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Showing 1–50 of 71 results

Advanced filters: Author: Yong-Qiang Li Clear advanced filters

In-depth insight into structure-reactivity/regioselectivity relationship of Lewis acid catalyzed cascade 4πe-cyclization/dicycloexpansion reaction

Lewis acid catalyzed tittle reaction of 1,3-dicycloalkenlidine ketones is recognized as so far the shortest and most effective 1-step method for construction of angular tricyclic scaffolds, which are extensively found in bioactive terpenoids. Here, the authors disclose the structure-reactivity relationship and a regioselectivity predicting model based on in situ IR technology, DFT calculations and machine leaning algorithms.

Ka Lu
Pan-Pan Zhou
Jia-Qi Li
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-8
Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening

Here, Li et al. develop a human liver organoid model to elucidate Dengue virus infection dynamics and identify oxyresveratrol as a potential antiviral candidate, highlighting the NRF2 pathway’s crucial role in mitigating mitochondrial damage and enhancing cellular resistance.

Meng-Qi Li
Yan-Peng Xu
Cheng-Feng Qin
ResearchOpen Access28 Aug 2025
Nature Communications

Volume: 16, P: 1-18
The antibody–drug conjugate SHR-A1904 for targeting CLDN18.2 in advanced gastric or gastroesophageal junction cancer: a phase 1 trial

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

Dan-Yun Ruan
Hao-Xiang Wu
Rui-Hua Xu
Research16 Jul 2025
Nature Medicine

Volume: 31, P: 3037-3046
Author Correction: ARF4-mediated intracellular transport as a broad-spectrum antiviral target

Ming-Yuan Li
Kao Deng
Cheng-Feng Qin
Amendments and Corrections23 Jun 2025
Nature Microbiology

Volume: 10, P: 2353
Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells

Zhen-yu Shi
Yong-qiang Li
Bin Liu
Research03 Feb 2012
Acta Pharmacologica Sinica

Volume: 33, P: 271-278
SPA-PNN ligand for the kinetic resolution of carbocyclic and heterocyclic spiranes by asymmetric hydrogenation

Concise and enantioenriched synthesis of chiral carbocyclic and heterocyclic spirane scaffolds is a significant objective in both academic and industrial fields. Here, the authors report the kinetic resolution of racemic spirocyclic 1,3-diketones and their analogues via catalytic asymmetric hydrogenation with the SPA-PNN ligands.

Yong-Yao Li
Ka Lu
Yong-Qiang Tu
ResearchOpen Access02 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions

The bridged medium-sized ring bicyclo[m.n.2] family of natural products are commonly found but difficult to synthesize efficiently. Here the authors present a cascade reaction to form the carbon skeleton, via a [3+2] cycloaddition of a captured azavinyl carbene intermediate.

Bao-Long Hou
Jonathan J. Wong
Chuang-Chuang Li
ResearchOpen Access02 Sept 2021
Nature Communications

Volume: 12, P: 1-8
Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine

(‒)-Morphine is an essential medicine selected by the World Health Organization, however its catalytic asymmetric syntheses have been rarely reported. Here, the authors developed an intramolecular enantioselective Michael addition leading to (‒)-morphine in a longest linear sequence of 16 steps.

Qing Zhang
Fu-Min Zhang
Yong-Qiang Tu
ResearchOpen Access07 Jun 2019
Nature Communications

Volume: 10, P: 1-7
Author Correction: Comprehensive characterization of three classes of Arabidopsis SWI/SNF chromatin remodelling complexes

Jing Guo
Guang Cai
Xin-Jian He
Amendments and Corrections10 May 2023
Nature Plants

Volume: 9, P: 847
ARF4-mediated intracellular transport as a broad-spectrum antiviral target

ARF4 GTPase activity is needed for vesicular trafficking for multiple RNA viruses. Blocking ARF4 using specific peptides redirects viral progeny to lysosomal degradation and decreases influenza and Zika virus infection in mice.

Ming-Yuan Li
Kao Deng
Cheng-Feng Qin
Research19 Feb 2025
Nature Microbiology

Volume: 10, P: 710-723
POWR1 is a domestication gene pleiotropically regulating seed quality and yield in soybean

In soybean production, level of seed protein frequently shows a negative correlation with seed oil content and yield. Here, the authors report a CCT gene pleiotropically regulates these traits and the selection of larger seeds determining allele leads to higher oil content but lower protein content in soybean cultivars.

