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Multi-donor molecules in Si provide a promising qubit platform, offering advantages over single donor qubits in terms of performance and fabrication. Here, the authors report a single qubit gate and long coherence times in a P donor molecule qubit in natural Si patterned by scanning tunneling microscope hydrogen lithography.

TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

Despite recent advances with trappedion-based platforms, achieving quantum networks with link efficiency greater than unity on metropolitan scales is still a challenge. Here, the authors demonstrate a multiplexed quantum network generating heralded entanglement at a rate faster than local decoherence.

A new technological development for detecting floating litter from space was tested in the Mediterranean Sea. Using satellites currently in orbit, researchers achieved an unprecedented view of the emissions and accumulation areas of marine litter.

The effects of detection noise on quantum metrology performances have not been rigorously investigated yet. Here, the authors fill this gap by generalising the quantum Fisher information to the case of noisy readout, and showing the consequences the imperfect measurements bring.

The LHCb collaboration reports an improved measurement of the oscillation frequency of mesons consisting of a bottom quark and strange quark, which is then combined with previous results.

Exceptional preservation of periostracum in Lower Cretaceous ammonoids collected from the foothills of the southern Andes sheds light on its morphology and chemical composition revealing that this is a very conservative structure among molluscs.

The ability to engineer novel protein structures has tremendous scientific and therapeutic impact. Here, authors develop a generative model acting upon an angular representation of protein structures to create high quality protein backbones.

A challenge of magnetically-actuated devices is to obtain different behaviours from each component under the same driving field. Here the authors tune the dipolar interactions between rotors to obtain different rotational behaviours when actuated by a magnetic field leading to complex collective dynamics.

An antimatter hypernucleus formed by an anti-lambda hadron, an antiproton and two antineutrons was observed through its two-body decay after production in ultrarelativistic heavy-ion collisions.

Jupiter’s magnetodisk mediates mass, momentum, and energy exchange between Jupiter’s atmosphere, ionosphere, magnetosphere, and moon tori. Here, the authors show that pressure anisotropy-driven instabilities regulate its nonequilibrium dynamics.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

The activity of the voltage-sensitive phosphatase from Ciona intestinalis, VSP, towards PIP3 and PIP2 is dictated by the sequential switching between two active conformations of the phosphatase domain that is also correlated with conformational changes in the voltage sensor.

The anomalous Hall effect (AHE) occurs in ferromagnets caused by intrinsic and extrinsic mechanisms. Here, Yoo et al. report large anomalous Hall conductivity and Hall angle at the interface between a ferromagnet La_0.7Sr_0.3MnO₃ and a semimetallic SrIrO₃, due to the interplay between correlated physics and topological phenomena.

The growing complexity of quantum computing devices makes presents challenges for benchmarking their performance as previous, exhaustive approaches become infeasible. Here the authors characterise the quality of their 11-qubit device by successfully computing two quantum algorithms.

The trade-off between long lifetime and inevitable radiative decay to a control line has become a key limitation for superconducting qubits. Here, the authors break the trade-off by coupling another qubit to the control line of the first one to suppress its relaxation, while enabling fast qubit control.

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

The decay asymmetry and helicity phase of polarized baryon–antibaryon pairs are measured at the BESIII experiment, testing charge–parity symmetry and revealing a discrepancy of the Λ → pπ⁻ decay asymmetry with respect to the current world average.

Carnitine uptake by OCTN2 supports fatty acid metabolism. Here, authors report cryo-EM structures of human OCTN2, revealing the mechanism of sodium ion-dependent carnitine transport and providing insight into disease-associated variants.

This study demonstrates that growth arrest under stress in Arabidopsis protects meristem cells from DNA damage, challenging the idea that it is merely due to energy trade-offs and highlighting its role as an active defense strategy.

Many approaches exist to process data from individual imaging modalities, but integrating them is challenging. The authors develop an automated resource that enables co-registered network- and tract-level analysis of macroscopic in-vivo imaging and microscopic imaging of cleared tissue.

Superconductivity mediated by phonons is usually conventional due to isotropic electron-phonon coupling. Here, Wang et al. report highly anisotropic phonons only along [001] direction in Sr_0.1Bi₂Se₃, indicating a singular electron-phonon coupling which favors a p-wave nematic superconductivity scenario.

