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Showing 1–50 of 53 results

Advanced filters: Author: Yingying Shao Clear advanced filters

High-throughput profiling of chemical-induced gene expression across 93,644 perturbations

CIGS is a high-resolution dataset comprising chemical perturbation-induced 319,045,108 gene expression events.

Lei Xiang
Yumei Wang
Dong Wang
Research18 Aug 2025
Nature Methods

Volume: 22, P: 1954-1963
Néel-type skyrmion in WTe₂/Fe₃GeTe₂ van der Waals heterostructure

Strong magnetic interfacial coupling in van der Waals heterostructures provides a new platform for discovering novel physics and effects. Here, the authors report the formation of skyrmion lattice in the WTe₂/Fe₃GeTe₂ van der Waals heterostructure and a Dzyaloshinskii–Moriya interaction with a large energy density of 1.0 mJm⁻².

Yingying Wu
Senfu Zhang
Kang L. Wang
ResearchOpen Access31 Jul 2020
Nature Communications

Volume: 11, P: 1-6
Exploring the use of large language models for classification, clinical interpretation, and treatment recommendation in breast tumor patient records

Beibei Miao
Qian Sun
Rongbiao Ying
ResearchOpen Access26 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Developmental innovation of inferior ovaries and flower sex orchestrated by KNOX1 in cucurbits

This research highlights the role of a KNOX1 transcription factor in stalling receptacle growth in cucumber, leading to bisexual flowers with superior ovaries like those in tomatoes. These insights enhance our understanding of ovary formation and sex in cucurbits.

Zhaonian Dong
Xiaolin Liu
Xueyong Yang
Research01 Apr 2025
Nature Plants

Volume: 11, P: 861-877
Infection of post-harvest peaches by Monilinia fructicola accelerates sucrose decomposition and stimulates the Embden–Meyerhof–Parnas pathway

Jingyu Kou
Yingying Wei
Xingfeng Shao
ResearchOpen Access01 Sept 2018
Horticulture Research

Volume: 5, P: 1-9
Acetylation is required for full activation of the NLRP3 inflammasome

The NLRP3 inflammasome is activated in two steps, priming and assembly, in response to endogenous, microbial, and other environmental danger signals. Here authors show that the assembly step is regulated by acetylation, and inhibition of this post-translational modification prevents full activation of the inflammasome.

Yening Zhang
Ling Luo
Kai Zhao
ResearchOpen Access18 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses

Chengyu Shi
Ying Wang
Aifu Lin
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis

Limin Xing
Manjun Zhao
Zonghong Shao
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
Van Hove annihilation and nematic instability on a kagome lattice

Scanning tunnelling microscopy and scanning tunnelling spectroscopy have been used to observe intra-unit-cell nematic order and associated Fermi surface deformation in ScV₆Sn₆.

Yu-Xiao Jiang
Sen Shao
M. Zahid Hasan
Research15 Jul 2024
Nature Materials

Volume: 23, P: 1214-1221
A sophisticated mechanism governs Pol ζ activity in response to replication stress

DNA polymerase ζ (Pol ζ) maintains continuity but impairs accuracy during DNA replication. Here, the authors report a mechanism by which human cells precisely control the essential, yet mutagenic, activity of Pol ζ to ensure both continuation and fidelity during DNA replication challenges.

Chun Li
Shuchen Fan
Xialu Li
ResearchOpen Access31 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction

Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.

Yuan Lin
Yingying Luo
Dongxin Lin
ResearchOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Chengyu Shi
Ying Wang
Aifu Lin
Amendments and CorrectionsOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-4
Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution

Lymphocyte subsets remain inadequately understood in jawless vertebrates, relative to jawed vertebrates. In this study, the authors combine single-cell RNA and whole-transcriptome sequencing to demonstrate that the lamprey, Lampreta morii, harbours specialised T-like cells that are distinct from those found in jawed vertebrates.

Yingyi Huang
Xiang Liu
Changwei Shao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes

Both cartilaginous and bony fishes have adaptive immune cells, but the evolutionary features of these diverse cell populations remain understudied. Here the authors report single-cell RNA sequencing atlas of both species to define these features and to find reduced evolutionary diversification of immune cells in cartilaginous fishes.

Hong-Yan Wang
Jian-Yang Chen
Changwei Shao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immunosuppressive microenvironments.

