Nature Search

Publisher Correction: DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice

Guojiao Huang
Zhidan Li
Xuelian He
Amendments and Corrections24 Sept 2024
Nature Neuroscience

Volume: 27, P: 2261
DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice

The mechanisms underlying the ability to remyelinate in aging and disease are unclear. Here, the authors show that DOR-mediated activation of α-ketoglutarate in mature oligodendrocytes can promote myelin production in mice during demyelination and aging.

Guojiao Huang
Zhidan Li
Xuelian He
Research12 Sept 2024
Nature Neuroscience

Volume: 27, P: 2073-2085
The predictive value of triglyceride glucose-body mass index for contrast-induced nephropathy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Litian Liu
Zheng Yuan
Feifei Zhang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Sliding-attention transformer neural architecture for predicting T cell receptor–antigen–human leucocyte antigen binding

Predicting TCR–antigen–human leucocyte antigen binding opens the door to neoantigen identification. In this study, a physics-inspired sliding transformer (PISTE) system is used to guide the positioning of amino acid residues along the gradient field of their interactions, boosting binding prediction accuracy.

Ziyan Feng
Jingyang Chen
Honglin Li
ResearchOpen Access27 Sept 2024
Nature Machine Intelligence

Volume: 6, P: 1216-1230
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Correction: A CRISPR–Cpf1 system for efficient genome editing and transcriptional repression in plants

Xu Tang
Levi G. Lowder
Yiping Qi
Amendments and Corrections19 Jun 2017
Nature Plants

Volume: 3, P: 1
CRISPR–Cas12b enables efficient plant genome engineering

The highly efficient and specific Cas12b is a new tool for genome editing with CRISPR in rice. This system can also be engineered for targeted transcriptional repression and activation.

Meiling Ming
Qiurong Ren
Yiping Qi
Research09 Mar 2020
Nature Plants

Volume: 6, P: 202-208
High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants

Base editors are a powerful but underexplored tool for genetic engineering and directed evolution of plants. Here, the authors investigate the editing efficiency and specificity of TadA-8e-derived cytosine base editors and dual base editor TadDE in rice and tomato.

Tingting Fan
Yanhao Cheng
Yong Zhang
ResearchOpen Access14 Jun 2024
Nature Communications

Volume: 15, P: 1-15
A CRISPR–Cpf1 system for efficient genome editing and transcriptional repression in plants

CRISPR–Cpf1 has emerged as an effective genome editing tool in animals. Now, a study shows that this system can edit plant genomes at nearly 100% efficiency at independent sites. Moreover, it can be repurposed for modulating plant transcriptome.

Xu Tang
Levi G. Lowder
Yiping Qi
Research17 Feb 2017
Nature Plants

Volume: 3, P: 1-5
Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction

Dusp6, an ERK specific phosphatase, was identified as a regenerative repressor during zebrafish heart regeneration. Here, the authors show that Dusp6 deficiency improves post infarctional cardiac repair by predominantly attenuating neutrophil-mediated myocardial damage in mammalian hearts.

Xiaohai Zhou
Chenyang Zhang
Jing-Wei Xiong
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Microglia-organized scar-free spinal cord repair in neonatal mice

In neonatal mice, scar-free healing after spinal cord injury is organized by microglia, and transplantation of neonatal microglia or peptidase-inhibitor-treated adult microglia into adult mice after injury improves healing and axon regrowth.

Yi Li
Xuelian He
Zhigang He
Research07 Oct 2020
Nature

Volume: 587, P: 613-618
Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system

In the field of plant genome engineering, new nucleases with improved editing efficiency and alterative PAM requirements are needed. Here, the authors report a probiotic sourced CRISPR-LrCas9 system with similar PAM requirement to Cas12a and show its high efficiencies in various genome editing applications.

Zhaohui Zhong
Guanqing Liu
Yong Zhang
ResearchOpen Access29 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis

Zhang et al. perform single-cell RNA and B-cell receptor sequencing to characterize the transcriptomic profiles of B-cell acute lymphoblastic leukaemia cells at diagnosis, residual and relapse stages, uncovering the hypoxia pathway as a potential target for residual leukaemia cells.

Yingchi Zhang
Shicheng Wang
Tao Cheng
Research10 Feb 2022
Nature Cell Biology

Volume: 24, P: 242-252
Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Biochemical assays using activity-based chemical probes revealed that the Hippo pathway transcription factor TEAD undergoes autopalmitoylation to ensure binding to YAP/TAZ and promote muscle differentiation and tissue growth.

PuiYee Chan
Xiao Han
Xu Wu
Research22 Feb 2016
Nature Chemical Biology

Volume: 12, P: 282-289
Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems

CRISPR-Cas12a is a promising system for targeting AT-rich regions of the genome. Here the authors identify Cas12a orthologs with expanded targeting scope and develop a highly multiplexable editing system in rice.

Yingxiao Zhang
Qiurong Ren
Yiping Qi
ResearchOpen Access29 Mar 2021
Nature Communications

Volume: 12, P: 1-11
An efficient CRISPR–Cas12a promoter editing system for crop improvement

A CRISPR–Cas12a promoter editing system enabled efficient engineering of quantitative trait variations of grain starch and seed size in rice, and achieved an innovative Green Revolution trait through editing of the OsD18 promoter.

