Nature Search

Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial

In a multicenter, open-label, randomized phase 2 trial, neoadjuvant chemoradiation with PD-1 blockade elicited a pathological complete response rate superior to that with neoadjuvant chemoradiation alone in patients with locally advanced rectal cancer.

Yingchi Yang
Kai Pang
Zhongtao Zhang
Research06 Jan 2025
Nature Medicine

Volume: 31, P: 449-456
Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Tumour relapse after resection undermines the efficacy of surgical treatment for glioblastoma multiforme. Here the authors present a hydrogel that can be injected in the tumour cavity after resection and that promotes antitumour immunity, reducing postoperative cancer growth in animal models.

Jing Zhang
Chen Chen
Xinyi Jiang
Research01 Feb 2021
Nature Nanotechnology

Volume: 16, P: 538-548
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential

Sainan Li
Yingchao Liu
Yanchun Li
ReviewsOpen Access02 Sept 2025
Cell Death Discovery

Volume: 11, P: 1-14
Explore the role of CBS in stomach adenocarcinoma based on the sulfur-containing amino acid metabolism network

Ping Zhang
Yingchao Liu
Jun Xia
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-18
The role of comfort, personality, and intention in smartwatch usage during sleep

Hongting Li
Bingfei Xu
Liang Xu
ResearchOpen Access30 May 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-11
Proteomics-driven noninvasive screening of circulating serum protein panels for the early diagnosis of hepatocellular carcinoma

Hepatocellular carcinoma is often diagnosed at a late stage which limits treatment efficacy. Here, the authors utilise proteomics to identify serum proteomic biomarkers for early diagnosis, and validate using a prospective validation cohort.

Xiaohua Xing
Linsheng Cai
Xiaolong Liu
ResearchOpen Access18 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Uncovering pleiotropic loci in allergic rhinitis and leukocyte traits through multi-trait GWAS

Liulin Yang
Bichen Peng
Lei Shao
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Self-optimizing, highly surface-active layered metal dichalcogenide catalysts for hydrogen evolution

Metal dichalcogenides are promising electrocatalysts for hydrogen evolution, but more active and stable materials are desired. Here the authors demonstrate that H-TaS₂ and H-NbS₂ possess high basal-plane activity that increases with cycling through changes in the morphology of the catalysts.

Yuanyue Liu
Jingjie Wu
Boris I. Yakobson
Research31 Jul 2017
Nature Energy

Volume: 2, P: 1-7
Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development

Human cerebellar development is fundamentally linked to its function. Here, the authors combine single-cell transcriptomics, spatial transcriptomics, and single-cell chromatin accessibility states to systematically depict an integrative spatiotemporal landscape of human fetal cerebellar development.

Suijuan Zhong
Mengdi Wang
Qian Wu
ResearchOpen Access22 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Epidemiology, evolution and transmission of human metapneumovirus in Guangzhou China, 2013–2017

Lina Yi
Lirong Zou
Jie Wu
ResearchOpen Access01 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Unraveling the formation mechanism of graphitic nitrogen-doping in thermally treated graphene with ammonia

Xiao-Fei Li
Ke-Yan Lian
Yi Luo
ResearchOpen Access22 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2

Qi Dong
Haoyuan Fu
Zhiyong Hou
ResearchOpen Access30 Jan 2025
Bone Research

Volume: 13, P: 1-16
Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment

Xinyi Yang
Yingchao Liu
Jing Du
ReviewsOpen Access21 Apr 2025
Cell Death Discovery

Volume: 11, P: 1-16
Development of a CT radiomics model for detection of bladder invasion by colorectal carcinoma

Jingui Wang
Kexin Wang
Xin Wang
ResearchOpen Access02 May 2025
Scientific Reports

Volume: 15, P: 1-11
Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR⁺/HER2-low breast cancer cell line ZR-75-1 via hsa-miR-23a-5p

Liushan Chen
Lingling Ye
Qianjun Chen
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-16
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer

Ping’an Ding
Haotian Wu
Qun Zhao
Research17 Jul 2024
Oncogene

Volume: 43, P: 2548-2563
High-throughput injection–acceleration of electron bunches from a linear accelerator to a laser wakefield accelerator

Previously, injections from a conventional accelerator into a plasma-based one suffered from low coupling efficiencies. Now electron bunches are injected with an efficiency of nearly 100% into a laser wakefield accelerator without loss of charge.

