Optogenetic tools allowing transcranial neural inhibition in treating seizures are limited. This study demonstrates that noninvasive transcranial optogenetic activation of a highly sensitive Kâ+â-conductive channelrhodopsin (HcKCR1-hs) silences neurons and suppresses seizures deep in the brain, alleviating epilepsy symptoms in mouse models, without intracranial surgery.
- Xiaodong Duan
- Chong Zhang
- Kun Song