Xiannian Zhang
Linna Peng
Dongxin Lin
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake.

Jiang Chang
Wenle Tan
Dongxin Lin
ResearchOpen Access26 May 2017
Nature Communications

Volume: 8, P: 1-11
Ligand recognition and biased agonism of the D1 dopamine receptor

D1 dopamine receptor is an important drug target for treatment of hypertension and Parkinson’s disease. Here, authors report three cryo-EM structures of the D1R-Gs complex bound to three distinct D1R-selective drugs.

Xiao Teng
Sijia Chen
Sanduo Zheng
ResearchOpen Access08 Jun 2022
Nature Communications

Volume: 13, P: 1-11
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins

Chen et al. report that the YTHDF family of m⁶A-RNA-binding proteins can be differentially regulated by the post-translational modification O-GlcNAcylation, leading to differential regulation of the YTHDF proteins on translation and phase separation.

Yulin Chen
Ruixi Wan
Shixian Lin
Research09 Nov 2023
Nature Cell Biology

Volume: 25, P: 1676-1690
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

IL-17 mediated inflammation in the lung is mediated by different effector molecules. Here the authors show that the epigenetic regulator epithelial sirtuin 6 (Sirt6) is associated with lung inflammation in asthma patients and that Sirt6 contributes to promotion of inflammation in mouse asthma models.

Jingyun Quan
Xiaoxia Wen
Tianwen Lai
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-14
College students’ entrepreneurship policy, regional entrepreneurship spirit, and entrepreneurial decision-making

Yangjie Huang
Jiali Zhang
Yingying Chen
ResearchOpen Access11 Jun 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking

The molecular mechanisms underlying the regulation of dopamine transporter activity in the brain remain poorly understood. The authors show that glial cell line–derived neurotrophic factor, its receptor Ret and the Rho family GEF protein Vav2 are required for modulating dopamine transporter cell surface expression and transporter activity in the nucleus accumbens.

Shuyong Zhu
Chengjiang Zhao
Jiawei Zhou
Research06 Jul 2015
Nature Neuroscience

Volume: 18, P: 1084-1093
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

Despite lung adenocarcinoma having a high global mortality, the genetic mutations present in Asian patients are uncharacterized. Here the authors use genomic and transcriptomic analysis to identify thirteen significantly affected genes, including RHPN2, GLI3, MRC2, TP53 and IQGAP3.

Kui Wu
Xin Zhang
Jianxing He
ResearchOpen Access09 Dec 2015
Nature Communications

Volume: 6, P: 1-13
TMEM150B is dispensable for oocyte maturation and female fertility in mouse

Ran Liu
Hanni Ke
Shidou Zhao
ResearchOpen Access07 Dec 2020
Scientific Reports

Volume: 10, P: 1-7
The formation mechanism of tear strips on stretched Ti-22Al-25Nb alloy sheets

Yingying Zong
Bin Shao
Debin Shan
ResearchOpen Access10 May 2017
Scientific Reports

Volume: 7, P: 1-5
Avian Influenza H5N6 Viruses Exhibit Differing Pathogenicities and Transmissibilities in Mammals

Zongzheng Zhao
Zhendong Guo
Linna Liu
ResearchOpen Access24 Nov 2017
Scientific Reports

Volume: 7, P: 1-6
Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer

The multistep processes involved in the evolution of inflammation to invasive esophageal squamous cell carcinoma (ESCC) is unclear. Here, the authors report a mouse model of ESCC and the role of interplay between carcinogen-transformed epithelial cells and their microenvironment in ESCC development.

Jiacheng Yao
Qionghua Cui
Jianbin Wang
ResearchOpen Access24 Jul 2020
Nature Communications

Volume: 11, P: 1-13
Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study

Jiayu Zhao
Tong Zhou
Jiaming Luo
ResearchOpen Access27 Dec 2024
Translational Psychiatry

Volume: 14, P: 1-9
NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH

Yingying Zhang
Shuting Qiu
Xiaohua Tan
ResearchOpen Access20 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC

Yi Zhang
Yingying Shao
Ping Liu
ResearchOpen Access01 Apr 2024
Cell Death Discovery

Volume: 10, P: 1-15
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF

Jian Sun
Yingying Guo
Haihai Liang
ResearchOpen Access04 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-13
Individualized lncRNA differential expression profile reveals heterogeneity of breast cancer

Zhangxiang Zhao
YingYing Guo
Xia Li
ResearchOpen Access15 Jun 2021
Oncogene

Volume: 40, P: 4604-4614
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

A small-molecule inducer of apoptosis is able to kill senescent cells in the bone marrow of irradiated or aged mice, thereby improving hematopoietic stem cell function.

