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Showing 1–50 of 65 results

Advanced filters: Author: Yinan Yang Clear advanced filters

An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA for degradation and reducing protein levels in the brain of humanized MECP2-transgenic mice and nonhuman primates.

Dong Yang
Xiaoqing Wu
Hui Yang
Research12 Dec 2024
Nature Neuroscience

Volume: 28, P: 72-83
Stable zinc anode solid electrolyte interphase via inner Helmholtz plane engineering

Here, the authors report that introducing βcyclodextrins (CD) as anion-receptors into Zn(OTf)2 aqueous electrolyte could significantly optimize the Zn anode SEI structure for achieving stable ZIB.

Jinrong Luo
Liang Xu
Jin Zhang
ResearchOpen Access31 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Oncolytic virus VG161 in refractory hepatocellular carcinoma

Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.

Yinan Shen
Xueli Bai
Tingbo Liang
Research19 Mar 2025
Nature

Volume: 641, P: 503-511
Magnetotransport evidence for the coexistence of two-dimensional superconductivity and ferromagnetism at (111)-oriented a-CaZrO₃/KTaO₃ interfaces

The authors report magnetotransport evidence for the coexistence of a two-dimensional (2D) superconducting state and a 2D ferromagnetic state at the interface between amorphous CaZrO₃ film and KTaO₃ single crystal. Moreover, the magnetoresistance hysteresis reaches a maximum near the superconducting transition temperature.

Hui Zhang
Yinan Xiao
Jinsong Zhang
ResearchOpen Access28 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV

SFTS is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse models.

Chen Xing
Cong Zhang
Yan Liu
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma

Yinan Shen
Xueli Bai
Tingbo Liang
Amendments and Corrections23 Apr 2025
Nature

Volume: 641, P: E5
Extensive germline genome engineering in pigs

Pigs can be genetically modified to inactivate endogenous retroviruses and to display enhanced compatibility with the human immune system using a combination of CRISPR–Cas9 and transposon technologies.

Yanan Yue
Weihong Xu
Luhan Yang
Research21 Sept 2020
Nature Biomedical Engineering

Volume: 5, P: 134-143
A serine/threonine protein kinase encoding gene KERNEL NUMBER PER ROW6 regulates maize grain yield

Selection of kernel number per ear has improved maize yield, but the genetic base is unclear. Here, the authors reveal that a serine/threonine protein kinase KNR6 is a positive regulator of the trait and show in vitro evidences that KNR6 may function through phosphorylating an Arf GTPase-activating protein.

Haitao Jia
Manfei Li
Zuxin Zhang
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-11
Spatiotemporally resolved transcriptomics reveals the cellular dynamics of human retinal development

The cellular organization of retinal development is biologically complex. Here, the authors use spatial transcriptomics to analyse developing human retina providing insights into spatiotemporal expression signatures and cellular communication during retinogenesis

Jinglong Zhang
Jiao Wang
Xing-Ming Zhao
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-15
Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

The evolutionally conserved Hippo pathway regulates essential developmental, homeostatic and regenerative processes, and is involved in the host defense against pathogens. Here authors show that in Drosophila Melanogaster and mammalian cells, innate immune stimuli activate Hippo via a pathway emanating from the Tak1 kinase and cascading down to Hippo via STRIPAK-Tao-Hpo signaling.

Yinan Yang
Huijing Zhou
Bo Liu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Correction: Corrigendum: Engineering and optimising deaminase fusions for genome editing

Luhan Yang
Adrian W. Briggs
George Church
Amendments and CorrectionsOpen Access09 Oct 2017
Nature Communications

Volume: 8, P: 1
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

Miniature gene editing tools are highly desired for efficient in vivo delivery and disease treatment. Here, the authors reported engineering hypercompact TnpB-ωRNA for robust gene editing with minimal off-target effect in cultured cells and use it to rescue fatal genetic liver disease in a tyrosinaemia mouse model.

Zhifang Li
Ruochen Guo
Chunlong Xu
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-11
An ethylene biosynthesis enzyme controls quantitative variation in maize ear length and kernel yield

Considerable genetic variation exists in maize ear size and kernel number. Here the authors show that variation in a gene encoding an ethylene biosynthetic enzyme impacts ear length, flower fertility and kernel yield suggesting an important role for ethylene signaling during inflorescence development.

