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The authors find low-energy magnetic excitations and a flat band near the Fermi level in kagome metal superconductor CsCr3Sb5 by angle-resolved photoemission and resonant inelastic X-ray scattering. They suggest that the flat band plays a role in the emergence of charge/magnetic order at low temperatures.

TopoVelo infers cell differentiation stages and rate parameters of gene expression using spatially coupled differential equations.

Recovery from ischemic stroke involves dynamic interactions between immune cells and the brain. Here, the authors show that microglia reduction promotes long-term stroke recovery in mice by expanding reparative macrophages, enhancing vascular repair and white matter integrity.

The authors study the non-centrosymmetric achiral material In_xTaS₂ by angle-resolved photoemission spectroscopy and quantum oscillations. They find that it hosts an “ideal” Kramers nodal line, well isolated at the Fermi level.

By utilizing an AI-accelerated silicon photonic slow-light technology, researchers demonstrate a record 400 Gbps/λ PAM-4 transmission based on pure silicon modulators, paving the way for next-generation optical interconnects in computing centers.

Here, the authors have captured the intermediate states of the human spliceosome during its activation through cryo-EM reconstruction of six distinct spliceosomal complexes.

This study reveals the transition of move and evolve strategies and their interaction with niche opportunity and trait innovation throughout the diversification of the grape family—a globally distributed plant group originated in the Cretaceous.

Developed on cytology images of hydrothorax and ascites from 57,220 cases at four hospitals, a deep-learning model shows high accuracy in tumor origin prediction and presents prognostic value when patient treatment is consistent with the cancer origin predicted by the model.

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

A large-scale photonic accelerator comprising more than 16,000 components integrated on a single chip to process MAC operations is described, demonstrating ultralow latency and reduced computing time compared with a commercially available GPU.

Flood exposure can increase the risk of intimate partner violence. Intra-household and societal gender inequalities can further exacerbate this vulnerability.

Single-crystal black phosphorus nanoribbons are grown uniformly on insulating substrates by chemical vapour transport growth with black phosphorus nanoparticles as seeds, demonstrating potential for application in nanoelectronic devices and the exploration of the exotic physics in black phosphorus.

scNanoHi-C combines Nanopore long-read sequencing with a proximity-ligation-based Hi-C protocol to profile high-order genome structures in individual cells, enabling the capture of multiway interactions among enhancers and promoters.

Ancient DNA, stable isotopes and other archaeological methods establish that humans were living at extremely high elevation on the Tibetan Plateau 4,400 years ago, maintaining sedentary lifestyles that combined fishing, hunting and crop exchange.

Reaching the depths of the respiratory tract is hard even with vapor-based drug delivery. Here, the authors devise inhalable biohybrid microrobots that, thanks to their motility, reach deeper regions of the lungs.

Studying the cell composition of acral melanoma at the single-cell level could provide some clues about its poor response to immunotherapy. Here, the authors analyse acral and cutaneous melanoma patient samples using single-cell RNA-sequencing, and reveal a severe immunosuppressive state in acral melanomas

A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.

Green spaces are known to help cool cities, but they contribute humidity while reducing heat—and both matter. Using smart sensors mounted on bicycles, this study finds that daytime temperature reductions in urban green spaces are largely offset by humidity increases but that urban vegetation causes a net reduction in humid heat at night.

The chaperone Hsp27 prevents FUS from undergoing liquid–liquid phase separation until stress-induced phosphorylation causes Hsp27 to partition with FUS to preserve the liquid phase against amyloid fibril formation.

Neuronal organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes and two photon imaging for longitudinal, multimodal monitoring of functional connectivity between human iPSC derived neuronal organoids and the mouse cortex.

Here, the authors structurally characterize two sequential complexes leading to prespliceosome assembly, providing insights into the mechanism of branch site proofreading in the human spliceosome.

Optical imaging and manipulation technologies cannot be easily integrated with electrical recordings due to generation of light-induced artifacts. Here the authors report the optimization of transparent graphene microelectrode fabrication to achieve artifact-free electrical recordings along with deep 2-photon imaging in vivo.

An analysis of subsoil structure using lunar regolith penetrating radar at the Chang’E-6 landing site indicates a distinct 2-layer structure, and when compared with Apollo mission data, suggests a link between regolith maturity and electromagnetic properties.

Polo-like kinase 3 (Plk3) has a tumor suppressive role through the induction of apoptosis, however, the mechanism underlying its activation is unclear. Here, in pancreatic cancer, the authors show that activation of Plk3 is dependent on its cleavage into p41Plk3, by the metalloendopeptidase nardilysin.

Here, Zhouyan et al. present the structure of yeast SIN3–HDAC complex Rpd3L, revealing a distinctive organization mechanism compared with other class I HDAC complexes. The authors observe that two distinct arms hang on a T-shaped scaffold formed by two coiled-coil domains.

Observations of strong electron correlation effects have been mostly confined to compounds containing f orbital electrons. Now, the study of the 3d pyrochlore metal CuV₂S₄ reveals that similar effects can be induced by flat-band engineering.

The tunability of electronic properties is a central goal of research into topological semimetals. Here, the authors report Weyl nodal ring states in the magnetic semimetal EuGa₄ and link the nodal ring state to the observed large non-saturating magnetoresistance.

Tocilizumab has been used to treat the excessive inflammatory responses in COVID-19 patients. Here, the authors use single-cell RNA sequencing results from two severe COIVD-19 patients to provide high-dimensional immune profiling data, and to implicate potential cellular and molecular insights for the therapeutic effects of tocilizumab.

Understanding loss mechanisms in superconducting circuits is crucial for improving qubit coherence. Here the authors use a multimode resonator to study loss mechanisms in thin-film superconducting circuits and demonstrate on-chip quantum memories with lifetimes exceeding 1ms, using Ta thin-films and high-temperature substrate annealing

Multi-omic analysis of 100 clear cell renal cell carcinomas identifies four transcriptomic subgroups (IM1–IM4). IM4 is a high-risk subtype characterized by specific metabolic changes and a loss of lipid droplets.

Pseudouridine (Ψ) is an important modification in RNA biology and mRNA vaccine. A method called PRAISE was developed via selective labeling of Ψ by bisulfite to induce nucleotide deletion signature during reverse transcription, thus realizing quantitative assessment of the Ψ landscape in the human transcriptome.

A quantum key distribution with a key rate of 115.8 Mb s^–1 is demonstrated over 10 km standard optical fibre. To this end, a high-speed and stable system, an integrated transmitter for low error modulation and multipixel superconducting nanowire single-photon detectors are developed.

The stacked and brittle 2D layered structure of molybdenum disulphide limits its practical application in lithium ion batteries. Here, authors report a dewetting-induced manufacture strategy to create the interpenetrating network and induce the pseudocapacity to improve the electrochemical performance.

Liu et al. present a flexible, insertable and transparent microelectrode (FITM) array termed Neuro-FITM. Multimodal recordings with Neuro-FITM reveal diverse and selective large-scale cortical activation patterns associated with hippocampal sharp-wave ripples.

Energy- and area-efficient vanadium-dioxide-based Mott activation neuron devices enable the implementation of activation functions in neural networks.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Vegetation productivity in the Northern Hemisphere has increased under climate change since the 1980s. However, the correlations between productivity and summer temperature are projected to decrease by the end of the century, with implications for the magnitude of the terrestrial carbon sink.

A large-scale genetic study conducted on European and Asian populations reveals shared genetic variants associated with the most severe form of spermatogenic failure, offering valuable insights into the underlying mechanisms of male infertility.