Vesicular monoamine transporter 2 (VMAT2) plays a pivotal role in the packaging of monoamine neurotransmitters, including serotonin and dopamine, into synaptic vesicles. Here, the authors present the structures of VMAT2 in complex with substrates 5-HT and DA, as well as the inhibitors TBZ and VBZ, providing insights into the mechanisms of transport and inhibition.
- Feiwen Wei
- Huihui Liu
- Yanqing Zhang
