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Scientific Reports (31)
Hypertension Research (13)
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Showing 1–50 of 110 results

Advanced filters: Author: Yoshitaka Nakamura Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The mitotic STAG3–cohesin complex shapes male germline nucleome

Nagano et al. identify the third mitotic cohesin complex, STAG3–cohesin, which, with its unique biophysical properties, weakens insulation and rewires regulatory interactions of spermatogonial stem cells, shaping the male germline nucleome.

Masahiro Nagano
Bo Hu
Mitinori Saitou
Research25 Aug 2025
Nature Structural & Molecular Biology

P: 1-16
ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy

Kaori Nitta
Kunitoshi Shigeyasu
Toshiyoshi Fujiwara
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
The Proportion of Individuals with Alcohol-Induced Hypertension among Total Hypertensives in a General Japanese Population: NIPPON DATA90

Koshi Nakamura
Tomonori Okamura
Hirotsugu Ueshima
Research01 Aug 2007
Hypertension Research

Volume: 30, P: 663-668
Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms

Tatsumaru Fukuda
Masatoshi Takagaki
Haruhiko Kishima
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers

Hiroyuki Konishi
Takao Takahashi
Takashi Takahashi
Research21 Oct 1998
Oncogene

Volume: 17, P: 2095-2100
Upper-plate conduits linked to plate boundary that hosts slow earthquakes

Vertical fluid pathways in the upper plate of the Hyuga-nada subduction zone, Japan, facilitate upward fluid migration from the plate boundary that host slow earthquakes and produce seafloor mud volcanoes.

Ryuta Arai
Seiichi Miura
Kyoko Okino
ResearchOpen Access20 Sept 2023
Nature Communications

Volume: 14, P: 1-9
Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis

Dysregulation of mTORC1 function is linked to various pathological conditions, including addiction. In this study, the authors show that mTORC1 activation in the nucleus accumbens of mice consuming excessive alcohol triggers translational repression through microRNA machinery, which in turn suppresses glycolysis and increases alcohol intake.

Yann Ehinger
Sophie Laguesse
Dorit Ron
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-19
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Unusually stable ~100-fold reversible and instantaneous swelling of inorganic layered materials

Cells are known to swell and shrink in certain solutions, however no inorganic equivalent has been observed to date. Here, the authors demonstrate 100-fold reversible swelling of crystalline lamellar materials, which may be attributed to the long-range directional structuring of intercalated water molecules.

Fengxia Geng
Renzhi Ma
Takayoshi Sasaki
ResearchOpen Access27 Mar 2013
Nature Communications

Volume: 4, P: 1-7
Relationships between family histories of stroke and of hypertension and stroke mortality: Nippon Data80, 1980–1999

Aya Kadota
Tomonori Okamura
Hirotsugu Ueshima
Research01 Aug 2008
Hypertension Research

Volume: 31, P: 1525-1531
Soluble Low Affinity Fc Receptors for IgE in the Serum of Allergic and Nonallergic Children

Kwang-Myong Kim
Mitsuhiko Nanbu
Haruki Mikawa
Research01 Jul 1989
Pediatric Research

Volume: 26, P: 49-53
IgE Receptor-Bearing Lymphocytes in Allergic and Nonallergic Children

Kwang-Myong Kim
Mitsufumi Mayumi
Haruki Mikawa
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 254-257
Two-Site “Simultaneous” Immunoassay with Monoclonal Antibodies for the Determination of Surfactant Apoproteins in Human Amniotic Fluid

Yoshio Kuroki
Hiroki Takahashi
Toyoaki Akino
Research01 Oct 1985
Pediatric Research

Volume: 19, P: 1017-1020
Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene

Yoshitaka Sekido
Mohsen Ahmadian
John D Minna
Research17 Jun 1998
Oncogene

Volume: 16, P: 3151-3157
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Nakamura et al. find that the master transcriptional regulator of lysosomal biogenesis and autophagy TFEB is activated following LC3 lipidation during lysosomal damage and show the importance of this mechanism during kidney injury.

Shuhei Nakamura
Saki Shigeyama
Tamotsu Yoshimori
Research28 Sept 2020
Nature Cell Biology

Volume: 22, P: 1252-1263
Carrier generation and electronic properties of a single-component pure organic metal

The electronic properties of bulk solids composed of zwitterionic tetrathiafulvalene-extended dicarboxylate radicals are investigated, showing highly conducting metallic behaviour in single-component molecular systems having only s and p electrons.