Jianping Zhou
Guanqing Liu
Yong Zhang
Research06 Apr 2023
Nature Plants

Volume: 9, P: 588-604
Machine learning for early diagnosis of Kawasaki disease in acute febrile children: retrospective cross-sectional study in China

Wei Zheng
Shiben Zhu
Xufang Li
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Spatiotemporal manipulation of auxin biosynthesis in cotton ovule epidermal cells enhances fiber yield and quality

It has been extremely challenging to simultaneously improve both the yield and quality of cotton by conventional breeding. Extensive field trials indicate that regulated expression of an auxin biosynthesis gene in the epidermis of cotton ovules improves both the number and fineness of cotton fibers.

Mi Zhang
Xuelian Zheng
Yan Pei
Research10 Apr 2011
Nature Biotechnology

Volume: 29, P: 453-458
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Only one of the three Taenia species causing taeniasis in humans was previously sequenced. Here the authors provide draft genomes of Taenia saginata and Taenia asiatica, analyse genome evolution of all three species, and identify potential targets for developing diagnostic markers or intervention tools.

Shuai Wang
Sen Wang
Xuepeng Cai
ResearchOpen Access22 Sept 2016
Nature Communications

Volume: 7, P: 1-12
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2

Patients with diabetes are more susceptible to suffer from more severe COVID-19. Tong et al. identify a glucose-like metabolite that is reduced in patients with diabetes and has the ability to prevent cellular infection by SARS-CoV-2

Liangqin Tong
Xiaoping Xiao
Gong Cheng
Research09 May 2022
Nature Metabolism

Volume: 4, P: 547-558
PAM-less plant genome editing using a CRISPR–SpRY toolbox

An engineered SpRY Cas9 variant enables efficient gene editing without PAM requirement in rice transgenic lines and Dahurian larch protoplasts, and its derived base editors can edit the rice genome efficiently in a PAM-less fashion too.

Qiurong Ren
Simon Sretenovic
Yong Zhang
Research04 Jan 2021
Nature Plants

Volume: 7, P: 25-33
A dynamic framework for contractors to measure the performance of highway maintenance based on grey theory

Xuelian Wu
Xiaoli Shi
Xiaotian Gong
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-17
Chinese physicians’ perceptions and willingness to use telemedicine during the COVID-19 pandemic

Xuelian Hai
Jia Zhang
Jay Pan
ResearchOpen Access27 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-10
Assessing insurer guarantee cover and risk retention toward SDG 3: a structure-break down-and-out call valuation

Xuelian Li
Shiu-Chieh Chiu
Yuxin Xie
ResearchOpen Access04 Oct 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-10
TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO

Zhou Yu
Xuelian Li
Xuetao Cao
ResearchOpen Access28 Feb 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR

Jiaying Huang
Zhou Yu
Xuetao Cao
ResearchOpen Access04 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-12
IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation

NF-κB inhibitor alpha (IKBA) signaling in mature sperm drives sperm motility and controls fatty acid b-oxidation metabolism.

Yanquan Li
Youwei Hu
Yuchuan Zhou
ResearchOpen Access25 Mar 2023
Communications Biology

Volume: 6, P: 1-12
O-terminated interface for thickness-insensitive transport properties of aluminum oxide Josephson junctions

Zheng Shan
Xuelian Gou
Lin Han
ResearchOpen Access12 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation

Linhui Wu
Ke Yu
Jia Ma
ResearchOpen Access12 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-12
YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD

Mengxue Yu
Yingzhun Chen
Hongli Shan
ResearchOpen Access27 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-13
Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade

Ruixue Wang
Xuelian Zheng
Xia Wang
ResearchOpen Access31 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum

Jun Ju
Qian Liu
Hedong Li
ResearchOpen Access29 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
Selection of suitable reference genes for quantitative real-time PCR gene expression analysis in Salix matsudana under different abiotic stresses

Yunxing Zhang
Xiaojiao Han
Renying Zhuo
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

Liang Huang
Dan Liu
Qian-fei Wang
Research17 Nov 2017
Cell Research

Volume: 28, P: 172-186

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Publisher Correction: DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice

DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice

The predictive value of triglyceride glucose-body mass index for contrast-induced nephropathy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Sliding-attention transformer neural architecture for predicting T cell receptor–antigen–human leucocyte antigen binding

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Correction: A CRISPR–Cpf1 system for efficient genome editing and transcriptional repression in plants

CRISPR–Cas12b enables efficient plant genome engineering

High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants

A CRISPR–Cpf1 system for efficient genome editing and transcriptional repression in plants

Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction

Microglia-organized scar-free spinal cord repair in neonatal mice

Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system

Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems

An efficient CRISPR–Cas12a promoter editing system for crop improvement

Machine learning for early diagnosis of Kawasaki disease in acute febrile children: retrospective cross-sectional study in China

Spatiotemporal manipulation of auxin biosynthesis in cotton ovule epidermal cells enhances fiber yield and quality

Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2

PAM-less plant genome editing using a CRISPR–SpRY toolbox

A dynamic framework for contractors to measure the performance of highway maintenance based on grey theory

Chinese physicians’ perceptions and willingness to use telemedicine during the COVID-19 pandemic

Assessing insurer guarantee cover and risk retention toward SDG 3: a structure-break down-and-out call valuation

TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO

Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR

IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation

O-terminated interface for thickness-insensitive transport properties of aluminum oxide Josephson junctions

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation

YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD

Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade

Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum

Selection of suitable reference genes for quantitative real-time PCR gene expression analysis in Salix matsudana under different abiotic stresses

Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

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