Yipeng Wu
Jianfei Hua
Chan Joshi
Research18 Mar 2021
Nature Physics

Volume: 17, P: 801-806
Decoding the spatiotemporal regulation of transcription factors during human spinal cord development

Yingchao Shi
Luwei Huang
Qian Wu
ResearchOpen Access05 Jan 2024
Cell Research

Volume: 34, P: 193-213
MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53

Yingchao Wang
Gaoxiong Wang
Jingfeng Liu
ResearchOpen Access15 Nov 2019
Oncogenesis

Volume: 8, P: 1-11
Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation

Xinhua Li
Xuejun Wang
Lijun Li
ResearchOpen Access07 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring

Yingchao Shi
Shihua Li
Xiaoqun Wang
ResearchOpen Access23 Feb 2018
Scientific Reports

Volume: 8, P: 1-14
Crosstalk between KIF1C and PRKAR1A in left atrial myxoma

Six variations of KIF1C that lead to decreased expression levels are identified in patients with left atrial myxoma (LAM). Inhibition of KIF1C promote LAM pathogenesis through a positive feedback formed by the crosstalk between KIF1C and PRKAR1A.

Mengchen Zhou
Yan Yao
Xin Tu
ResearchOpen Access14 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Correction: Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

Zengjie Zhang
Tianzhen Xu
Xiangyang Wang
Amendments and CorrectionsOpen Access07 Oct 2021
Cell Death & Disease

Volume: 12, P: 1
Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2

Arabidopsis H3K9 methyltransferases directly interact with ASYMMETRIC LEAVES1 (AS1) and AS2 to repress KNOTTED-LIKE FROM ARABIDOPSIS THALIANA 1 (KNAT1) and KNAT2 in leaf development.

Fu-Yu Hung
Yun-Ru Feng
Keqiang Wu
ResearchOpen Access24 Feb 2023
Communications Biology

Volume: 6, P: 1-13
Appropriate time to radical surgery for colorectal cancer patients complicated with newly onset cerebral infarction: a propensity score matching analysis

Weidong Dou
Tao Liu
Xin Wang
ResearchOpen Access23 Mar 2023
Scientific Reports

Volume: 13, P: 1-10
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma

Schwannoma cells are injected into the CPA region of the mouse brain to establish a model of vestibular schwannoma. Procedures for intravital imaging and neurological tests for hearing are also described.

Jie Chen
Lukas D. Landegger
Lei Xu
Protocols07 Jan 2019
Nature Protocols

Volume: 14, P: 541-555
Poly (dopamine) coated superparamagnetic iron oxide nanocluster for noninvasive labeling, tracking and targeted delivery of adipose tissue-derived stem cells

Naishun Liao
Ming Wu
Jingfeng Liu
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-13
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription

Xiaohua Jie
William Pat Fong
Shuangbing Xu
ResearchOpen Access08 Feb 2021
Cell Death & Differentiation

Volume: 28, P: 2095-2111
Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation

Fan Yang
Rongrong Wu
Jian’an Wang
ResearchOpen Access10 May 2018
Cell Death & Disease

Volume: 9, P: 1-17
Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

Zengjie Zhang
Tianzhen Xu
Xiangyang Wang
ResearchOpen Access24 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-16
Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells

Guohua Li
Yu Gan
Hong Tu
ResearchOpen Access19 Jan 2015
Scientific Reports

Volume: 5, P: 1-9
SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction

Xianbao Liu
Dexing Hu
Jian'an Wang
ResearchOpen Access06 Apr 2017
Cell Death & Disease

Volume: 8, P: e2731

Search

Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential

Explore the role of CBS in stomach adenocarcinoma based on the sulfur-containing amino acid metabolism network

The role of comfort, personality, and intention in smartwatch usage during sleep

Proteomics-driven noninvasive screening of circulating serum protein panels for the early diagnosis of hepatocellular carcinoma

Uncovering pleiotropic loci in allergic rhinitis and leukocyte traits through multi-trait GWAS

Self-optimizing, highly surface-active layered metal dichalcogenide catalysts for hydrogen evolution

Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development

Epidemiology, evolution and transmission of human metapneumovirus in Guangzhou China, 2013–2017

Unraveling the formation mechanism of graphitic nitrogen-doping in thermally treated graphene with ammonia

Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2

Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment

Development of a CT radiomics model for detection of bladder invasion by colorectal carcinoma

Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR⁺/HER2-low breast cancer cell line ZR-75-1 via hsa-miR-23a-5p

N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer

High-throughput injection–acceleration of electron bunches from a linear accelerator to a laser wakefield accelerator

Decoding the spatiotemporal regulation of transcription factors during human spinal cord development

MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53

Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation

Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring

Crosstalk between KIF1C and PRKAR1A in left atrial myxoma

Correction: Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2

Appropriate time to radical surgery for colorectal cancer patients complicated with newly onset cerebral infarction: a propensity score matching analysis

A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma

Poly (dopamine) coated superparamagnetic iron oxide nanocluster for noninvasive labeling, tracking and targeted delivery of adipose tissue-derived stem cells

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription

Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells

SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction

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