Yuka Kobayashi
Takeshi Terauchi
Yoshitaka Matsushita
Research10 Oct 2016
Nature Materials

Volume: 16, P: 109-114
Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding

Breathing might be crucial for cognition during both offline and online brain states. Here, the authors show that temporal apnea induced by activating the PreBötzinger complex during memory formation resulted in memory impairments.

Nozomu H. Nakamura
Hidemasa Furue
Yoshitaka Oku
ResearchOpen Access27 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Shuhei Nakamura
Saki Shigeyama
Tamotsu Yoshimori
Amendments and Corrections04 Oct 2022
Nature Cell Biology

Volume: 24, P: 1677-1679
Joint Impact of Smoking and Hypertension on Cardiovascular Disease and All-Cause Mortality in Japan: NIPPON DATA80, a 19-Year Follow-Up

Atsushi Hozawa
Tomonori Okamura
Hirotsugu Ueshima
Research01 Dec 2007
Hypertension Research

Volume: 30, P: 1169-1175
Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

Here, the authors perform a genome-wide association study for recurrent pregnancy loss without apparent clinical causes and identify a protective HLA haplotype. They also show that rare predicted loss-of-function variants in CDH11 are associated with risk of recurrent pregnancy loss.

Kyuto Sonehara
Yoshitaka Yano
Mayumi Sugiura-Ogasawara
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-9
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Mast cell maturation is driven via a group III phospholipase A₂-prostaglandin D₂–DP1 receptor paracrine axis

The mechanisms controlling maturation of mast cells toward an anaphylaxis-sensitive phenotype remain unclear. Murakami and colleagues show that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A₂, regulates this process.

Yoshitaka Taketomi
Noriko Ueno
Makoto Murakami
Research28 Apr 2013
Nature Immunology

Volume: 14, P: 554-563
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Decreased extra-renal urate excretion is a common cause of hyperuricemia

Hyperuricemia, or gout, is thought to arise either from urate overproduction or from decreased renal excretion of urate. Ichidaet al. show that the extra-renal excretion of urate also has a role in the pathogenesis of hyperuricemia, and propose a new classification for patients with this disease.

Kimiyoshi Ichida
Hirotaka Matsuo
Hiroshi Suzuki
ResearchOpen Access03 Apr 2012
Nature Communications

Volume: 3, P: 1-7
Dietary diversity and the risk of metabolic syndrome in a Japanese population: an analysis of baseline cross-sectional data from the J-MICC study

Zin Wai Htay
Nobuaki Michihata
Keitaro Matsuo
Research15 Aug 2025
European Journal of Clinical Nutrition

P: 1-8
Vinyl Polymerization. CCCLXXVI. Polymerization of 2,2-Dimethyl-3-oxobutyl Methacrylate

Tatsuro Ouchi
Koji Yokobayashi
Minoru Imoto
Research01 Apr 1979
Polymer Journal

Volume: 11, P: 267-271
Gas Permeation through Poly(N-n-alkylmaleimide) Membranes

Akikazu Matsumoto
Yoshitaka Oki
Takayuki Otsu
Research01 Nov 1991
Polymer Journal

Volume: 23, P: 1371-1375
Correction: Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction

Woojin Kang
Yuichirou Harada
Kenji Miyado
Amendments and CorrectionsOpen Access06 Jan 2020
Laboratory Investigation

Volume: 100, P: 665
Moisture Characteristic and Structure of High Molecular Weight Sericin Film

Hajime Miyake
Hiroyuki Wakisaka
Masanobu Nagura
Research01 Aug 2003
Polymer Journal

Volume: 35, P: 683-687
Suppression of autophagic activity by Rubicon is a signature of aging

Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models.

Shuhei Nakamura
Masaki Oba
Tamotsu Yoshimori
ResearchOpen Access19 Feb 2019
Nature Communications

Volume: 10, P: 1-11
The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer

Whole-transcriptome sequencing of a subset of 75 non-small-cell lung cancer specimens in a multi-institutional genome screening study identified a fusion of the CLIP1 and LTK genes with transformational potential due to constitutive LTK kinase activity.

