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Migration patterns of the wheat stripe rust pathogen from oversummering regions to adjacent areas were identified, revealing two dispersal routes of disease spread and providing insights for regional and national disease management strategies.

Resequencing of 390 peanut accessions provides insights into peanut migration and diversity in China. Genome-wide association analysis identifies loci associated with 28 agronomic traits.

Combined addition of macroalgae and nitrogen enhanced decomposition of recalcitrant organic matter in sheath, whereas it was meditated by litter quality and microbes, according to laboratory experiments spanning 116 days with two seagrass litters.

Here, the authors apply the Activity-by-Contact (ABC) model to infer enhancer-gene regulation and the effect of associated variants across multiple cancer types, integrating genetic and multi-omics data. Then, they explore the mechanisms associated with ABC regulatory variants in colorectal cancer.

Pericytes play an essential role in blood brain barrier (BBB) integrity. Here, the authors generate pericyte-like cells (PCs) from human pluripotent stem cells (hPSCs) which display functional properties and also promote BBB recovery in a mouse model of cerebral artery occlusion.

The evolutionary trajectory of avian sex chromosomes may be more intricate than previously understood. In this study, sequencing and analysis of the neo-sex chromosomes and genome of the Crested Ibis suggests a multidirectional evolution of sex chromosomes in core waterbirds.

Whole-genome sequences of wild rice and cultivated rice varieties are used to produce a map of rice genome variation, and show that rice was probably first domesticated in southern China.

A thin elastic conductive nanocomposite that is formed by cryogenically transferring laser-induced graphene to a hydrogel film can be used to create multifunctional sensors for on-skin monitoring and cardiac patches for in vivo detection.

CO₂ hydrogenation has attracted intense scientific attention yet suffers from the disadvantage of poor activity and low selectivity. Here, the authors report that Cu single atom catalysts with tailored coordination environments on C₃N₄ serve as highly selective catalysts for CO₂ hydrogenation.

Cells contain isolated compartments that spatially confine different enzymes, enabling high-efficiency enzymatic cascade reactions. Herein, the authors report a cell-inspired design of biomimetic cascade catalysis system by immobilizing Fe single atoms and Au nanoparticles on the inner and outer layers of three-dimensional nanocapsules, respectively, to enable highly selective colorimetric glucose detection.

Conventional material processing methods often suffer by strength-ductility trade-off. Here, the authors show high-pressure and high-temperature treatment can transform an eutectic high entropy alloy to having a hierarchical microstructure with simultaneous enhancements of strength and ductility.

Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.

In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase neutralization breadth against virus variants.

One-dimensional atomic metal wires can exhibit useful properties distinct from their bulk equivalents; however they typically suffer from limited stability. Here, Chen et al create atomic silver wires which are stable and exhibit a temperature dependent metal to insulator transition.

Here the authors pull apart the cellular composition of the tumor microenvironment using RNA sequencing data from a wide variety of cancer types. They identify immunity quantitative trait loci and integrate these data with analysis of colorectal cancer cohorts, creating a polygenic risk score and a database for community access.

Genome-wide association analyses across individuals of East Asian and European ancestries identify new risk loci for inflammatory bowel diseases. A polygenic risk score derived from the combined datasets shows improved prediction accuracy.

Chiral receptors with an endo-functionalized cavity for chiral recognition are of interest in the field of molecular recognition. Here, the authors develop chiral naphthotubes containing a bis-thiourea endo-functionalized cavity to effectively recognize neutral chiral molecules with high enantioselectivity.

Cao and colleagues found that the microRNA miR-1 promotes IFN-γ-mediated clearance of Listeria monocytogenes in macrophages by stabilizing the Stat1 mRNA through the degradation of the cytoplasmic long noncoding RNA Sros1.

Shared socioeconomic pathways (SSPs) is a crucial scenario describing the potential of future socio-economic development. The authors here investigate long-term effects of various government policies suggested by different SSPs on urban land and reveal the impact of future urban expansion on other land and food production.

Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

The RNA-binding proteins Lin28A and Lin28B are known to have key roles in a variety of pathological states including cancer, obesity and diabetes. Here the authors show that Lin28A and -B alter cancer metabolism through let-7-mediated upregulation of pyruvate dehydrogenase kinase 1.

Single-cell RNA-sequencing of seven mouse developmental stages identifies lineage-specific and shared regulatory programs controlling cell-fate decisions. Cross-species analysis associates differentiation potency with ribosomal protein gene expression.

Inspired by the processes of thrombus formation and thrombolysis in blood vessels, the authors here construct an electrochemically recoverable protective layer of polysulfides using an electrolyte additive, realizing high performance Li–S batteries.

The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform a metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls, identifying microbial strains and functions associated with the disease.

Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.

The Mexican axolotl is a well-established tetrapod model for regeneration and development. Here the authors report a scRNA-seq method to profile neotenic, metamorphic and limb development stages, highlighting unique perturbation patterns of cell type-related gene expression throughout metamorphosis.

Dongxin Lin, Chen Wu and colleagues identify a LINC00673 variant that associates with pancreatic cancer risk in Han Chinese cohorts. They show that the variant creates a target site for miR-1231 and that LINC00673 regulates PTPN11 degradation and leads to altered SRC–ERK and STAT1-dependent signaling.