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Single-cell transcriptomic and genomic changes in the ageing human brain

Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the expression of these genes.

Ailsa M. Jeffries
Tianxiong Yu
Michael A. Lodato
ResearchOpen Access03 Sept 2025
Nature

Volume: 646, P: 657-666
The degradation mechanism of multi-resonance thermally activated delayed fluorescence materials

The limited operational stability of multi-resonance thermally activated delayed fluorescence emitters often constrains their practical application. Here, the authors report a direct correlation between device lifetime and Faradaic yield for oxidative degradation of emitter molecules.

Byung Hak Jhun
Yerin Park
Youngmin You
ResearchOpen Access04 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Sub-unit-cell-segmented ferroelectricity in brownmillerite oxides by phonon decoupling

Scaling effects on ferroelectric domains could impact applications for next-generation miniaturized devices. Here brownmillerite oxides are shown to demonstrate ferroelectric domains with widths down to the sub-unit-cell level.

Jinhyuk Jang
Yeongrok Jin
Si-Young Choi
Research20 May 2025
Nature Materials

Volume: 24, P: 1228-1235
Chip collection of hepatocellular carcinoma based on O₂ heterogeneity from patient tissue

Hepatocellular carcinoma is the most common type of primary liver cancer. Here the authors show an oxygen gradient chip that separates aggressive hepatocellular carcinoma cells from a heterogeneous tumor mass, mirroring the conditions of the portal vein, hepatic artery, and liver.

Sewoom Baek
Hyun-Su Ha
Hak-Joon Sung
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

Jaewon Lee
Jihoon Ha
Seok Hee Park
ResearchOpen Access01 Jun 2023
Experimental & Molecular Medicine

Volume: 55, P: 1218-1231
A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells

Yerin Kim
Jun Kyu Park
Sang Won Kang
ResearchOpen Access08 Nov 2018
Scientific Reports

Volume: 8, P: 1-13
Flow-induced reprogramming of endothelial cells in atherosclerosis

In this Review, Jo and colleagues discuss blood flow-induced mechanisms involved in endothelial cell dysfunction and atherosclerosis, including the emerging concept of disturbed-flow-induced reprogramming of endothelial cells as a pro-atherogenic mechanism, and highlight the therapeutic potential of targeting of flow-sensitive genes, proteins and pathways.

Ian A. Tamargo
Kyung In Baek
Hanjoong Jo
Reviews24 May 2023
Nature Reviews Cardiology

Volume: 20, P: 738-753
Testing multiple hypotheses on the colour change of treefrogs in response to various external conditions

Chohee Park
Seongsoo No
Changku Kang
ResearchOpen Access14 Mar 2023
Scientific Reports

Volume: 13, P: 1-9
Microbial profiling of the East Siberian Sea sediments using 16S rRNA gene and metagenome sequencing

Jehyun Jeon
Yerin Park
Yung Mi Lee
ResearchOpen Access18 Dec 2024
Scientific Data

Volume: 11, P: 1-11

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Single-cell transcriptomic and genomic changes in the ageing human brain

The degradation mechanism of multi-resonance thermally activated delayed fluorescence materials

Sub-unit-cell-segmented ferroelectricity in brownmillerite oxides by phonon decoupling

Chip collection of hepatocellular carcinoma based on O₂ heterogeneity from patient tissue

Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells

Flow-induced reprogramming of endothelial cells in atherosclerosis

Testing multiple hypotheses on the colour change of treefrogs in response to various external conditions

Microbial profiling of the East Siberian Sea sediments using 16S rRNA gene and metagenome sequencing

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