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Showing 1–50 of 57 results

Advanced filters: Author: Xueyi Chen Clear advanced filters

A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

Xueyi Shen
Miruna Barbu
Andrew M. McIntosh
ResearchOpen Access16 Sept 2025
Nature Mental Health

Volume: 3, P: 1152-1167
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection

Yin, Lin, Cai, Nie and colleagues report phase separation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in cancer.

Yixin Yin
Jinlong Lin
Muyan Cai
ResearchOpen Access05 Sept 2025
Nature Cell Biology

P: 1-14
Safety and efficacy of one-dose nocturnal levetiracetam for the treatment of self-limited epilepsy with centrotemporal spikes: a randomized clinical trial

Lijuan Fan
Yajun Shen
Rong Luo
ResearchOpen Access01 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
¹⁸F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies

In this study, the authors describe an imaging technology, ¹⁸F-FDS PET, for noninvasive detection, localization and monitoring of invasive mold infections, including Aspergillus, non-Aspergillus and azole-resistant molds, throughout the body.

Carlos E. Ruiz-Gonzalez
Oscar J. Nino-Meza
Sanjay K. Jain
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

Mitochondria play a key role in cellular metabolism. Here, authors develop a Variational Autoencoder to design novel mitochondrial targeting sequences, validating them across several eukaryotic organisms and demonstrating their utility in metabolic engineering and protein delivery.

Aashutosh Girish Boob
Shih-I Tan
Huimin Zhao
ResearchOpen Access04 May 2025
Nature Communications

Volume: 16, P: 1-16
The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy

Delivering plasmid DNA to solid tumors is challenging since it demands more transport steps than other genetic materials. Here this group designs a hybrid lipoplex for co-delivering p53 plasmid along with MDM2 inhibitor sp141 to hepatocellular carcinoma and lung carcinoma for synergistic anti-tumor treatment.

Xueyi Hu
Yichun Wang
Xintao Shuai
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs

Antibiotic treatments for tuberculous meningitis, the deadliest form of tuberculosis, are not optimized. Here, PET in human and animal studies is used to measure the biodistribution of several antibiotics to develop optimized regimens for drug-resistant tuberculous meningitis.

Xueyi Chen
Bhavatharini Arun
Sanjay K. Jain
ResearchOpen Access14 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Structural characterization and immunomodulatory activity of a polysaccharide produced by chaetomium globosum CGMCC 6882

Shuaiyang Wang
He Chang
Shaobo Duan
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Parents’ information needs and perceptions of chatbots regarding self medicating their children

Xueyi Wei
Xiuwen Chen
Peng Liao
ResearchOpen Access21 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

Mycobacterium tuberculosis prevents host-cell apoptosis, causing necrosis and fibrosis, leading to tissue damage. Singh et al. show that strategic targeting of apoptosis with Bcl-2 inhibitors may enhance TB treatments and be protective against post-TB lung disease.

Medha Singh
Mona O. Sarhan
Sanjay K. Jain
ResearchOpen Access27 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Single-cell RNA sequencing technology offers a unique opportunity to dissect cell heterogeneity of animals. Here, the authors construct a Xenopus cell landscape including larval and adult organs to dissect cell heterogeneity of the amphibian.

Yuan Liao
Lifeng Ma
Xiaoping Han
ResearchOpen Access25 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Physiological response of safflower to water deficit and genome-wide identification of its NAC transcription factor family

Jialing Yang
Long Han
Linna Du
ResearchOpen Access25 Aug 2025
Scientific Reports

Volume: 15, P: 1-17
Publisher Correction: Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Yuan Liao
Lifeng Ma
Xiaoping Han
Amendments and CorrectionsOpen Access01 Sept 2022
Nature Communications

Volume: 13, P: 1
Deep learning of cross-species single-cell landscapes identifies conserved regulatory programs underlying cell types

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

Jiaqi Li
Jingjing Wang
Guoji Guo
Research13 Oct 2022
Nature Genetics

Volume: 54, P: 1711-1720
A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

Epstein–Barr virus-associated gastric cancer shows a robust response to immune checkpoint inhibitors. Here the authors introduce a deep convolutional neural network and its fusion with pathologists for predicting it from histopathology.