Qiang Ning
Yinan Jian
Zuxin Zhang
ResearchOpen Access05 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Fire activity as measured by burned area reveals weak effects of ENSO in China

Víctor Resco de Dios
Yinan Yao
Matthias M. Boer
ResearchOpen Access28 Jul 2022
Nature Communications

Volume: 13, P: 1-4
Area of Habitat maps for national key protected wildlife in China

Yinan Yang
Yixuan Yang
Yujing Xie
ResearchOpen Access07 Jul 2025
Scientific Data

Volume: 12, P: 1-7
Engineering and optimising deaminase fusions for genome editing

Precision genome engineering using homology donors and the endogenous DNA break repair machinery and recently CRISPR-Cas9 targeted APOBECs have been demonstrated. Here the authors design zinc-finger and TALE chimeric deaminases and investigate editing efficiency and off-target effects.

Luhan Yang
Adrian W. Briggs
George Church
ResearchOpen Access02 Nov 2016
Nature Communications

Volume: 7, P: 1-12
Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants

Individual antibodies identified in the blood of people triple-vaccinated against SARS-CoV-2 predominantly bind spike protein and are highly effective at neutralizing SARS-CoV-2 variants, including Omicron (B.1.1.529).

Kang Wang
Zijing Jia
Xiangxi Wang
ResearchOpen Access28 Jan 2022
Nature

Volume: 603, P: 919-925
Infrared nano-imaging of Dirac magnetoexcitons in graphene

Dirac magnetoexcitons with non-trivial nanoscale electrodynamics are formed from the excitation of Landau levels in charge-neutral graphene. Here, the Dirac magnetoexciton dispersion is directly imaged up to 7 T via a magneto cryogenic near-field microscope.

Michael Dapolito
Makoto Tsuneto
Mengkun Liu
Research21 Aug 2023
Nature Nanotechnology

Volume: 18, P: 1409-1415
The potential of seep carbonates to preserve the seawater isotope compositions

Aragonite-dominated seep carbonates are a promising archive for understanding past seawater chemistry changes, according to an isotopic analysis of a core from the South China Sea.

Yinan Deng
Qingjun Guo
Mingyu Zhao
ResearchOpen Access23 May 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

Yusheng Cheng
Hui Li
Yang Yang
ResearchOpen Access19 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-11
Timing of spermarche and menarche among urban students in Guangzhou, China: trends from 2005 to 2012 and association with Obesity

Yusheng Deng
Jianping Liang
Li Liu
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

Improved glycemic control after transplantation of human pluripotent stem-cell-derived islets for diabetes treatment in non-human primates.

Yuanyuan Du
Zhen Liang
Hongkui Deng
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 272-282
Photon-trapping microstructures enable high-speed high-efficiency silicon photodiodes

Light-trapping nanoscale holes are exploited to improve the speed and efficiency of silicon photodiodes with intrinsic layers less than 2 μm thick.

Yang Gao
Hilal Cansizoglu
M. Saif Islam
Research03 Apr 2017
Nature Photonics

Volume: 11, P: 301-308
Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

Yinan Deng
Yingcai Zhang
Yang Yang
ResearchOpen Access05 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Wafer-scale production of patterned transition metal ditelluride layers for two-dimensional metal–semiconductor contacts at the Schottky–Mott limit

Two-dimensional metallic WTe₂ and MoTe₂ layers can be combined with a semiconducting MoS₂ monolayer to create metal–semiconductor junctions that are free from substantial disorder effects and Fermi-level pinning.

Seunguk Song
Yeoseon Sim
Soon-Yong Kwon
Research06 Apr 2020
Nature Electronics

Volume: 3, P: 207-215
Human-Pathogenic Enterocytozoon bieneusi in Captive Giant Pandas (Ailuropoda melanoleuca) in China

Wei Li
Zhijun Zhong
Guangneng Peng
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-7
Tomato SlAN11 regulates flavonoid biosynthesis and seed dormancy by interaction with bHLH proteins but not with MYB proteins

Yongfeng Gao
Jikai Liu
Yinan Yao
ResearchOpen Access01 Jun 2018
Horticulture Research

Volume: 5, P: 1-18
Whole-animal functional and developmental imaging with isotropic spatial resolution

IsoView microscopy achieves rapid isotropic-resolution imaging of large, nontransparent samples using simultaneous light-sheet illumination and fluorescence detection in four orthogonal directions.

