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Chronic wounds typically exhibit dynamic variations within the complex wound microenvironment over time. Here, Cheng et al. develop a microenvironment-feedback hydrogel to achieve homeostatic wound pH and blood glucose levels to accelerate repair of diabetic chronic wounds.

ALOX5 contributes to the tubular injury in IRI-induced AKI through enhancing ferroptosis in the renal tubular cells and might be a novel target for the prevention and treatment of IRI-induced AKI.

The authors demonstrate that high-precision birefringence detection at the 10⁻¹¹ level can be achieved using spin-orbit-coupled Rabi oscillations in a photonic two-level system. The presented detection technique benefits a broad range of applications involving optical birefringence such as precise control of the entangled photonic states.

VS₂ is a promising cathode material for lithium-ion batteries, but is susceptible to Peierls distortion during (de)lithiation. Here the authors show that VS₂ cathodes can be stabilized by conformally coating them with a nanoscale TiS₂ protective layer, leading to impressive electrochemical performance.

Dirac semimetals have been proposed as parent materials for other topologically non-trivial phases such as Weyl semimetals, achieved by the breaking of time reversal symmetry. Here the authors use transport measurements to evidence such behaviour in single crystal Cd₃As₂under an applied magnetic field.

A low-loss cavity is shown to store X-ray laser pulses for >2.8 μs.

This study of 9,997 Chinese children (2013–2015) found that solid fuel exposure led to marginally significant declines in lung function, with higher risk for children with persistent exposure or allergies, highlighting the need for clean fuel use.

The RNA methyltransferase activity of SPOUT1/CENP-32 is crucial for accurate mitotic spindle organization. Here, the authors describe a neurodevelopmental disorder caused by bi-allelic pathogenic SPOUT1 variants with reduced activity and compromised function in spindle organization.

Owing to strong Coulomb interactions, atomically thin transition metal dichalcogenides host strongly bound excitonic complexes. Here, the authors report charge-neutral biexciton and negatively charged trion-exciton complexes in hBN encapsulated monolayer WSe₂ by employing low-temperature photoluminescence spectroscopy.

Peptides encoded by noncanonical open reading frames play important roles in cancer. Here the authors identify that a microprotein HDSP derived from the long non-coding RNA HOXA10-HOXA9 is overexpressed in gastric cancer and forms a positive feedback loop with MECOM to drive EGFR signaling in gastric cancer progression.

The authors present a deep learning model that incorporates co-plane attention across image sequences with a performance comparable to senior radiologists in classifying 12 knee abnormalities from MRI. The model significantly improves diagnostic performance and aligns with clinical observations.

STRaM is an advanced bioinformatic pipeline for handling complex engineered-cell and cell-line provenance. Our automated system evaluates similarity index, purity index, editing/mutation index for cell products identification and traceability.

The aryl hydrocarbon receptor, AhR, can regulate Oct4, which is often expressed in cancer stem cells and promotes pluripotency and tumorigenesis. Here, in cancer stem cells, AhR is shown to be activated by the tryptophan derivative ITE, which causes transcriptional repression of Oct4 and reduced tumorigenesis.

A challenge for synthetic biology is the design and construction of prototissue. Here, the authors spatially segregate layers of enzyme-decorated coacervate protocells as a model prototissue capable of chemical signal processing and modulating outputs of nitric oxide to inhibit blood clot formation.

A transition from ballistic to diffusive motion within 10 ps is observed in supercritical carbon dioxide with X-ray photon correlation spectroscopy. Collisions of unbound molecules with clusters are responsible for the ultrafast momentum exchange.

Bacterial allosteric transcription factors can sense and respond to a variety of small molecules. Here the authors present CaT-SMelor which uses Cas12a and allosteric transcription factors to detect small molecules in the nanomolar range.

Brassinosteroids play vital role in plant growth and development. Here, the authors demonstrate that the plasma membrane-associated copine proteins are new components required for the receptor complex functioning in BR signaling in maize and Arabidopsis.

Acral melanoma (AM) is a rare melanoma subtype with unique features, where lymph node metastasis is closely associated with clinical outcomes. Here, the authors use single-cell and spatial transcriptomics to analyse early dissemination, tumour microenvironment, and heterogeneity in AM, and infer metabolic shifts with therapeutic implications.

Laser ablation is a phenomenon where the fundamental research directly intersects with practical relevance for industrial applications, yet probing the highly nonequilibrium phase decomposition triggered by laser excitation is still a challenge. This study provides unique insights into the dynamics of nanoscale phase decomposition in laser ablation of thin gold films by combining time-resolved femtosecond X-ray probing with large-scale atomistic modeling.

