Search

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Copper component is introduced into MOR zeolites via in situ high-temperature crystallization to tune pores for N₂/CH₄ sieving. MOR-Cu-210 exhibits high N₂ adsorption capacity and N₂/CH₄ uptake ratio, alleviating the capacity-selectivity trade-off.

Coffee has been associated with reduced colorectal cancer incidence. Here, the authors show that caffeine inhibits the kynurenine pathway, boosting CD8⁺ T-cell immunogenic activity, which impairs colorectal cancer progression and enhances immunotherapy response.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

Photonic memristor arrays fabricated from hexagonal boron nitride/silicon heterostructures provide a scalable, silicon-compatible solution for artificial vision systems, featuring broad spectral reconfigurability and promising performance characteristics.

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

Honeybee behavioral plasticity provides a model to study how brain gene networks regulate behavior. Here, authors show stripe activation in Kenyon cells links gene regulatory networks to behavioral maturation via spatial-cellular coordination.

Neuronal PRDX-2-mediated reactive oxygen species (ROS) signaling in C. elegans AWC neurons triggers intestinal mitochondrial stress response, halting digestion to reduce cellular stress. This discovery reveals a brain-gut pathway regulating food intake via ROS signaling.

Intestinal TM6SF2 is found to interact with fatty acid-binding protein 5 to modulate the secretion of fatty acids and the composition of the gut microbiota, thereby protecting against metabolic dysfunction-associated steatohepatitis.

Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.

PD-L1 expression on the surface of cancer cells is believed to contribute to tumor immune evasion via triggering the inhibitory T cell co-receptor, PD-1, resulting in decreased T cell cytotoxicity. Here authors show that OTUB2 regulates PD-L1 expression via inhibition of its ubiquitin-mediated degradation, and that OTUB2 inhibition increases T cell cytotoxicity directed against tumors.

Artificial metalloenzymes (ArMs) often have sensitive metal centers. Here the authors enhance ArM performance by inducing liquid–liquid phase separation in Escherichia coli, creating protective compartments. This strategy boosts ArM loading, stabilizes activity and enables in vivo applications.

Deconvolution methods infer levels of immune infiltration from bulk expression of tumour samples. Here, authors assess 6 published and 22 community-contributed methods via a DREAM Challenge using in vitro and in silico transcriptional profiles of admixed cancer and healthy immune cells.

By integrating split ferroelectric capacitors with complementary characteristics in the same memory cell, this architecture tackles the problem of conflicting memory requirements for training and inference, which has long plagued edge intelligence applications.

Bacteria can deliver toxic effector proteins into the cytosol of neighboring cells. Here, the authors show that Yersinia pseudotuberculosis secretes an effector that modulates gene expression in neighboring cells of the same species and inhibits the growth of other competitors.

Multiplexed, brain-wide imaging remains challenging with current tissue clearing techniques. Here, the authors propose SOLID, a hydrophobic tissue clearing method that can minimize tissue distortion and attain great clearing performance. SOLID achieves high-quality imaging of multi-colour-labeled mouse brain.

Mechanisms underlying the connection between autophagy decline and vascular endothelial cell (VEC) ageing remain unclear. Here, the authors identify a key role for CD44 in controlling autophagy and ageing in VECs, and this function is conserved in nematodes.

The Arctic is dotted with lakes, including thermokarst lakes highly threatened by climate change. Here, the authors investigate 35 years of lake drainage events and related vegetation trends across the Arctic, finding differences between thermokarst and non-thermokarst lake drainage events.

Organoboron compounds are of high interest in organic synthesis due to the versatility of boryl substituents that allows access to further modifications. Here, the authors report on the development of an oxidative C(sp³)−H borylation reaction under metal- and oxidant-free conditions, enabled by photoelectrochemical strategy

The optical detection of two virulence factors of Mycobacterium tuberculosis on extracellular vesicles in blood allowed for the diagnosis of tuberculosis in paediatric cases that were missed by clinical microbiological assays.

The water-to-land transition of vertebrates is a landmark event in evolutionary history. This work utilizes single-cell RNA sequencing to explore the adaptations in African lungfish lungs and gills to terrestrialization.

This paper shows that the uniformity of vitreous ice thickness relies on the surface flatness of the supporting film, and presents a method to use ultraflat graphene as the support for cryo-EM specimen preparation.

Non-trivial topological phases come in various guises from first-order to higher-order and can be found in a range of systems from electronic and photonic through to phononic. Here, the authors report a variable-order topological insulator in a phononic crystal that can be tuned between first and higher orders by varying the nearest-neighbor hopping whilst at the same time preserving the symmetry.

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Cryomicroneedles (cryoMNs) permit the precise delivery of therapeutic cells into the skin, but are limited by the cold-chain transportation and storage. This article introduces an innovative solution to use a prefabricated porous microneedle scaffold that can be shipped at room temperature and allow on-site cell loading and usage in the clinic (i.e., the second generation cryoMNs or S-cryoMNs). The study investigates the loading and intradermal delivery of three cell types in clinically relevant in vitro and in vivo models, including mesenchymal stem cells for wound healing, melanocytes for vitiligo treatment, and antigen-pulsed dendritic cells for cancer vaccination.