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Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

Genome sequences from 112 patients with confirmed SARS-CoV-2 infection showed two clades of SARS-CoV-2 virus with similar virulence and clinical outcome, and clinical data from 326 cases suggest that T cell depletion and cytokine bursts are associated with a worse prognosis.

Piezoelectric materials are promising for biomechanical sensing, though balancing piezoelectric and mechanical properties is challenging. Here, the authors report a polymer film utilizing liquid-liquid interface, optimizing these properties for biomechanical sensors.

Glucocorticoids (GCs) inhibit bone angiogenesis and affect bone development, but the underlying mechanisms remain unclear. Here, the authors show that GCs induce vascular cell senescence during bone development by inhibiting angiogenin secretion from osteoclasts, impairing angiogenesis via endothelial Plexin B2, resulting in unpaired bone growth.

Continuous shape morphing for small robots can offer advantages, but it is difficult to perform tasks if they are not stiff enough. Xu et al. present here a design combining liquid crystal elastomers and shape memory polymers to lock morphable elements in place.

The diversity and genomic resources of Brassicaceae make it an ideal model for studying karyotype evolution. Here, the authors reconstruct ancestral karyotypes of Camelinodae and Brassicodae, identify cascading fusions, and highlight their stable inheritance and role in evolutionary relationships.

The development of n-type organic semiconductors (OSCs) has been held back due to stability issues. Here the authors report that vitamin C improves both the performance and stability of n-type OSCs and devices.

PBHL-seq provides an accessible workflow for expression profiles from the region of interest in fresh frozen and FFPE tissue at subcellular resolution, while keeping the sample intact for downstream applications.

[n]Peri-acenes have attracted interest as promising candidates for nanoelectronics and spintronics but the synthesis of large (n > 4) [n]peri-acenes is extremely challenging due to their intrinsic open-shell radical character and high reactivity. Herein, the authors report the synthesis and isolation of a derivative of peri-hexacene in crystalline form.

This research identifies a regulatory role for the receptor-like kinase FERONIA in Arabidopsis roots, finding that it balances growth and immunity by activating localized immunity in response to bacterial colonization.

Oil reservoirs host diverse microbial communities affecting energy production and carbon emissions. Here, the authors use metagenomics data to construct and characterize a catalogue of viral and prokaryotic genomes from 182 oil reservoirs world-wide, and further validate an ecological role of viruses in regulating the community structure of sulfate reducing microorganisms.

Enveloped viruses encased within a lipid bilayer membrane are highly contagious and cause diseases like influenza and COVID-19, so strategies for their prevention and inactivation are needed. Here, the authors develop a diatomic iron nanozyme with lipoxidase-like activity for the inactivation of enveloped viruses, where the diatomic iron sites destroy the viral envelope via lipid peroxidation.

Tree height and forest structure may both determine forest responses to drought. Here, the authors analyse highresolution airborne LIDAR data on <1 million trees during the 2012-2016 California drought and find that presence of both tall trees and structurally complex stands reduces tree mortality under drought.

Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IFN-γ with IDO1 inhibitors results in enhanced tumour regression.

Invasive early stage lung adenocarcinoma has a heterogeneous prognosis. Here, the authors microdissect malignant pulmonary nodules to invasive and preinvasive components and study the mutations that are common or private between the lesions, allowing them to understand the evolutionary path of the tumours.

Graphene holds great potential for use in photodetectors, owing to its ability to absorb light over a wide range of wavelengths. Here Zhang et al. report a large photoresponsivity of 8.6 AW-1 over a broad wavelength range in pure monolayer graphene.

Vascularization is critical for cranial bone growth, maintenance, and healing, but it remains unknown how blood vessels are spatially distributed in the calvarium, and how they interact with skeletal progenitors during these processes. Here, the authors apply a quantitative light-sheet imaging platform to visualize and analyze the relationship between blood vessels and skeletal progenitors throughout the murine calvarium.

Coupling graphene with narrow band-gap Ti₂O₃ nanoparticles can enable efficient mid-infrared photodetection. Here, the authors report a graphene-Ti₂O₃ based hybrid photodetector with high responsivity of ~300 A W^-1 up to 10 μm by varying the number of graphene layers and size of Ti₂O₃ nanoparticles.

Crystal facet orientations of the polycrystalline hybrid lead halide perovskite thin films play a crucial role in determining the device performance. Here Zheng et al. demonstrate effective control of the crystal stacking mode by cation cascade doping, which promotes the charge transport in the photovoltaic device.

Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.

Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by preventing AR interaction with HSP90, results in ubiquitin/proteasome-mediated degradation of the receptor.

The theoretical unlimited orbital angular momentum states have been utilized as node signals in an optical neural network to implement machine learning tasks.

KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis

SenNet Consortium members review current and emerging methodologies for spatially resolved mapping of senescent cells. They discuss their limitations and challenges involved in the aim of creating a comprehensive atlas of senescent cells during aging.