Jianhui Chang
Yingying Wang
Daohong Zhou
Research14 Dec 2015
Nature Medicine

Volume: 22, P: 78-83
PpINH1, an invertase inhibitor, interacts with vacuolar invertase PpVIN2 in regulating the chilling tolerance of peach fruit

Xingxing Wang
Yi Chen
Xingfeng Shao
ResearchOpen Access01 Oct 2020
Horticulture Research

Volume: 7, P: 1-14
LPS/Bcl3/YAP1 signaling promotes Sox9⁺HNF4α⁺ hepatocyte-mediated liver regeneration after hepatectomy

Changchun Shao
Yingying Jing
Lixin Wei
ResearchOpen Access28 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-12
In silico pharmacogenetics of warfarin metabolism

Yingying Guo
Paul Weller
Gary Peltz
Research05 May 2006
Nature Biotechnology

Volume: 24, P: 531-536
Immunometabolism in cancer: basic mechanisms and new targeting strategy

Ranran Su
Yingying Shao
Yuling Qiu
ReviewsOpen Access16 May 2024
Cell Death Discovery

Volume: 10, P: 1-19
Structured interaction between teacher and student in the flipped classroom enhances learning and interbrain synchrony

Qi Li
Die Wang
Zhishan Hu
ResearchOpen Access03 Dec 2024
npj Science of Learning

Volume: 9, P: 1-10
Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite)

Wenge Chen
Yingying Xiao
Lee Jia
ResearchOpen Access07 Dec 2017
Scientific Reports

Volume: 7, P: 1-11
Author Correction: Avian Influenza H5N6 Viruses Exhibit Differing Pathogenicities and Transmissibilities in Mammals

Zongzheng Zhao
Zhendong Guo
Linna Liu
Amendments and CorrectionsOpen Access08 Jun 2018
Scientific Reports

Volume: 8, P: 1
FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes

Lianqi Shao
Xiangchen Kong
Ying Ying
ResearchOpen Access20 Dec 2024
Cell Death & Disease

Volume: 15, P: 1-12
KLHL29-mediated DDX3X degradation promotes chemosensitivity by abrogating cell cycle checkpoint in triple-negative breast cancer

Litong Yao
Qian Hao
Yingying Xu
ResearchOpen Access16 Oct 2023
Oncogene

Volume: 42, P: 3514-3528
A candidate subunit vaccine induces protective immunity against Mycobacterium avium subspecies paratuberculosis in mice

Mingzhu Shao
Ning Cui
Siguo Liu
ResearchOpen Access20 May 2023
npj Vaccines

Volume: 8, P: 1-13
IL-15 increases the frequency of effector memory CD8⁺ T cells in rhesus monkeys immunized with HIV vaccine

Shirui Li
Xiangrong Qi
Wei He
Research27 Sept 2010
Cellular & Molecular Immunology

Volume: 7, P: 491-494
STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells

Shunli Pan
Xiaoxia Zhao
Dexin Kong
ResearchOpen Access04 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-15
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment

Jialun Li
Ruiping Wang
Jiemin Wong
ResearchOpen Access24 Aug 2020
Cell Discovery

Volume: 6, P: 1-19
Identification and quantitation of the actual active components in bamboo juice and its oral liquid by NMR and UPLC-Q-TOF-MS

Quan Gao
Detao Wang
Qirong Guo
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers

Daisong Wang
Xin Hu
Yi Arial Zeng
Research03 Sept 2019
Cell Research

Volume: 29, P: 832-845
Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers

Haiyang Yu
Shuangshuang Yin
Tao Wang
ResearchOpen Access13 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-13
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth

Chao Zhou
Hongwei Sun
Jianxin Lyu
ResearchOpen Access07 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-14
Global deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interaction

Haiyan Dong
Ji Ma
Lee Jia
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-11

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