Hiroki Izumi
Shingo Matsumoto
Koichi Goto
Research24 Nov 2021
Nature

Volume: 600, P: 319-323
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

In a Drosophila imaginal epithelial disc system, mutations that lead to mitochondrial dysfunction can also promote tumorigenic growth of neighbouring cells expressing an activated Ras oncogene.

Shizue Ohsawa
Yoshitaka Sato
Tatsushi Igaki
Research30 Sept 2012
Nature

Volume: 490, P: 547-551
Fibulin-5/DANCE is essential for elastogenesis in vivo

Tomoyuki Nakamura
Pilar Ruiz Lozano
Kenneth R. Chien
Research10 Jan 2002
Nature

Volume: 415, P: 171-175
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Amlodipine-Induced Reduction of Oxidative Stress in the Brain Is Associated with Sympatho-Inhibitory Effects in Stroke-Prone Spontaneously Hypertensive Rats

Yoshitaka Hirooka
Yoshikuni Kimura
Kenji Sunagawa
Research01 Jan 2006
Hypertension Research

Volume: 29, P: 49-56
Secular trends of the impact of overweight and obesity on hypertension in Japan, 1980–2010

Masato Nagai
Takayoshi Ohkubo
Katsuyuki Miura
Research16 Jul 2015
Hypertension Research

Volume: 38, P: 790-795
Integrated molecular analysis of adult T cell leukemia/lymphoma

Seishi Ogawa and colleagues report the results of a large-scale sequencing study of adult T cell leukemia/lymphoma. They find recurrent alterations enriched for T cell receptor/NF-κB signaling, T cell trafficking and other T cell pathways and highlight targets for the development of new therapeutics for this intractable cancer.

Keisuke Kataoka
Yasunobu Nagata
Seishi Ogawa
Research05 Oct 2015
Nature Genetics

Volume: 47, P: 1304-1315
Spin–orbit induced electronic spin separation in semiconductor nanostructures

Achieving spin separation of charged particles in non-uniform magnetic fields is hindered by the Lorentz force. Kohdaet al. demonstrate spin separation in a semiconductor nanostructure by exploiting the effective magnetic field arising from the spin–orbit interaction and achieve highly polarized spin currents.

Makoto Kohda
Shuji Nakamura
Junsaku Nitta
ResearchOpen Access25 Sept 2012
Nature Communications

Volume: 3, P: 1-8
Casein Hydrolysate Containing the Antihypertensive Tripeptides Val-Pro-Pro and Ile-Pro-Pro Improves Vascular Endothelial Function Independent of Blood Pressure–Lowering Effects: Contribution of the Inhibitory Action of Angiotensin-Converting Enzyme

Tatsuhiko Hirota
Kohji Ohki
Masafumi Kitakaze
Research01 Jun 2007
Hypertension Research

Volume: 30, P: 489-496
Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system

Yoshitaka Fukaya
Masayuki Kuroda
Hideaki Bujo
ResearchOpen Access08 Feb 2012
Experimental & Molecular Medicine

Volume: 44, P: 330-339
Low hemoglobin and PSA kinetics are prognostic factors of overall survival in metastatic castration-resistant prostate cancer patients

Yuji Hakozaki
Yuta Yamada
Haruki Kume
ResearchOpen Access15 Feb 2023
Scientific Reports

Volume: 13, P: 1-8
ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer

Nanako Hata
Kunitoshi Shigeyasu
Toshiyoshi Fujiwara
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
Review of the referral documents of patients with malignant soft tissue tumors

Manabu Hoshi
Naoto Oebisu
Hiroaki Nakamura
ResearchOpen Access14 Nov 2022
Scientific Reports

Volume: 12, P: 1-7
Time to castration resistance is a novel prognostic factor of cancer-specific survival in patients with nonmetastatic castration-resistant prostate cancer

Yuji Hakozaki
Yuta Yamada
Haruki Kume
ResearchOpen Access28 Sept 2022
Scientific Reports

Volume: 12, P: 1-8
Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney

Hideyuki Ishiguro
Tatsuhiko Tsunoda
Yoichi Furukawa
Research28 Aug 2001
Oncogene

Volume: 20, P: 5062-5066

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