Parallel operation of two exchange-only qubits consisting of six quantum dots arranged linearly is shown to be achievable and maintains qubit control quality compared with sequential operation, with potential for use in scaled quantum computing.

Structured light has proven useful for numerous photonic applications. However, its current use in optical fibers is severely limited. The authors report a highly integrated metafiber platform based on 3D laser nanoprinting, capable of creating arbitrarily structured light.

Examples of photoinduced insulator-to-metal transitions with a long-lived metallic state are rare. Here, the authors report a photoinduced steady metallic state in Ta₂NiSe₅, characterized by a lattice structure distinct from that of equilibrium states and thermally stable up to 350 K.

Device-independent quantum key distribution aims at the ultimate quantum-based unconditional security, but current protocols’ rates are quite far from anything practical. The authors’ protocol narrows this gap by using two randomly chosen key generating bases instead of one.

Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.

Magnetospheric substorms are powerful space weather events with debated onset mechanisms. Here, the authors show that new radio precursors of auroral kilometric radiation coincide with wave-like aurora and reveal Alfvénic processes before substorm onset.

Somatic mutations accumulate with age and have been linked to functional decline and disease. Single-cell analysis of human cartilage samples from donors with and without osteoarthritis shows that somatic mutations accumulate with age, but, in osteoarthritis, they show distinct mutational patterns and slower accumulation, possibly due to DNA-damage-induced chondrocyte death.

Reconfigurable electronic devices that can be shaped in two or more stable geometries modifying their functionalities have been realized by engineering the sequence in which the elastomeric substrates are mechanically buckled.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial perception in mice.

The suboptimal performance of perovskite solar cells based on non-fullerene acceptor as the electron-transporting layer underscores the need for their molecular engineering. Here, authors substitute the core of Y6 with phenanthroline and crown ether, achieving a certified efficiency of 25.59%.

An investigation of the use of nonlinear upconversion effects like second-harmonic generation and four-wave mixing within biological tissue indicates that it should be possible to perform photodynamic therapy with near-infrared laser light at greater depths than previously.

This study introduces a label-free imaging and machine learning platform that predicts hematopoietic stem cell function based on their dynamic behaviors, offering new insights into stem cell diversity and potential clinical applications.

In a randomized controlled trial that included 97 participants, 69% patients with Crohn’s disease (CD) allocated to a fasting-mimicking diet (FMD) achieved clinical response, and over 60% reached remission, outperforming the control group. The FMD also reduced markers of intestinal inflammation, suggesting this dietary intervention could serve as adjunctive treatment for CD.

How landscapes are arranged affects soil pathogenic fungi worldwide. The authors reveal the global pattern and pronounced scale-dependency of landscape complexity and land-cover quantity on soil pathogenic fungal diversity.

Accurately predicting the optimal pH level for enzyme activity is challenging due to the complex relationship between enzyme structure and function. Gado and colleagues show that a language model can effectively learn the structural and biophysical features to predict the optimal pH for enzyme activity.

An artificial intelligence model defines a data-driven set of total parenteral nutrition compositions to assist clinicians in personalized treatment of neonates in intensive care and is able to adapt recommendations to patient status, with validation from large external cohorts and a blinded reader study.

Here, using pre-HIV-infection and non-HIV samples in a multi-modal study of microbiomes and metabolomes, the authors develop a taxon-specific measure of DISruption in COrrelations (DISCO) revealing system-wide dysbiosis preceding HIV-1 infection in men who have sex with men.

Wearable sensors typically require innovative methods of energy harvesting for low-power electronics. Here, the authors present an adaptive power management system with a trimodal energy harvesting approach.

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

An ultrathin, needle-shaped piezoelectric microsystem that can be injected or mounted onto conventional biopsy needles measures variations in tissue modulus in real time and can thus be used to distinguish abnormal from healthy tissue.

An electronic skin that is capable of long-term monitoring of vital signs and molecular biomarkers in sweat can—with the help of machine learning—be used to classify stress responses with high accuracy and predict state anxiety levels with high reliability.

Terahertz absorption reduces the viscosity of the hydrodynamic electron fluid in graphene and thereby enables easier flow of electrons. This results in a drop in resistance within graphene constrictions under terahertz radiation, facilitating fast and sensitive terahertz detection.