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Designing efficient redox mediators for solar-to-fuel conversion is a challenge, requiring multi-electron transfer, suitable redox potential, and stable pH buffering. Here, the authors report polyoxometalate-based mediators with defect engineering, enabling reliable solar-to-fuel conversion.

Hydrogen production coupled with electrochemical oxidation of organic nucleophiles is often limited by catalyst’s reconstruction at the anode. Here, the authors developed the stable Ni(II) active sites in Prussian Blue analogue for fast, selective ethylene glycol electrooxidation and constructed an effective coupled electrochemical hydrogen production flow cell.

This study reveals a regulation mechanism of the ALR1 aluminium receptor involving phosphorylation switching by PP2C phosphatases and PBL27 kinase. This mechanism modulates ALR1–BAK1 complex formation, thereby controlling plant aluminium sensing and resistance.

Platelet-activating factor (PAF) and PAF-like phospholipids were identified as propagators of ferroptosis, whereas PAFAH2 suppressed synchronized ferroptosis and, thus, prevented tubular cell death in acute kidney injury.

Reconfigurable nonlinear Pancharatnam-Berry liquid crystals have been proposed, serving as a design framework for developing multifunctional dynamic nonlinear optics devices.

Photoacoustic imaging has generated increasing interest for uses in preclinical research and clinical translation. Here the authors develop a three-dimensional photoacoustic computed tomography system that allows for multipurpose imaging of biological tissues ranging from the rodent brain to the human breast.

Artificial photosynthetic diluted CO₂ reduction from fuel gas is promising but challenging for carbon neutrality. Here, the authors report a host-guest system by integrating CO₂-enriching ionic liquids and photoactive metal-organic frameworks, greatly enhancing CO₂-to-CO conversion efficiency.

Bronchopulmonary dysplasia and chronic obstructive pulmonary disease are marked by neutrophilic inflammation and microbial changes. Here, the authors show the efficacy of an inhaled live biotherapeutic in reducing inflammation and improving tissue structure across models of respiratory disease.

The electrosynthesis of multicarbon products from CO₂ is a highly attractive way to utilize emitted CO₂. Here, the authors report in situ formed Cu⁰/Cu²⁺ interfaces from copper phosphate-based electrocatalysts for promoting selectivity toward multicarbon products through OC-CHO coupling.

Hydroxycarboxylic acid receptor 2 (HCAR2) has been implicated in cardiovascular and neuroinflammatory diseases. Here, the authors present cryo-EM structures of HCAR2-Gi1 complexes bound to different ligands and provide insights into the mechanisms of both orthosteric and allosteric modulation of HCAR2.

The cryo-electron microscopy structure of the GPR101–Gs complex reveals the mechanism for its constitutive activity and facilitates the screening and identification of GPR101 ligands with rejuvenating potential.

The authors provide a comprehensive characterization of the human antibody response to a licensed hepatitis E virus (HEV) vaccine, Hecolin, in four individuals over the course of six months post vaccination. They demonstrate diverse patterns of antibody response underlying the vaccine protection.

A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

MRGPRX1 is a key GPCR expressed in the DRG for itch perception, generating scratch or avoidance behaviors. Here, authors provide structural and pharmacological insights into itch sensation, activation and G-protein signaling downstream of MRGPRX1.

α1-adrenergic receptors (α1- AR) play critical roles in the cardiovascular and nervous systems. Here, the authors report molecular insights into the mechanisms underlying the discrimination between α1A-AR and α1B-AR by the agonist A61603.

Cryo-electron microscopy structures of three adhesion G protein-coupled receptors (aGPCRs) complexes provide insight into the tethered activation mechanism of aGPCRs and show the potential for rational design of agonists.

This study demonstrates that DCUN1D5 influences the immune microenvironment of osteosarcoma, resulting in enhanced tumor growth, immune evasion, and resistance to cisplatin, which ultimately leads to poorer patient outcomes.

Zhou et al. developed a specific small-molecule inhibitor of astrocytic Kir4.1 channels, Lys05, which exerts rapid-onset antidepressant effects in rodents without unwanted side effects, indicating Kir4.1 as a promising drug target.

Commercial complementary metal–oxide–semiconductor and resistive random-access memory technologies can be used to create multibit compute-in-memory circuits capable of fast and energy-efficient inference for use in small artificial intelligence edge devices.

The description of the cryo-EM structure of an orphan adhesion GPCR–G_s protein complex in apo state facilitates the screening and identification of potential ligands of ADGRG2.