Raghav K Chhetri
Fernando Amat
Philipp J Keller
Research26 Oct 2015
Nature Methods

Volume: 12, P: 1171-1178
Predictive and clinicopathological importance of HMGB2 in various carcinomas: a meta and bioinformatic approach

Yinan Zhu
Siyu He
Xuyong Lin
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network

Haiyang Yu
Shangbin Yang
Biqin Lai
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages

Xiaohong Zheng
Siyuan Tian
Ying Han
ResearchOpen Access07 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-16
Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

Wenkui Dai
Hui Du
Ruifang Wu
ResearchOpen Access20 Mar 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-5
Self-assembled ultraflexible probes for long-term neural recordings and neuromodulation

The authors describe the fabrication, assembly and long-term implantation of ultraflexible neural probes for the simultaneous recording of neural activity and neuromodulation in rodents.

Shouliang Guan
Huihui Tian
Ying Fang
Protocols29 May 2023
Nature Protocols

Volume: 18, P: 1712-1744
SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN

Zixuan Wang
Xiaolong Qiao
Chuandong Cheng
ResearchOpen Access13 Aug 2024
Cell Death Discovery

Volume: 10, P: 1-12
Derivation of totipotent-like stem cells with blastocyst-like structure forming potential

Yaxing Xu
Jingru Zhao
Hongkui Deng
ResearchOpen Access04 May 2022
Cell Research

Volume: 32, P: 513-529
PDIA2 has a dual function in promoting androgen deprivation therapy induced venous thrombosis events and castrate resistant prostate cancer progression

Yinan Li
Lei Lv
Lan Zhang
Research08 Apr 2024
Oncogene

Volume: 43, P: 1631-1643
Association of Crohn’s disease and ulcerative colitis with the risk of neurological diseases: a large-scale Mendelian randomization study

Yinan Wang
Yiming Jia
Zhengbao Zhu
Research01 Jul 2024
Journal of Human Genetics

Volume: 69, P: 565-571
Numerical modeling the process of deep slab dehydration and magmatism

Hao Wu
Jiacheng Lei
Jian Wang
ResearchOpen Access04 Nov 2024
Scientific Reports

Volume: 14, P: 1-17
Kawasaki disease coronary artery lesions prediction with monocyte-to-high-density lipoprotein ratio

Chao Yang
Yinan Yang
Xiaobin Hu
Research29 Nov 2022
Pediatric Research

Volume: 94, P: 246-251
Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer

Kaixin Yang
Wenyang Zhang
Lei Shi
ResearchOpen Access11 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1533-1549
Secular trends in overweight and obesity among urban children and adolescents, 2003–2012: A serial cross-sectional study in Guangzhou, China

Yinan Zong
Runsheng Xie
Yi Yang
ResearchOpen Access21 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest

Ruina He
Jingyu Peng
Wensheng Wei
ResearchOpen Access05 Sept 2017
Scientific Reports

Volume: 7, P: 1-14
Coordinated regulation of protein synthesis and degradation by mTORC1

mTORC1 is known to stimulate protein synthesis; now, it is shown to also promote the synthesis of proteasomes, which degrade proteins into the amino acids needed to create new proteins.

Yinan Zhang
Justin Nicholatos
Brendan D. Manning
Research13 Jul 2014
Nature

Volume: 513, P: 440-443
OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR

OTUD6A, a deubiquitinase, is amplified in prostate cancer and correlates with poor survivability, increasing the growth of prostate cancer cell lines and PDX models. OTUD6A stabilizes the expression of Brg1 and AR through the removal of K27- and K11-linked polyubiquination.

Xuhong Fu
Junjie Zhao
Liyu Huang
ResearchOpen Access01 Mar 2022
Communications Biology

Volume: 5, P: 1-13
Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Gang Ma
Jiaqi Yang
Jingbo Wang
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-10
Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications

Yinan Xiao
Yaru Ren
Lei Shi
ReviewsOpen Access23 Oct 2024
Cell Death Discovery

Volume: 10, P: 1-15
The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity

Jinhua Lu
Boon King Teh
Kenneth B M Reid
Reviews01 Feb 2008
Cellular & Molecular Immunology

Volume: 5, P: 9-21
Study on detonation characteristics of pulverized coal and evolution law of detonation residue

Jing Guo
Shirong Ge
Ruibo Yang
ResearchOpen Access22 May 2024
Scientific Reports

Volume: 14, P: 1-18
Comparative Genomics Analysis in Grass Species Reveals Two Distinct Evolutionary Strategies Adopted by R Genes

Yinan Zhang
Meijun Guo
Pingyi Guo
ResearchOpen Access24 Jul 2019
Scientific Reports

Volume: 9, P: 1-10
Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas

Mengwei Li
Xu Ding
Hanmei Xu
ResearchOpen Access13 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-12

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