Xueyi Zheng
Ruixuan Wang
Muyan Cai
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-12
Preemptive interferon-α treatment could protect against relapse and improve long-term survival of ALL patients after allo-HSCT

Sining Liu
Xueyi Luo
Xiaodong Mo
ResearchOpen Access19 Nov 2020
Scientific Reports

Volume: 10, P: 1-11
Prognostic Value of Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma: a Meta-analysis

Zhaona Fan
Mianxiang Li
Juan Xia
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

Oxygen is an essential requirement for aerobic organisms. Here the authors explore the role of oxygen in the antiviral innate response in multiple models of infection and suggest oxygen enhances the antiviral innate response via EGLN1 hydroxylation of IRF3.

Xing Liu
Jinhua Tang
Wuhan Xiao
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-21
An end-to-end multifunctional AI platform for intraoperative diagnosis

Xueyi Zheng
Ke Zheng
Muyan Cai
ResearchOpen Access20 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-12
A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma

Correct diagnosis of primary central nervous system lymphoma is key in determining treatment, however, this depends on pathology analysis. Here, the authors develop a deep learning method to diagnose primary nervous system lymphoma from stained whole-slide images.

Xinke Zhang
Zihan Zhao
Muyan Cai
ResearchOpen Access04 May 2024
Nature Communications

Volume: 15, P: 1-15
Integrated analysis of MIOX gene in prognosis of clear-cell renal cell carcinoma

Yiqiu Wang
Jiayi Lu
Ning Xu
ResearchOpen Access08 May 2025
Cell Death & Disease

Volume: 16, P: 1-10
Slight compositional variation-induced structural disorder-to-order transition enables fast Na⁺ storage in layered transition metal oxides

In layered transition metal oxides as cathode active materials for Na-ion batteries, Na⁺ diffusion kinetics are impacted by Na⁺/vacancy ordering. Here, the authors suggest that the P2-type Na_2/3Ni_1/3Mn_2/3O₂ with large zigzag ordering exhibits high Na⁺ mobility and thus superior rate capability.

Yuansheng Shi
Pengfeng Jiang
Xia Lu
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-12
Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Addictive substances may impair cognitive flexibility. Here the authors show that in rodents, increased activity of striatal direct-pathway medium spiny neurons (dMSNs) in response to cocaine inhibits cholinergic interneurons (CINs), reducing cognitive flexibility.

Himanshu Gangal
Xueyi Xie
Jun Wang
ResearchOpen Access30 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Dynamic ¹⁸F-Pretomanid PET imaging in animal models of TB meningitis and human studies

Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomography in animal models, and human studies.

Filipa Mota
Camilo A. Ruiz-Bedoya
Sanjay K. Jain
ResearchOpen Access29 Dec 2022
Nature Communications

Volume: 13, P: 1-9
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures

This analysis leverages experimentally sequenced data and in silico mixtures to simulate transcript expression differences, which enables a performance assessment of long-read tools developed for isoform detection, differential transcript expression analysis and differential transcript usage analysis.

Xueyi Dong
Mei R. M. Du
Matthew E. Ritchie
Research02 Oct 2023
Nature Methods

Volume: 20, P: 1810-1821
The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Here the authors characterize the sequence-specific effect of an anticancer compound on mRNA cleavage, providing insights into the mechanism of mRNA 3′ processing.

Liang Liu
Angela M Yu
Yongsheng Shi
Research12 Dec 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1947-1957
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure.