Wolfgang Goettel
Hengyou Zhang
Yong-qiang Charles An
ResearchOpen Access01 Jun 2022
Nature Communications

Volume: 13, P: 1-11
Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

Yi-Gang Tong
Wei-Feng Shi
Wu-Chun Cao
Amendments and Corrections26 Aug 2015
Nature

Volume: 526, P: 595
Levels of Isopenicillin N Synthetase and Deacetoxycephalosporin C Synthetase in Cephalosporium acremonium Producing High and Low Levels of Cephalosporin C

Yong-Qiang Shen
Saul Wolfe
Arnold L. Demain
Research01 Jan 1986
Bio/Technology

Volume: 4, P: 61-64
Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous outbreaks and that the genetic diversity of the virus has increased substantially, with the emergence of several novel lineages.

Yi-Gang Tong
Wei-Feng Shi
George F. Gao
ResearchOpen Access13 May 2015
Nature

Volume: 524, P: 93-96
Intranasal infection and contact transmission of Zika virus in guinea pigs

Human case studies suggest that Zika virus can be transmitted independently of mosquitoes and sexual contact. Here, the authors show intranasal Zika infection in different animal models and show that contact transmission of Zika virus occurs in guinea pigs.

Yong-Qiang Deng
Na-Na Zhang
Cheng-Feng Qin
ResearchOpen Access21 Nov 2017
Nature Communications

Volume: 8, P: 1-8
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

In this study, Qin et al. present a murine-adapted SARS-CoV-2 strain, MASCp36, as a model for studying the pathogenicity, evolution and adaptation of the virus to human and animal hosts.

Shihui Sun
Hongjing Gu
Cheng-Feng Qin
ResearchOpen Access27 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Comprehensive characterization of three classes of Arabidopsis SWI/SNF chromatin remodelling complexes

Three classes of SWI/SNF chromatin remodelling complexes exist in Arabidopsis that differentially regulate chromatin accessibility, gene expression and development.

Jing Guo
Guang Cai
Xin-Jian He
Research05 Dec 2022
Nature Plants

Volume: 8, P: 1423-1439
DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation

A study using a reverse genetic screen reveals that the Arabidopsis DREAM complex, including its components TCX5/6, functions as a whole in repressing DNA methylation maintenance genes and, consequently, precluding DNA hypermethylation.

Yong-Qiang Ning
Na Liu
Xin-Jian He
Research13 Jul 2020
Nature Plants

Volume: 6, P: 942-956
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.

Yufeng Yu
Yong-Qiang Deng
Lu Lu
ResearchOpen Access25 Jul 2017
Nature Communications

Volume: 8, P: 1-12
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

The suppressive immune microenvironment in colorectal cancer (CRC) liver metastasis remains to be explored. Here, the authors find tumor-associated macrophages in the liver microenvironment induces elevated secretion of FGL1 from cancer cells and hepatocytes which promotes CRC metastasis by suppressing the infiltration of T cells.

Jia-Jun Li
Jin-Hong Wang
Huai-Qiang Ju
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-18
The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing

Transposons and repetitive sequences are typically subject to transcription silencing. Here, Zhang et al. find that the bromodomain-containing protein BRAT1 forms a complex with BRP1, recognizes histone acetylation and acts to prevent transcriptional silencing in Arabidopsis.

Cui-Jun Zhang
Xiao-Mei Hou
Xin-Jian He
ResearchOpen Access07 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Author Correction: The Apostasia genome and the evolution of orchids

Guo-Qiang Zhang
Ke-Wei Liu
Zhong-Jian Liu
Amendments and CorrectionsOpen Access17 Jul 2020
Nature

Volume: 583, P: E30
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes

Qing-song Zheng
Yong-qiang Xiong
Guang Liang
Research11 Jun 2025
Acta Pharmacologica Sinica

P: 1-13
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection

Jia-xuan Yi
Ze-yu Sun
Hua Jiang
ResearchOpen Access01 Oct 2024
Cell Death Discovery

Volume: 10, P: 1-10
Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase

Hui-Ting Chen
Chen Huang
Yong-Jian Zhou
ResearchOpen Access22 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

Monoclonal antibodies with broadly neutralizing activity are being developed as potential treatment of influenza infections. Here, the authors describe a broadly neutralizing antibody with an unusual mode of binding to viral haemagglutinin, which has been isolated from patients convalescent from pandemic H1N1 influenza infection.

Ying Wu
MyungSam Cho
Ruben O. Donis
ResearchOpen Access21 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Approaching the ideal elastic limit of metallic glasses

The elastic limit represents the maximum stress and strain a material can withstand and is well characterized in many crystalline solids, yet remains elusive for metallic glasses. Here, this limit is investigated in submicron metallic glass structures and is found to be twice as high as that of bulk samples.

