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Yin, Lin, Cai, Nie and colleagues report phase separation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in cancer.

Existing solutions based Advanced Encryption Standard to address the security issues of nonvolatile memories incurs significant performance and power overhead. Here, the authors propose a lightweight XOR-gate based encryption/decryption technique by exploiting in-situ array operations, which achieves significant area/latency/power reduction compared to conventional designs.

It may be possible to find non-Abelian electronic states in the higher bands of flat-band materials. Now a detailed transport study of the second moiré band of twisted bilayer MoTe₂ maps out several topological and magnetic states.

The authors enable recording of circuit-scale neuronal voltage dynamics at > 5 kHz sampling rate by using an acquisition pipeline for voltage imaging that assigns each region of interest to a single pixel in the detector, enabling optimally compressed acquisition of intensity traces.

Colloidal suspensions are used as the model systems to study the gelation dynamics because colloidal particles are large and thermal. Here, Li et al.show an alternative system, wet granular packing, whose local structures exhibit fivefold symmetries similar to those observed in colloidal gels.

DeepCAD-RT denoises fluorescence time-lapse images in real time.

Light-driven bioethanol dehydration presents a promising route for sustainable ethylene production. This study unveils a surface hydrogen-replenishment mechanism facilitating ethanol dehydration on GaN nanowires with surface-hydrogenated CrMnOx, achieving an ethylene production rate of 1.78 mol·g_cat⁻¹·h⁻¹.

This study presents a stable and efficient photoelectrochemical system for nitrate reduction to ammonia using metal catalysts on GaN/Si photoelectrodes, offering valuable insights into catalyst design for sustainable ammonia production driven by solar energy.

Selectively extracting U(VI) from seawater is challenging. Here, authors propose a dynamically matched spatial coordination strategy to improve the extraction of U(VI). With the size-matching and the spatial coordination, uranium species are precisely captured in confined coordination space.

MET signalling is required for glioblastoma (GBM) stem cell maintenance. Here the authors identify a circular RNA from the MET gene (circMET) that encodes a MET variant protein (MET404) and show that it can promote GBM tumorigenesis by directly activating the MET receptor independent of HGF stimulation.

Seawater is the most abundant water source for hydrogen fuel production. Here the authors report a binary photoelectrode of Pt catalyst-GaN semiconductor with promising efficiency, productivity, and stability for seawater hydrogen evolution.

Solar photoelectrochemical reactions are one of the most promising paths for sustainable energy production, but systems with high efficiency and long-term stability have remained elusive. Here, the authors show a photoelectrode strategy that enables high efficiency and long-term stability.

Producing valuable chemicals from carbon dioxide, water and sunlight through artificial conversion schemes remains a challenging and ambitious goal in photocatalysis. Here, the authors introduce an effective approach for the synthesis of C₂₊ compounds using a binary AuIr catalyst in combination with InGaN nanowires.

Glass transition shows dramatic dynamic slowdown, but its origin remains unclear. Here, Xia et al. observe in granular systems the rapid growth of a geometrically frustrated polytetrahedral order with packing fraction, which is spatially correlated with the slow dynamics.

An interfacially coupled Cu-cluster/GaN photocathode is designed to overcome the efficiency and stability bottlenecks in photoelectrochemical CO₂ reduction to multicarbon products. The self-optimized Ga–N–O interface facilitates and stabilizes interfacially oxidized copper species of copper clusters, which function as efficient C–C coupling sites for ethylene production.

While water reduction may provide a carbon-neutral means to produce hydrogen gas, there is a scarcity of efficient, earth-abundant electrocatalysts. Here, the authors add palladium into MoS₂ materials to activate and stabilize the conductive basal plane to improve the electrocatalytic activity.

Thermoelectric materials for low-grade heat recovery applications are limited to Bi₂Te₃-based alloys containing expensive Te for decades. Here, the authors demonstrate on a module level, cheap antimonides could enable an efficiency not inferior to that of expensive tellurides.

Breast cancer is frequently diagnosed using ultrasound. Here, the authors show that, in addition to ultrasound, shear wave elastography can be used to diagnose breast cancer and, in conjunction with deep learning and radiomics, can predict whether the disease has spread to axillary lymph nodes.

Photocatalytic water splitting with a high solar-to-hydrogen efficiency of more than nine per cent is achieved using pure water, concentrated solar light and an indium gallium nitride photocatalyst.

Acquired radioresistance is a challenge for the cure of glioblastoma. Here, the authors show that radioresistant glioblastoma boosts mitochondrial fatty acid oxidation that fuels cell proliferation and induces immunosuppression via CD47 mediated anti-phagocytosis. Inhibition of FAO by etomoxir combined with anti-CD47 antibodies sensitizes glioblastoma to radiotherapy.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

It is a general consensus that the structural defects are the plasticity carriers in amorphous solids, but its microscopic view remains largely unknown. Cao et a. show that highly distorted coplanar tetrahedra act as defects in granular packings, which flip under shear to carry local plasticity.

Using readily accessible tropones and γ-methylidene-δ-valerolactones, the divergent synthesis of three classes of challenging [5.5.0] or [4.4.1] bicyclic systems has been achieved—with high efficiency and stereoselectivity—through Pd-catalysed higher-order cycloaddition. Mechanistic studies and density functional theory calculations indicate that the divergent reactions arise from the different reactivity of two diastereomeric intermediates.

Analysis of data from the Born in Guangzhou Cohort Study comprising mainly of trios and mother–infant pairs reveals novel East Asian-specific genetic associations with maternal bile acid, gestational weight gain and infant cord blood traits.