Crohn’s disease (CD) is a complex disease associated with immune dysregulation. Here the authors use multimodal data to identify and characterize an epithelial cell population, termed ‘LND’ cells, in both terminal ileum and ascending colon, with LND interacting locally with immune cells and potentially contributing to CD pathology.

3D-printed glass holds great potential. However, it is challenging to control both the dimension and the resolution of the printed material. Here, authors present a one-photon 3D printing approach to produce high-performance fused silica glass with sub-micron resolution and millimetric dimensions.

Liu et al. describe mitopherogenesis: the secretion of mitochondria in mitophers during sperm development in Caenorhabditis elegans, which is important to control the mitochondrial pool and ensure fertility.

Analysis of large-scale representative data from the Chinese National Transgender Survey finds that exposure to gender identity conversion practice is a risk factor for mental health problems, worsens mental health disorder severity and increases suicidality.

Ebola virus virion protein 35 (VP35) is a cofactor of the viral RNA-dependent RNA polymerase, required for viral assembly and IFN antagonist. Here, Zhu et al. provide evidence that EBOV VP35 induces an AKIP1-mediated (human A kinase interacting protein) activation of the PKA-CREB1 signaling pathway and contributes to viral replication and pathogenesis in vitro and in vivo.

A three-dimensional spectroscopic sensor is demonstrated that uses a polarization-resolved scattering technique to determine the location and orientation of small particles. It exploits strong Fano resonance between a pair of particles, one barely visible and another that is relatively bright, to obtain nanoscale orientation information.

The self-assembly of haemoglobin-containing erythrocyte membrane fragments onto the surface of preformed coacervates has been used to make hybrid synthetic cells that can initiate nitric-oxide-induced vasodilation. These synthetic cells encapsulate enzymes that generate a flux of nitric oxide, as well as exhibiting high haemocompatibility and increased blood circulation times.

Paternal environmental inputs can influence various phenotypes in offspring, with important implications for basic biology and public health. Here the authors show that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.

Magnetotransport signature of topological semimetal states has been observed but restricted at very low temperature. Here, Zhanget al. report magnetic field-modulated chiral charge pumping and valley diffusion in Cd₃As₂up to room temperature.

mRNAs are known to be decorated with m5C at a low-to-medium level. Here, the authors generate atlases of mRNA m5C during animal development in 6 species and identify convergent and unexpected massive methylation of maternal mRNAs by NSUN2 and NSUN6.

The Human Breast Cell Atlas identifies 12 major breast cell types and 58 biological cell states, revealing abundant pericyte, endothelial and immune cell populations, and highly diverse luminal epithelial cell states.

Long non-coding RNAs (lncRNA) constitute a large fraction of human transcriptome, and are reported, individually, for context-specific regulatory functions. Here the authors expand our understanding by providing a systemic, unbiased annotation of lncRNA to establish an atlas of lncRNA landscape during the induction of human humoral immune responses.

Lumped circuit elements provide a simple tool to design complex electronic systems; a similar approach has been proposed for nanophotonics. Here, the authors demonstrate the modularized design and assembly of photonic nanocircuits using metal and dielectric nanoparticles as the constituent lumped elements.

It has been predicted that the presence of strong electronic correlations may generate new phases in materials with topologically non-trivial band structure. Here, the authors demonstrate the generation of Dirac mass in the correlated Dirac semimetal candidate ZrTe₅under high magnetic fields.

How the carriers behave in a Weyl semimetal if they occupy the lowest Landau level remains elusive. Here, the authors report evidences of electrons occupying zeroth chiral Landau levels with distinct linear dispersion behaviors for two inequivalent Weyl nodes in a Weyl semimetal NbAs.

High mobility and high carrier density are found in the Weyl semimetal NbAs. This is attributed to the low dissipation of disorder-tolerant Fermi arcs.

A new type of cyclotron orbit combining surface Fermi arcs and bulk states in topological semimetals has recently been proposed as Weyl orbit. Here, Zhang et al. report the evolution of Shubnikov-de Haas oscillations in Dirac semimetal Cd₃As₂ nanoplates along with a quantum Hall state possibly arising from such Weyl orbit.

Rapid dehydration and garnet growth can induce supralithostatic fluid overpressure with important implications for tectonic reconstructions and seismic behaviors, according to thermobarometry and geochronology data from Proterozoic metapelites from Northern Korea.