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Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

Hanshen Yang
Xiaozhen Zhang
Xueli Bai
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Correction: Effect of natural environmental changes on Hainan migratory population with hypertension in China and related plasma metabolism features

Sha Xiao
Shuyue Liu
Ping Xue
Amendments and CorrectionsOpen Access15 Oct 2025
Scientific Reports

Volume: 15, P: 1-4
Self-assembled hole-selective contact for efficient Sn-Pb perovskite solar cells and all-perovskite tandems

The development of hole-selective contacts for Sn-based perovskite solar cells is highly desirable. Here, the authors report self-assembled monolayers with oligoether side chains on the benzothiadiazole unit and achieve an efficiency of 28.61% for operationally stable all-perovskite tandems.

Jingwei Zhu
Xiaozhen Huang
Dewei Zhao
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Lacticaseibacillus rhamnosus GR-1 prevents autism-like behaviors by reshaping the maternal and offspring microbiome

Ruili Yang
Yi Xu
Hui-Li Wang
ResearchOpen Access24 Sept 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-17
Gene drive-based population suppression in the malaria vector Anopheles stephensi

Gene drive alleles bias their inheritance to spread through populations. Here, we constructed a moderate efficiency 2-gRNA nanos-Cas9 homing suppression drive in the malaria mosquito Anopheles stephensi targeting doublesex. With vasa-Cas9, high efficiency and self-limiting suppression was achieved.

Xuejiao Xu
Jingheng Chen
Jackson Champer
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-10
ROS regulated reversible protein phase separation synchronizes plant flowering

Plants utilize naturally produced ROS in shoot apical stem cells as a developmental signal to trigger phase separation of TMF. The resulting transcriptional condensates repress expression of the floral identity gene to precisely time flowering.

Xiaozhen Huang
Shudong Chen
Cao Xu
Research25 Feb 2021
Nature Chemical Biology

Volume: 17, P: 549-557
Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

Wenying Yang
Dalong Zhu
Li Chen
ResearchOpen Access12 May 2022
Nature Medicine

Volume: 28, P: 974-981
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK

Adipose tissue macrophage (ATM) has been implicated in inflammation and obesity, but the underlying mechanisms are still unclear. Here the authors show that AMPK is suppressed in ATMs from mice fed with high fat diet, leading to subsequent activation of SUCLA2, over-production of succinate and IL-1β, and ultimately inflammation and obesity.

Chang Peng
Haowen Jiang
Jia Li
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Effect of natural environmental changes on Hainan migratory population with hypertension in China and related plasma metabolism features

Sha Xiao
Shuyue Liu
Ping Xue
ResearchOpen Access30 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
In vivo genome editing via CRISPR/Cas9-mediated homology-independent targeted integration for Bietti crystalline corneoretinal dystrophy treatment

Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive chorioretinal degenerative disease without approved therapeutic drug. Here, the authors show a promising CRISPR/Cas9 mediated homology-independent targeted integration therapy in patient derived cells and humanized mice carrying BCD mutations.

Xiang Meng
Ruixuan Jia
Liping Yang
ResearchOpen Access06 May 2024
Nature Communications

Volume: 15, P: 1-18
Physical activity moderates the mediating role of depression between experiential avoidance and Internet addiction

Jiale Wang
Li Tang
Shiju Zhu
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

Multi-omics data are readily integrated using quartet reference materials.

Yuanting Zheng
Yaqing Liu
Leming Shi
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 1133-1149
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer

Song and colleagues report that in breast cancer, chemotherapy induces the IRENA lncRNA, which reprograms tumor suppressive macrophages to protumorigenic phenotypes and promotes chemoresistance.

Jiang Liu
Liyan Lao
Erwei Song
Research12 Apr 2021
Nature Cancer

Volume: 2, P: 457-473
Increased CO₂ fixation enables high carbon-yield production of 3-hydroxypropionic acid in yeast

CO₂ fixation plays an important role to make bioproduction cost competitive. Here, the authors take 3-hydroxypropionic acid as an example to showcase how to achieve high carbon yield production through increasing the accessible bicarbonate, minimizing native CO₂ release and avoiding carbon waste.

