.

Preclinical characterization of the SARS-CoV-2 M^pro inhibitor RAY1216 shows improved in vivo pharmacokinetics compared with nirmatrelvir.

In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase neutralization breadth against virus variants.

Chondrocyte senescence is known to play a role in the occurrence and progression of osteoarthritis. Here, the authors demonstrate that 10-hydroxy-2-decenoic acid (10-HDA), a small molecule derived from the food nutrient royal jelly, can prevent osteoarthritis by delaying chondrocyte senescence through targeting aspartyl β-hydroxylase.

Heterodera glycines, a soybean cyst nematode, suppresses microbial plant symbiosis by secreting the HgCht2 enzyme to hydrolyse the key symbiotic signalling molecules, lipochitooligosaccharides.

This study presents a microorganism electrocatalyst for the cathode of a microbial fuel cell that allows simultaneous electricity generation and treatment of sewage.

PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dual inhibitor/degrader of Bruton’s tyrosine kinase

The new kagome metals can exhibit unconventional electron correlated states beyond recently discovered kagome superconductors AV₃Sb₅. Here, the authors report discovery of superconductivity and intrinsic nematic order in a new titanium-based kagome metal CsTi₃Bi₅ without charge density wave order.

Hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle composed of a manganese ferrite core and surface ligands binding to hepatocyte-specific transmembrane metal and anion transporters, as shown in small and large animals.

Obesity is a risk factor for diseases. Here, authors found that inhibition of cyclin-dependent kinase 6 increased de novo lipogenesis in the adipose tissues but not in the liver, which may provide a strategy to concur obesity-induced maladies.

The neurotoxicity of organophosphate compounds damages nerve system by inhibiting acetylcholinesterase (AChE) expression, but it is difficult to overcome the deactivation of AChE. Here, the authors report the design of Lewis acid sites in metal-organic frameworks as AChE mimics for effective neuroprotection.

Genome-wide association analyses across individuals of East Asian and European ancestries identify new risk loci for inflammatory bowel diseases. A polygenic risk score derived from the combined datasets shows improved prediction accuracy.

Arabidopsis blue-light photoreceptor cryptochromes interact with ADA2b and SMC5 in a blue-light-dependent manner, which enhances ADA2b–SMC5 interaction and promotes ADA2b-mediated recruitment of SMC5 to DNA double-strand breaks, leading to break repair.