Lin Tian
Yong-Qiang Cheng
Evan Ma
ResearchOpen Access03 Jan 2012
Nature Communications

Volume: 3, P: 1-6
A Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma

Qiu-Zhong Pan
Qi-Jing Wang
Jian-Chuan Xia
ResearchOpen Access17 Mar 2015
Scientific Reports

Volume: 5, P: 1-7
Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.

Xiao-Feng Li
Hao-Long Dong
Cheng-Feng Qin
ResearchOpen Access14 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Local pressure calibration method of inductively coupled plasma generator based on laser Thomson scattering measurement

Jinhai Sun
Yong-Qiang Liu
Hongbin Ding
ResearchOpen Access18 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Light trapping and surface plasmon enhanced high-performance NIR photodetector

Lin-Bao Luo
Long-Hui Zeng
Ji-Gang Hu
ResearchOpen Access28 Jan 2014
Scientific Reports

Volume: 4, P: 1-8
A Matrix Pencil Algorithm Based Multiband Iterative Fusion Imaging Method

Yong Qiang Zou
Xun Zhang Gao
Yong Xiang Liu
ResearchOpen Access19 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
Immunization with truncated envelope protein of Zika virus induces protective immune response in mice

Jian-Feng Han
Yang Qiu
Cheng-Feng Qin
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Ground-to-satellite quantum teleportation

Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.

Ji-Gang Ren
Ping Xu
Jian-Wei Pan
Research09 Aug 2017
Nature

Volume: 549, P: 70-73
Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome

Meng-yao An
Kai Sun
Jian-shi Lou
Research26 Oct 2017
Acta Pharmacologica Sinica

Volume: 39, P: 382-392
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

Hongyue Li
Yuhang Zhang
Aihua Zheng
ResearchOpen Access10 Nov 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Qiu-Zhong Pan
Jing-Jing Zhao
Jian-Chuan Xia
ResearchOpen Access03 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
The Apostasia genome and the evolution of orchids

WebComparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orchid origins, evolution and diversification.

Guo-Qiang Zhang
Ke-Wei Liu
Zhong-Jian Liu
ResearchOpen Access13 Sept 2017
Nature

Volume: 549, P: 379-383
Transcriptome sequencing of garlic reveals key genes related to the heat stress response

Qing-Qing Yang
Feng Yang
Ji-De Fan
ResearchOpen Access10 Jul 2024
Scientific Reports

Volume: 14, P: 1-17
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Hangping Yao
Yao Sun
Xiangxi Wang
ResearchOpen Access01 Dec 2020
Cell Research

Volume: 31, P: 25-36
Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

Hui Zhao
Tie-Cheng Wang
Cheng-Feng Qin
ResearchOpen Access24 Dec 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-9
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry

Shulong Zu
Dan Luo
Genhong Cheng
ResearchOpen Access21 Dec 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-4
I-BET726 suppresses human skin squamous cell carcinoma cell growth in vitro and in vivo

Zhengjun Liu
Ping Li
Hailei Guo
ResearchOpen Access05 May 2020
Cell Death & Disease

Volume: 11, P: 1-12
A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity

Xing-Yao Huang
Qi Chen
Cheng-Feng Qin
ResearchOpen Access17 Jun 2023
Cell Discovery

Volume: 9, P: 1-13
Author Correction: Pharmacokinetics, mass balance, and metabolism of [¹⁴C]vicagrel, a novel irreversible P2Y₁₂ inhibitor in humans

Yuan-dong Zheng
Hua Zhang
Xing-xing Diao
Amendments and Corrections02 Aug 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2549
Neutrophil-to-lymphocyte ratio as a prognostic biomarker for patients with locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

Xi-Lei Zhou
Yong-Qiang Li
Yu-Suo Tong
ResearchOpen Access14 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression

Jian Zhang
Kewei Hu
Long Cheng
ResearchOpen Access11 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-12
The m⁶A methylome of SARS-CoV-2 in host cells

Jun’e Liu
Yan-Peng Xu
Cheng-Feng Qin
ResearchOpen Access28 Jan 2021
Cell Research

Volume: 31, P: 404-414
Analysis of the characteristics of intestinal microbiota in patients with different severity of obstructive sleep apnea

Pei-Pei Wang
Li-Juan Wang
Bei Wang
ResearchOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice

Yong-Hua Li
Hai-Long Fu
Hong-Bin Yuan
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-12

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