Notch signaling activation drives an endothelial-to-mesenchymal transition critical for heart development. Here, the authors investigate the role of NOTCH1 intracellular domain (NICD1) in the mitochondria of developing mouse fetal hearts.

This study demonstrates a WAKL4 receptor-like kinase that is rapidly and specifically induced by Cadmium. It reveals a unique mechanism conferred by the WAKL4-NRAMP1 module that enables plants to actively respond to Cadmium and limit its uptake.

This study reveals how Klotho and heparan sulfate glycosaminoglycan coreceptors enable FGF hormones to induce asymmetric 1:2 FGF–FGFR dimerization mandatory for FGFR kinase activation and hence signalling.

N⁶-methyladenosine (m⁶A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m⁶A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m⁶A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.

Stimulated Raman scattering (SRS) microscopy enables label-free chemical imaging at high speed, but has been limited by low sensitivity. Here, the authors demonstrate plasmon-enhanced SRS microscopy and achieve single molecule detection sensitivity.

The interventional treatment of limb-threatening ischemia calls for a medical stent. Herein, a long and biodegradable stent appropriate for below-the-knee artery is developed based on a metal-polymer composite material, where a magnetic levitation is employed to achieve a homogeneous coating.

When near-infrared femtosecond laser pulses are focused onto a metal wire, relativistic electron acceleration is observed in the attached waveguide. An electron energy gain of 1.1 MeV and an effective acceleration gradient up to 210 MV m⁻¹ are achieved using the laser-induced terahertz surface waves.

Although methodologies to modify the cores of numerous heterocycles have recently been investigation, studies of deconstructive ring-openings of the pharmaceutically important pyrazole structure are scarce. Here, the authors present a methodology using iodine and heat to reformat substituted pyrazoles into fused tricyclic azaheterocyclic (pyrazolopyridopyridazin-6-one) scaffolds.

Solid-state thermoelectrics can convert waste heat to electrical energy, but applications are hindered by long-term stability issues. Here cobalt is used as a contact layer with direct bonding to thermoelectric MgAgSb, enabling a thermoelectric module to achieve 10.2% conversion efficiency over 1,440 h of thermal cycling.

Analysis of tumor samples from patients with nasopharyngeal carcinoma shows that gemcitabine plus cisplatin chemotherapy activates a unique population of innate-like B cells, which enhance the cytotoxic CD8⁺ T cell response and are associated with better clinical outcomes.

By applying operant conditioning, behavioral manipulation, in vivo electrophysiology, computational modeling, and closed-loop optogenetics, the authors reveal a mechanism for action timing in mice mediated by the secondary auditory cortex.

Cell-type-specific recording and manipulation is important for understanding neural circuits. Here the authors describe molecular tools to access cell types based on genetics and connectivity in the brain, and demonstrated the utility of these tools in neural recording and manipulations.

Inositol hexaphosphates (InsP6) are ubiquitous in eukaryotes and regulates a plethora of cellular functions. Here the authors identify a set of receptor-like cytoplasmic kinases that work in concert with 14-3-3- proteins to regulate InsP6 synthesis and accumulation and Pi homeostasis in Arabidopsis.

Pancreatic ductal adenocarcinoma (PDAC) cells can utilise the tumour microenvironment to metastasise to the liver. Here the authors show that hepatoctyes overexpress SLIT2 to enable premetastatic niche formation for ROBO1-positive PDAC cells to support the survival of these tumour cells in the liver.

The authors report on the structure of a glucocorticoid-bound adhesion G-protein-coupled receptor–G protein complex.

The human gonadotropin-releasing hormone receptor GnRH1R is a GPCR with an important role in the human reproductive system and of interest as a drug target. Here, the authors present the 2.8 Å crystal structure of human GnRH1R with the high affinity antagonist drug Elagolix and the observed unusual ligand binding mode was further analysed with functional assays and molecular docking studies.

Using cryo-electron microscopy, the authors report the structures of G-protein-coupled bile acid receptor–G_s complexes and reveal the structural basis of bile acid recognition.

The cryo-EM structure of a megacomplex between chimeric GPCR, G protein and β-arrestin in their canonical active conformations provides insight into the basis of sustained G protein signaling upon megacomplex internalization.

The stress etiology of depression remains elusive. Here, authors show that dynorphin/KOR signaling-mediated impairment of excitatory synaptic transmission from claustrum to prelimbic cortex PV interneurons contributes to stress-induced depression.

Chen et al. provide an m⁵C landscape in bladder cancer and show m⁵C enrichment at oncogene mRNAs that promotes tumour progression. They identify YBX1 as the m⁵C ‘reader’ that recruits ELAVL1 to stabilize mRNAs.