Vaibhav B. Patel
Pavel Zhabyeyev
Gavin Y. Oudit
ResearchOpen Access19 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Optimal Gestational Weight Gain for Tibetans Based on Prepregnancy Body Mass Index

Dajie Chen
Xianxian Zhou
Zuxun Lu
ResearchOpen Access01 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Corneal epithelial changes following reconstruction by transplantation of limbal stem cells in goats with total limbal stem cell deficiency

Shengli Mi
Zhongying Dou
Jinlian Hua
Research04 Aug 2008
Cell Research

Volume: 18, P: S72
Characterization of growth and differentiation of goat limbal adult stem cells in vivo and ex vivo

Shengli Mi
Zhongying Dou
Jinlian Hua
Research04 Aug 2008
Cell Research

Volume: 18, P: S74
Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a goat model

Shengli Mi
Zhongying Dou
Jinlian Hua
Research04 Aug 2008
Cell Research

Volume: 18, P: S73
Transplantation of ex vivo expanded stem cell amniotic sheet for ocular surface reconstruction

Shengli Mi
Zhongying Dou
Jinlian Hua
Research04 Aug 2008
Cell Research

Volume: 18, P: S75
Correction: Corrigendum: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Amendments and Corrections27 May 2015
Nature Genetics

Volume: 47, P: 689
Short-term changes in brain networks and cognition in children with frontal lobe lesions treated solely with neurosurgical procedures

Xueyi Guan
Bohan Hu
Jian Gong
ResearchOpen Access02 Dec 2024
Scientific Reports

Volume: 14, P: 1-13
Author Correction: Sparse whole-genome sequencing identifies two loci for major depressive disorder

N. A. Cai
Tim B. Bigdeli
Jonathan Flint
Amendments and Corrections11 Aug 2023
Nature

Volume: 620, P: E28
Integrated analysis of proteomics and metabolomics in infantile epileptic spasms syndrome

Jun Chen
Xiaoqian Wang
Jing Gan
ResearchOpen Access06 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Proactive personality and its impact on online learning engagement through positive emotions and learning motivation

Pingting Fu
Chengjin Gao
Dong Yang
ResearchOpen Access15 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung, Chiea-Chuen Khor and colleagues report the results of a genome-wide association study of exfoliation syndrome. They replicate a known association at LOXL1 and identify a previously unreported association at CACNA1A.

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Research23 Feb 2015
Nature Genetics

Volume: 47, P: 387-392
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
Author Correction: Multiple omics integrative analysis identifies GARS1 as a novel prognostic and immunological biomarker: from pan-cancer to bladder cancer

Weihui Liu
Chengcheng Wei
Xueyi Xue
Amendments and CorrectionsOpen Access24 Oct 2024
Scientific Reports

Volume: 14, P: 1
NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib

Zheng Chen
Xiangyu Wei
Xuesheng Zheng
ResearchOpen Access07 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-15
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress

Xueyi Chen
Linglu Qi
Zhice Xu
Research07 Jan 2019
Hypertension Research

Volume: 42, P: 863-875
Sparse whole-genome sequencing identifies two loci for major depressive disorder

Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene.

Na Cai
Tim B. Bigdeli
Jonathan Flint
Research15 Jul 2015
Nature

Volume: 523, P: 588-591
Multiple omics integrative analysis identifies GARS1 as a novel prognostic and immunological biomarker: from pan-cancer to bladder cancer

Weihui Liu
Chengcheng Wei
Xueyi Xue
ResearchOpen Access16 Aug 2024
Scientific Reports

Volume: 14, P: 1-21
LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer

Jian Xu
Jie Wang
Jianxin Jiang
ResearchOpen Access24 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-13
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma

Qingqing Yang
Xiangrui Meng
Xudong Wu
ResearchOpen Access05 Dec 2023
Cell Death Discovery

Volume: 9, P: 1-13
S1PR1 regulates the switch of two angiogenic modes by VE-cadherin phosphorylation in breast cancer

Shuang Liu
Chunsheng Ni
Baocun Sun
ResearchOpen Access27 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-15
NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas

Zheng Chen
Shiting Li
Xuesheng Zheng
ResearchOpen Access07 May 2020
Cell Death & Disease

Volume: 11, P: 1-18

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