Search

A pharmacophore-oriented 3D molecular generation method, which efficiently generates diverse, drug-like molecules is proposed. It successfully identifies new inhibitors in real-world drug discovery.

A survey across 90 societies reveals that variation and change in everyday norms are explained by a single value dimension: the priority societies place on individualizing versus binding moral concerns.

The development of exciplex-type hosts for thermally activated delayed fluorescence organic light-emitting diodes is hindered by a lack of structural information for these donor:acceptor blends. Here, the authors report the pump-probe Step-Scan Fourier transform IR spectra for a D:A exciplex host.

Here the authors report on exoelectrogenic bacteria-derived membrane fusion-liposome-coated titanium dioxide nanoparticles to mimic extracellular electron transfer to enhance superoxide anion production under low-dose X-ray irradiation for radiodynamic therapy.

Nanoplastics are a concern for health and safety. Here, the authors show polystyrene nanoplastics disrupt intestinal integrity and gut microbiota composition by altering microRNA expression in extracellular vesicles, highlight a potential pathway through which nanoplastic exposure affects gut health.

This study characterised the landscapes and changes of RNA m6A in brains of individuals with or without Alzheimer’s disease, and revealed roles of a promoter antisense RNA next to MAPT in neuronal gene regulation that promote neuronal survival.

Antimicrobial peptide mechanism of membrane disruption have not been fully characterized at the cellular level. Here, authors use cryo-electron tomography and AFM to directly visualize the disruption of the outer and inner membranes of Escherichia coli by a de novo-designed peptide.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The authors used massively parallel splicing assays and statistical learning to decode and predict the erroneous splicing choices made by disease-relevant mutant sequences, which annotates intronic variants potentially for clinical usage.

Existing organic long-persistent luminescence systems do not align with human scotopic vision. Here, authors achieve blue-shifted emissions in binary systems by upconverting charge-transfer to locally excited singlet state, with a strong luminescence under international standard for safety signs.

The authors develop a deep learning framework for 3D ligand pharmacophore mapping, enabling binding pose prediction, lead discovery, and target fishing. Using this approach, they identify structurally different inhibitors for human glutaminyl cyclases.

Direct conversion of solar energy to stored chemical energy can be achieved through photoisomerization. Here, authors exploit thermally activated delayed fluorescence materials as a photosensitizer and signal transducer to harness solar energy, to maximize solar spectrum harvesting without sacrificing energy storage time.

Li et al. developed a base-editing system to edit mutations linked to autism. Targeting a mutation in Mef2c restored Mef2c protein levels in several brain regions and reversed behavioral changes in Mef2c-mutant mice.

A common East Asian-specific defect of an alcohol metabolizing enzyme (ALDH2) causes glucose abnormality, obesity, and fatty liver. Here, the authors show an ALDH2 activator can treat these metabolic disorders in mice.

Unlike metabolic reprogramming that is characteristic of macrophage inflammatory polarization responses to lipopolysaccharide and TLR4 stimulation, the metabolism underlying inflammatory responses to CD40 signaling is not well characterized. Here the authors show CD40 signaling drives fatty acid oxidation and glutamine metabolism resulting in regulation of the NAD⁺/NADH ratio, which in turn promotes antitumor and pro-inflammatory macrophage functions.

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Measuring phosphorylation stoichiometry on a proteomic scale remains a challenge. Tsai et al. develop a technique to measure the basal level of phosphorylation stoichiometry in a single human phosphoproteome and identify molecular changes associated with gefitinib resistance in lung cancer cells.

Dusp6-deficient mice are resistant to diet-induced obesity. Transfer of the faecal microbiota from Dusp6-deficient mice increases energy expenditure and reduces weight gain of recipient germ-free wild-type mice fed a high-fat diet.

Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is shown to be of clinical prognostic relevance.

Callosal projection neurons located in the hemisphere contralateral to primary glioblastoma promote progression and widespread infiltration, and screening of axon guidance genes identified SEMA4F as a key regulator of tumourigenesis and activity-dependent progression.

Glioblastoma tumours expressing oncogenic PIK3CA variants secrete the glycan GPC3, which promotes the formation of neural synapses, brain synaptic hyperexcitability and gliomagenesis.

Hi-C 3.0 and ChIP-seq show that SARS-CoV-2 infection alters the host cell 3D genome structure and epigenome.

Electrochromism provides a means to control transmittance of light for increased energy efficiency of buildings. Here the aqueous electrochromic design features tunable emissivity and allows for all-season radiative thermoregulation.

An organoboron-emitter, DBTN-2, yields a green organic light-emitting diode with ultrapure colour and high efficiency.

Inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis.

The mechanism underlying screening of a Kondo lattice of magnetic moments by conduction electrons is an important unsolved problem. Figgins et al. use STM techniques to assemble nanoscale Kondo droplets that extrapolate between a single moment and the Kondo lattice, providing a platform for further study.

IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5⁺ stem cell expansion via Tcf4.

A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics is developed, reducing sample loss and processing time, allowing the phosphoproteome profiling of mass-limited samples at the low nanogram level.