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Commonly used opioids for pain management primarily target the mu opioid receptor. However, mu opioid receptor agonists often come with harmful side effects. Here, the authors report the results of two phase 3 trials of HSK21542 (anrikefon), a highly selective activator of peripheral kappa opioid receptor agonists, for postoperative pain treatment following abdominal surgery.

An in-built fluoropolyether-based quasi-solid-state polymer electrolyte enables high-capacity lithium-rich manganese-based layered oxide cathodes with stable interfaces, achieving 604 Wh kg⁻¹ pouch-cell energy density.

Polyol oxidation to dicarboxylic acids is hindered by conflicting needs for C–H activation and product desorption. This work resolves the issue using fully exposed Ptn clusters on hydroxyapatite, enabling efficient and selective catalysis.

Molecular electronics or spintronics relies on manipulating the electronic transport through microscopic molecule structures. Here the authors demonstrate the selective electron pathway in single-molecule device by magnetic field which enables a tunable anisotropic magnetoresistance up to 93%.

Radiosensitising agents can enhance radiotherapy and improve outcomes. Here, the authors report on the design of bioinspired Radiosensitising and biocatalytic nanoparticles to increase radiation tiggered cell death and immunogenic response to combat both primary and metastatic tumours.

A direct correlation between the monolayer Pt nanocluster size and the number of interfacial perimeters on Pt/α-MoC_1-x catalysts was established by combining sacrificial CO adsorption per Pt atom, DFT calculations, and CO chemisorption measurements.

CIGS is a high-resolution dataset comprising chemical perturbation-induced 319,045,108 gene expression events.

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

Here, the authors use multi-omic data to reveal how genetic and epigenetic variation affects gene expression in two pig breeds. The findings highlight strong tissue-specific regulation and identify genes with allele-specific expression.

Adenosine-to-inosine editing in SNHG3 (c.1746 A > I) drives non-small cell lung (NSCLC) cancer metastasis and docetaxel resistance by enhancing SSRP1 binding and altering fatty acid metabolism. Targeting this hyper-edited RNA may improve cancer therapy.

Using single-cell and spatial molecular profiling of infarcted mouse and human hearts, Li, Ni, Wang and colleagues identify a subset of cardiac fibroblasts expressing CD248 that plays a critical role in fibroblast–T cell interaction, and show that disrupting this interaction with monoclonal antibodies or anti-CD248 chimeric antigen receptor T cells results in reduced cardiac fibrosis and improved function.

Catalytic upcycling of polyethylene terephthalate (PET) into high-value oxygenated products is a fascinating process, yet it remains challenging. Here, the authors present a one-step tandem strategy to realize the thermal catalytic oxidation upcycling of PET to terephthalic acid and high-value glycolic acid.

The authors present a reference genome for Hordeum I-genome species. This work unravels genomic features that drive adaptation to salt and alkali environments and could aid in improving crop resilience.

This study uncovers key challenges in allele-aware genome scaffolding with Hi-C data. A reference-independent Hi-C scaffolder showing superior performance was developed to construct the haplotype-resolved genome of triploid Miscanthus × giganteus.

Natural proteins exhibit rich structural diversity based on the folds of an invariably linear chain. Here the authors design a single-domain GFP catenane as the counterpart of conventional linear GFP with enhanced thermal resilience and to provide a robust scaffold for making fusion protein catenanes.

A continuous-acquisition method for reducing artefacts caused by the beating heart and other body motions in cardiovascular magnetic resonance imaging reduces the reliance on electrocardiography triggering and breath holds.

A high-quality autopolyploid genome of Saccharum spontaneum accession Np-X and resequencing of 102 accessions provide insights into the recent chromosome reduction and polyploidization in Saccharum.

Despite being a promising treatment for hepatocellular carcinoma (HCC), resistance to tyrosine kinase inhibitors (TKI) present a major obstacle. Here, the authors demonstrate that lipid metabolism reprogramming via URI mediated stearoyl-CoA desaturase 1 upregulation present a targetable driver of sorafenib resistance in HCC.

Protein subunits on the capsids of icosahedral viruses can form patterns with rotational symmetry, which are difficult to recreate in the laboratory. Here the authors report a strategy to construct 3D chiral polyhedra with rotational faces from 2D chiral truxene-based units through dynamic covalent chemistry.

This work develops defective MnO2 catalysts with Frustrated Lewis Pairs through a coordination number reduction strategy to enhance the aerobic oxidation of various polyols/sugars to formic acid.

Macadamia is a recently domesticated nut crop. Here, the authors report the genome assembly of Hawaiian cultivar ‘Kau’ and conduct population genomic analyses to reveal the origin of Hawaiian cultivars and the genomic basis for one-step operation for the clonal crop domestication.

Gboxin, an inhibitor of oxidative phosphorylation (OXPHOS), can suppress the proliferation of glioblastoma (GBM) cells. Here the authors describe the design of a cancer cell-mitochondria hybrid membrane camouflaged reactive oxygen species (ROS)-responsive nanoparticle loaded with Gboxin, showing anti-tumor responses in GBM preclinical models.

Mosquito saliva affects transmission of flaviviruses, but underlying mechanisms are incompletely understood. Here, the authors show that Aedes aegypti venom allergen-1 (AaVA-1) promotes dengue and Zika virus transmission by activating autophagy in host immune cells of the monocyte lineage.

TRPV1 has been associated with proliferation and survival of tumors, and can be activated by heat and other stimuli. Here, the authors block TRPV1 using photothermal nanoparticles encapsulating a TRPV1 antagonist in different cancer types, which can enhance thermo-immunotherapy in pancreatic cancer models.

As solid tumours develop, cancer cells shed energetically expensive tissue-specific functions, enabling uncontrolled growth despite a limited ability to produce ATP.

In this paper, the authors show that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, identifying Acsl6 as a mitochondrial sex-biased regulator of diastolic function.

Viral diagnostics with maximum sensitivity are designed using machine learning and combinatorial optimization.

The gut membrane-associated protein Mesh controls proliferation of gut bacteria by regulating dual-oxidase expression through an arrestin-mediated MAPK JNK/ERK phosphorylation cascade in Aedes aegypti and Drosophila melanogaster.