Ning Qin
Lingyun Li
Zihe Liu
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-15
A secreted effector with a dual role as a toxin and as a transcriptional factor

Bacteria can deliver toxic effector proteins into the cytosol of neighboring cells. Here, the authors show that Yersinia pseudotuberculosis secretes an effector that modulates gene expression in neighboring cells of the same species and inhibits the growth of other competitors.

Dandan Wang
Lingfang Zhu
Xihui Shen
ResearchOpen Access16 Dec 2022
Nature Communications

Volume: 13, P: 1-15
MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake

The microRNA miR-21 is induced in the islets of patients with glucose intolerance and diabetic mice. Here the authors report that deletion of miR-21 in pancreatic β-cells impairs glucose-stimulated insulin secretion via reduced glucose uptake, while a miR-21 agomir reduces blood glucose leves in diabetic male mice.

Ruiling Liu
Cuilian Liu
Qingguo Ruan
ResearchOpen Access21 Jun 2022
Nature Communications

Volume: 13, P: 1-15
All-passive microwave-diode nonreciprocal metasurface

The conventional methods to break reciprocity in the microwaves involve bulky magnets and complex spatial-temporal modulation, impairing the development in modern compact electronic systems. To circumvent this problem, the authors realize a lightweight, integrable, and all-passive metasurface that enables nonreciprocal transmission.

Xiaozhen Yang
Erda Wen
Daniel Sievenpiper
ResearchOpen Access21 Nov 2023
Communications Physics

Volume: 6, P: 1-6
Benefits of organic manure combined with biochar amendments to cotton root growth and yield under continuous cropping systems in Xinjiang, China

Zhiyong Zhang
Xiuxiu Dong
Xiaozhen Pu
ResearchOpen Access13 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Real-data-driven real-time reconfigurable microwave reflective surface

The authors demonstrate how flexible metasurfaces powered by artificial neural network can dynamically manipulate the EM scattering behavior from an arbitrary surface - an ultimate ambition for many EM stealth and communication problems.

Erda Wen
Xiaozhen Yang
Daniel F. Sievenpiper
ResearchOpen Access25 Nov 2023
Nature Communications

Volume: 14, P: 1-8
Tom70 protects against diabetic cardiomyopathy through its antioxidant and antiapoptotic properties

Peijian Wang
Dan Wang
Yongjian Yang
Research28 Jul 2020
Hypertension Research

Volume: 43, P: 1047-1056
Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes

The small molecule AI-2 acts as a quorum sensing signal, mediating communication within and between many bacterial species. Here, the authors identify a new type of AI-2 receptor, consisting of a dCACHE domain that is present in many bacterial and archaeal proteins.

Lei Zhang
Shuyu Li
Xihui Shen
ResearchOpen Access23 Oct 2020
Nature Communications

Volume: 11, P: 1-13
Intestinal MYC modulates obesity-related metabolic dysfunction

Inhibition of intestinal MYC is shown to have beneficial metabolic effects by promoting GLP-1 secretion and reducing ceramide production.

Yuhong Luo
Shoumei Yang
Frank J. Gonzalez
Research01 Jul 2021
Nature Metabolism

Volume: 3, P: 923-939
Role of polymorphic bile salt export pump (BSEP, ABCB11) transporters in anti-tuberculosis drug-induced liver injury in a Chinese cohort

Ru Chen
Jing Wang
Siyan Zhan
ResearchOpen Access13 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment

Minyuan Cao
Yun Deng
Heng Xu
ResearchOpen Access02 May 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-20
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

Mitochondria must be juxtaposed to phagosomes to supply reactive oxygen species for effective killing of microbes. Zhou and colleagues demonstrate that the kinases Mst1 and Mst2 are important for controlling this redistribution of mitochondria.

Jing Geng
Xiufeng Sun
Dawang Zhou
Research28 Sept 2015
Nature Immunology

Volume: 16, P: 1142-1152
A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study

Jing Li
Jun Xu
Jing He
ResearchOpen Access07 Feb 2025
Scientific Data

Volume: 12, P: 1-7
An investigation into the effects of soil and fastener-freezing on ground vibrations induced by high-speed train in frozen regions

Yuhao Peng
Qionglin Li
Xiaozhen Sheng
ResearchOpen Access20 Jul 2022
Scientific Reports

Volume: 12, P: 1-20
Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix

Yi Duan
Xiaozhen Zhang
Xueli Bai
ResearchOpen Access08 May 2023
Oncogene

Volume: 42, P: 2061-2073
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer

Hanshen Yang
Xiaozhen Zhang
Xueli Bai
ResearchOpen Access20 Dec 2022
Cell Death & Differentiation

Volume: 30, P: 560-575
Assessing the impact of the 2018 Changchun Changsheng vaccine incident on childhood vaccination in China

Hou, Lai et al. estimate the impact of reports regarding a childhood vaccine with compromised efficacy on subsequent vaccination behaviors. The administration of the reported vaccine was delayed, while there was minimal effect on other vaccinations.

