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Glioblastoma stem cells (GSCs) contribute to tumor recurrence and resistance to therapy. Here, the authors show that ICAM1 enhances GSC stemness and promotes immune evasion through the β-catenin/PD-L1 signaling pathway.

Mycobacterium tuberculosis produces linoleic acid, which is released from macrophages during infection and upregulates regulatory T cell activity, to suppress macrophage control of intracellular bacteria in mice.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Prostate cancers (PCa) are characterized by an immunosuppressive tumor microenvironment. Here the authors identify a subset of iron-loaded cancer-associated fibroblasts secreting myeloid cell-associated proteins and driving immunosuppression in PCa.

The insertion of thin layers of cobalt can stabilize β-tungsten under back-end-of-line thermal constraints, allowing a 64-kb spin–orbit torque magnetic random-access memory to be fabricated that offers a spin–orbit torque switching of 1 ns, data retention of more than 10 years and a tunnelling magnetoresistance of 146%.

Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.

This study introduces Uni-C, a single-cell method to map chromatin structure and genomic alterations in circulating tumor cells, enabling detection of genomic variants and neoantigen prediction to advance early diagnosis and therapeutic strategies.

Zhu and colleagues show that a subpopulation of spleen-derived fibroblasts secrete Gremlin 1, which suppresses chronic myeloid leukemia progression by inducing leukemia stem cell apoptosis through the BMP signaling pathway.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Influenza A virus neuraminidase (NA) is an important target for universal influenza vaccines. Here, the authors identify two monoclonal antibodies, CAV-F6 and CAV-F34, that inhibit NA activity across multiple subtypes, offering protection against seasonal and emerging avian influenza strains, thus advancing the development of broadly protective vaccines and therapeutics.

Stress shielding, a common cause of orthopedic implant failure, reduces the activity of intracellular mechanotransduction molecules, which are also regulated by nociceptors. Here, Wang et al. develop a small, implantable, wirelessly rechargeable device for optogenetic regulation of mechanosensitive nociceptors to investigate and improve implant osseointegration.

The commercialization of organic solar cells has been hindered by the limited device stability. Here, authors show that the connectivity of electron transport network is a key factor determining electron transport and device stability, with polymeric acceptors likely to establish such a network.

Single-molecular microscopy shows that GAGA multimeric zinc finger transcription factor searches chromatin for cognate sites through rapid one-dimensional sliding on free DNA (which can be blocked by nucleosomes) and three-dimensional diffusion for nucleosomal targets.

Focal cortical dysplasia type II causes epileptic seizures and is associated with various types of neuronal abnormalities. This study uses patient tissue transcriptomics and animal models to reveal that vascular malformations are a key part of the pathology by creating ischemic-hypoxic microenvironments.

In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

One challenge for spin-based electronics is the controlled and reliable switching of magnetization without magnetic fields. Here, Liu et al investigate a variety of compositions of CoPt, and determine the specific composition to maximize switching performance, potentially simplifying device design.

Meta-learning-empowered reflective lattice light-sheet virtual structured illumination microscopy (Meta-rLLS-VSIM) offers near-isotropic resolution for fast and versatile super-resolution imaging of subcellular dynamics

Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome engineering.

Marginal liver grafts are associated with a higher risk of graft failure due to their increased susceptibility to ischemia-reperfusion injury. Here, the authors show the regulatory mechanism of fibroblast growth factor 21 and offer insights into its clinical application in early liver graft injury.

Deterministic generation of a continuous-variable eight-mode entanglement on an integrated optical chip is reported.

Zhang et al. report that the systemic mitochondrial unfolded protein response triggered by neuronal mitochondrial stress can be transmitted across multiple generations in Caenorhabditis elegans via a mechanism involving elevation in mitochondrial DNA levels in oocytes.

Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. Here, the authors show that SGK1 drives hippocampal demyelination and DACD via regulating NDRG1 phosphorylation.

Tuning interspecies interactions in atomic Bose–Fermi mixtures is shown to drive the system through a quantum phase transition. This enables the generation of heteronuclear molecules in the quantum-degenerate regime.

The high trap density associated with tin (II) oxidation impacts the device performance of methylammonium cation-free tin-lead perovskite solar cells. Here, authors employ rubidium acetate for defect passivation and achieve efficient and stable single-junction and all-perovskite tandem solar cells.

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

Molecular triplet-triplet upconversion is useful in a wide range of applications, but is limited by significant oxygen quenching. Here the authors report the combination of sensitiser and annihilator that is stable in aerated environments, and suitable for in vivo sensing.

Manual injection, which remains low-throughput and labor-intensive, is a technical bottleneck for large-scale genetic studies of C. elegans. Here, the authors report a robotic microinjection system which facilitates injection speed while maintaining injection quality which is comparable to experienced experts.

Achieving direct solar-to-hydrogen conversion from pure water using solely organic heterogeneous catalysts is still challenging. Here the authors report an all-organic semiconductor catalyst system for overall water splitting under visible to near-infrared light via triplet-triplet annihilation up conversion based on spin coupling.

Chemical probes that selectively react with histidine could afford functional insight for those located in vital protein regions, but the moderate nucleophilicity of histidine and interference from other residues pose challenges. A singlet oxygen and chemical probe relay labelling approach demonstrates high selectivity, enabling comprehensive histidine profiling and providing crucial functional insights.

Different deubiquitinases are associated to cancer development. Here, the authors show that PPARgamma is stabilized by USP22-mediated deubiquitination leading to lipid accumulation and promoting hepatocellular carcinoma.

Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses

The ‘Pf’ bacteriophages of Pseudomonas aeruginosa play roles in biofilm formation and virulence. Here, the authors identify a prophage regulatory module, KKP (kinase-kinase-phosphatase), that controls virion production of co-resident Pf prophages and mediates host defense against diverse lytic phages.

All-electrical switching of magnetization holds promise for applications in information technologies with low power consumption. Here, current-induced spin–orbit torque switches the magnetization in SrIrO₃/SrRuO₃ bilayer structures at 70 K in the absence of an external magnetic field.

When an antiferromagnet is in close proximity to a ferromagnet, the antiferromagnet pins the spins of the ferromagnet, resulting in an exchange bias effect. This effect has been instrumental in the development of a variety of spintronic devices. Here, Haung et al. use pressure to tune the exchange bias effect in all van der Waals heterostructure composed of FePSe₃/Fe₃GeTe₂.

Here, authors report a Pt-based catalyst resistant to high concentration CO poisoning for fuel cell applications, making it possible to use reformed hydrogen directly as fuel for fuel cells.

This study uses a unique dataset with intracranial electroencephalography recordings from 18 neurosurgical patients performing a visual search task to uncover neuronal network dynamics and brain regions associated with attentional capture.

RuO₂ is highly active toward the acidic electrochemical oxygen evolution reaction but exhibits instability due to lattice oxygen oxidation. Here, authors prepare an interstitial Si-decorated RuO₂ catalyst with improved stability for acidic water oxidation by suppressing lattice oxygen oxidation.