Search

The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin remodeling, DNA repair, and cell cycle progression.

Skeletal muscle contractions are regulated by a process known as excitation–contraction coupling (ECC), defects in which can cause myopathies. Here Horstick et al.show that the protein STAC3 is a component of the ECC machinery and identify mutations in STAC3 as the cause of Native American Myopathy.

How Indigenous populations in the southern tip of South America have changed over time has been unclear. Here the authors generate genome-wide data for 20 ancient individuals and examine how past migrations and admixture events correlate to geography and shifts in the archaeological record.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, causing upregulation of defense mechanisms that promote longevity.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Here, Kasaragod et al. solve structures of the GABA_A receptor α5 subunit in complex with different classes of positive and negative allosteric modulators to explain the binding modes and the molecular basis of selectivity.

Horses have lived in Iberia since the Ice Age. Using ancient genomes to study their history, Lira Garrido et al. reveal a local wild lineage lasting until Late Iron Age, and highlight the far-reaching influence of Iberian bloodlines across Europe and north Africa during the Iron Age and beyond.

Ahmed et al. show that lysine demethylase 8 (Kdm8) maintains the homeostatic cardiac metabolism by repressing Tbx15, thus preventing dilated cardiomyopathy in mice. In humans, KDM8 was downregulated in hearts affected by dilated cardiomyopathy, and higher TBX15 expression correlated with the strongest downregulation of genes encoding mitochondrial proteins.

The timing of NAD + supply determines its efficacy to treat metabolic disease. Here, the authors show that increasing NAD + at the early active phase maximizes weight loss and glucose regulation in mice. NAD + can displace the phase of the liver clock which can cause circadian misalignment.

Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging.

Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to induce mitochondrial fusion.

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

Variations in the seasonal cycle of temperatures at the Earth's surface are spatially mapped on both land and sea, and trends in the recent past (1954–2007) are compared with those occurring earlier (1900–1954). Assuming that the earlier part of the temperature record is dominated by natural variations, the recent trends seem highly anomalous: temperatures on land show a shift to earlier seasons by 1.7 days, and the amplitude of the cycle has decreased in this period.

Current efforts to enhance NMR signals using the signal amplification by reversible exchange (SABRE) focus on optimizing polarization transfer from parahydrogen-derived hydride ligands to the substrate, but this requires quantitative information on ligand exchange rates, which common NMR techniques struggle to provide. Here, the authors introduce an experimental spin order transfer sequence with readout occurring at hyperpolarization-enhanced ¹⁵N nuclei that are directly interacting with the SABRE catalyst, enabling robust evaluation of ligand chemical exchange.

Food biodiversity is likely to benefit both human health and agrifood systems. To assess food biodiversity, this epidemiological study proposes the use of dietary species richness, which is highly heterogeneous—both between and within countries—and is associated with lower rates of mortality in Europe and similar levels of micronutrient adequacy in low- and middle-income countries, as opposed to other classical indices.

Stereoselective synthetic routes use P3HB (a polyester produced by bacteria) as a chiral feedstock for related polymers that have properties more amenable to processing and use.

High-resolution satellite observations provide an accurate and cost-effective solution to monitoring national and global progress towards Sustainable Development Goals. With a new global cropland dataset, this study reports that during the first two decades of the twenty-first century, the global cropland area increased by 9%, whereas the per-capita cropland area decreased by 10% and the per-capita annual cropland net primary production increased by 3.5%.

We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.

Highly pathogenic avian influenza viruses from H5 clade 2.3.4.4b are circulating widely in birds and have recently caused large outbreaks in mammals. Here, Furey et al. develop a clade 2.3.4.4b HA-expressing mRNA-LNP vaccine and show that it elicits strong protective immune responses in mice and ferrets.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Whole genome sequencing (WGS) data on non-European and admixed individuals remains scarce. Here, the authors analyse WGS data from 1,171 admixed elderly Brazilians from a census cohort, characterising population-specific genetic variation and exploring the clinical utility of this expanded dataset.

The cell cycle regulator CDK1 phosphorylates the acetyltransferase TIP60, which subsequently acetylates the mitotic regulator Aurora B to ensure chromosomal segregation. Aurora B acetylation prevents inactivation by PP2A-mediated dephosphorylation.

Acetylome and proteome data analysis across 107 mammalian species identifies significant longevity-associated acetylated lysines. This study proposes a link between protein acetylation conservation and changes in mammalian longevity during evolution.

An Oryza-specific histone H4 variant (H4.V) forms condensed, less stable nucleosomes. H4.V enhances the salt-stress-dependent deposition of H4 lysine 5 acetylation marks at several protein-coding loci, thereby regulating the salt stress transcriptome.

The growing complexity of quantum computing devices makes presents challenges for benchmarking their performance as previous, exhaustive approaches become infeasible. Here the authors characterise the quality of their 11-qubit device by successfully computing two quantum algorithms.

Whole-genome sequences and field experiments focusing on the global invasive forage crop, Trifolium repens, show high levels of genetic variation across continents and parallel signatures of selection in five haploblocks.

Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of adipose S-adenosylmethionine and NAD⁺, rendering Nnmt a novel target for treating obesity and type 2 diabetes.

Efficient protocols for comparing quantum states generated on different quantum computing platforms are becoming increasingly important. Zhu et al. demonstrate cross-platform verification using randomized measurements that allow for scaling to larger systems as compared to full quantum state tomography.

Paired electrosynthesis is an efficient green process that minimizes resource and energy consumption as well as waste generation. The authors demonstrate an electrolysis system that pairs CO₂ reduction to CO at the cathode with allyl alcohol oxidation to acrolein at the anode.