Zhiyuan Hou
Xiaozhen Lai
Hai Fang
ResearchOpen Access22 Aug 2023
Communications Medicine

Volume: 3, P: 1-10
Integrated metabolome and transcriptome analysis provides clues to fruit color formation of yellow, orange, and red bell pepper

Qiqin Xue
Qingxia Zhang
Xiurong Zhang
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-17
Exogenous application of Eucommia ulmoides β-1, 4-glucanase promotes propagation by increasing the expression of wound healing genes

Jinyu Yang
Runying Wang
Yichen Zhao
ResearchOpen Access05 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer

Ji Zhou
Haoying Li
Tianyao Guo
ResearchOpen Access22 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells

Mengyi Lao
Xiaozhen Zhang
Tingbo Liang
ResearchOpen Access06 Apr 2021
Oncogene

Volume: 40, P: 3136-3151
The roles of arbuscular mycorrhizal fungi (AMF) in phytoremediation and tree-herb interactions in Pb contaminated soil

Yurong Yang
Yan Liang
Ming Tang
ResearchOpen Access04 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
All-trans retinoic acid enhances the cytotoxic effect of decitabine on myelodysplastic syndromes and acute myeloid leukaemia by activating the RARα-Nrf2 complex

Lu Wang
Qi Zhang
Hongyan Tong
ResearchOpen Access08 Dec 2022
British Journal of Cancer

Volume: 128, P: 691-701
The m⁶A methyltransferase METTL14 promotes cell proliferation via SETBP1-mediated activation of PI3K-AKT signaling pathway in myelodysplastic neoplasms

Lingxu Jiang
Yudi Zhang
Hongyan Tong
ResearchOpen Access25 Jul 2024
Leukemia

Volume: 38, P: 2246-2258
Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells

Guokai Yan
Retno Lestari
Xianghua Yan
ResearchOpen Access17 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Author Correction: Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1

Yue Yang
Bin Liu
Shuo Wang
Amendments and CorrectionsOpen Access16 Apr 2020
Scientific Reports

Volume: 10, P: 1
Erratum: A novel chloroplast-localized protein EMB1303 is required for chloroplast development in Arabidopsis

Xiaozhen Huang
Xiaoyan Zhang
Shuhua Yang
Amendments and Corrections01 Oct 2009
Cell Research

Volume: 19, P: 1225
Snow flea antifreeze peptide for cryopreservation of lactic acid bacteria

Xu Chen
Jinhong Wu
Vincent Guyonnet
ResearchOpen Access03 Feb 2022
npj Science of Food

Volume: 6, P: 1-10
Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial

Xiaoying Zhang
Miao Miao
Zhanguo Li
ResearchOpen Access07 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-8
Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1

Yue Yang
Bin Liu
Shuo Wang
ResearchOpen Access09 Feb 2015
Scientific Reports

Volume: 5, P: 1-9
Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages

Qi Chen
Jianxin Wang
Xueli Bai
ResearchOpen Access07 Oct 2019
British Journal of Cancer

Volume: 121, P: 786-795
Local melatonin application induces cold tolerance in distant organs of Citrullus lanatus L. via long distance transport

Hao Li
Jingjing Chang
Xian Zhang
ResearchOpen Access19 Jan 2017
Scientific Reports

Volume: 7, P: 1-15
Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis

Mengting Huang
Xin Zeng
Yong Xu
ReviewsOpen Access09 Oct 2024
Nutrition & Diabetes

Volume: 14, P: 1-12
A novel chloroplast-localized protein EMB1303 is required for chloroplast development in Arabidopsis

Xiaozhen Huang
Xiaoyan Zhang
Shuhua Yang
Research07 Jul 2009
Cell Research

Volume: 19, P: 1205-1216

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