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Constructing an artificial solid electrolyte interphase to protect the lithium metal electrode is promising but challenging. Here, authors report a facile approach to form a layer to simultaneously overcome diffusion and advection-limited ion transport to achieve dendrite-free Li plating/stripping.

A hybrid extracellular matrix–hydrogel with tunable mechanical stiffness and biochemical composition of young or aged cardiac tissue is used to identify the specific contributions of extracellular matrix ligands and mechanics for fibroblast aging.

Down Syndrome is a common genetic cause of intellectual disability and is associated with altered fetal neurodevelopment. Here, the authors identify altered expression dynamics of lineage commitment genes and de-repression of transposable elements in DS neural progenitor cells.

A topochemical oxidation process is developed to exfoliate metal oxyhydroxides, in which active oxygen species and alkali cations modulate interlayer repulsion. The resulting Cs⁺-CoFeOOH nanosheets demonstrate exceptional electrocatalytic performance for the oxygen evolution reaction.

The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify depletion of ATG9A on cancer cells sensitizes them to macrophage-mediated killing, which can be synergic with CSF1R inhibition in cancer treatment.

Metal halide perovskite is well-known for the high absorption coefficient; however, its Li-ion transport property remains poorly explored. Here the authors coat an ion conducting metal chloride perovskite interfacial layer on the Li metal anode, enabling good battery performance.

A solvent-free and zero-waste method was reported for the synthesis of single-atom catalysts via abrading bulk metal into single atoms. This strategy works for different metals (iron, cobalt, nickel and copper or their alloys) and supports (carbons, oxides or nitrides).

Identification of active sites is one of the main obstacles to rational design of catalysts for scientific and industrial applications. Here, the authors demonstrate the synthesis and structural identification of Zn based active sites, as well as the related structural activation for oxygen species.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

In magnetic materials, geometry-defined competing interactions between spins combined with quantum fluctuations can present the possibility of quantum liquid states which do not order even as 0K is approached. Here, the authors present an analogue built from electric dipoles on a triangular lattice.

A several-fold reduction in temperature is accomplished using a neutral-atom Hubbard quantum simulator by transforming a low-entropy product state into strongly correlated states of interest via dynamic control of the model parameters.

Directed cell movement known as durotaxis, typically associated with cellular migration in response to a substrate gradient of increasing stiffness, is now shown to also occur in the opposite direction, following a gradient of decreasing stiffness.

Design strategies for non-fullerene acceptors are important for achieving high-efficiency organic solar cells. Here the authors design asymmetrically branched alkyl chains on the thiophene unit of the L8-BO acceptor to achieve high crystallinity and photoluminescence quantum yield, yielding over 20% efficiency in single-junction organic solar cells.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Alloy anode materials are receiving renewed interest. Here the authors show the design of Ge-Zn nanofibers for lithium ion batteries. Featured by a homogeneous composition at the atomic level and other favorable structural attributes, the materials allow for impressive electrochemical performance.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Dichloromethane (CH₂Cl₂) is an unregulated ozone depleting substance whose emissions have strongly increased in recent years. Here, the authors show that rising emissions of dichloromethane in China between 2011 and 2019 can explain much of this global increase.

The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and immune cells from SAA patients and assess how these phenotypes change after treatment showing alterations in myeloid cells and TCR clonal abundance correlate with robustness of hematopoietic response.

VEXAS syndrome is a clinically heterogeneous inflammatory condition caused by mutations in the UBA1 gene. Here, by single cell transcriptomics on peripheral blood cells from VEXAS patients, the authors reveal innate and adaptive immune dysregulations irrespective of UBA1 mutations, including the presence of functionally impaired monocytes and clonal expansion of UBA1 wild-type effector memory B cells and plasmablasts.

The benchmark fullerene-based electron-transporting materials (ETMs) for inverted perovskite solar cells are often limited by thermal evaporation or stability issues. Here the authors report solution-processable non-fullerene ETMs with improved device stability and efficiency.

A simple and versatile strategy is established to facilitate molecular recognition by extending electron catalysis for use in supramolecular non-covalent chemistry.

FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and characterize their role in regulating FOXA1 expression and prostate cancer cell growth.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Hard X-ray spectro-imaging using synchrotron radiation can be used to monitor electrochemical reactions. Here, the authors present X-ray absorption data and resolve phase evolution for the conversion of iron fluoride, a high-capacity Li-ion battery conversion cathode, with nanoscale resolution.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Transancestral GWAS meta-analysis in 160,420 individuals identifies 139 loci associated with refractive error, including myopia. Newly identified genes implicate pathways involved in eye growth and light signaling cascades.

A new phylogenomic tree for butterflies is constructed using 391 genes from 2,300 species, representing 92% of genera. It suggests that butterflies originated around 100 million years ago in what is now the Americas and originally fed on Fabaceae.

Federated learning, a method for training artificial intelligence algorithms that protects data privacy, was used to predict future oxygen requirements of symptomatic patients with COVID-19 using data from 20 different institutes across the globe.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Catenanes can exhibit chirality even when their component rings are achiral. Here an isostructural desymmetrization strategy is developed, demonstrating that two achiral rings, each featuring two mirror planes and a two-fold axis of symmetry, can form a catenane with tuneable mechanical chirality.

Left- and right-handed snub cubes show photocontrollable elasticity and hardness, in addition to the ability to encapsulate different small molecules in distinct compartments simultaneously, with potential applications in the development of advanced biomimetic materials.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Genome-wide comparative analysis of DNA binding for 200 transcription factors in two maize inbred lines reveals prevalent genotype-specific variation that is associated with gene expression differences and agronomic traits.

Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive disease. Here, the authors identify recurrent somatic mutations of GNAQ in NKTCL, and model how this mutation contributes to NKTCL pathogenesis.

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

The high charge doping achieved in ionic field-effect transistors by lithium intercalation allows gate-controlled phase transitions in thin flakes of 1T-TaS₂.

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

The Jahn–Teller distortion is an electronic effect that is known to couple charge, orbital and magnetic ordering phenomena in many complex solids. Using a combination of scattering and microscopy approaches, it is now shown that cooperative Jahn–Teller distortions in Na_5/8MnO₂ are coupled to an unusual ordering of Na vacancies.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Acidic CO₂ electroreduction is carbon efficient but suffers from low energy efficiency and selectivity. Here an interfacial cation matrix is developed to enrich alkali cations and increase the local pH at a Cu–Ag catalyst surface, improving efficiency. A 45% CO₂-to-ethanol Faradaic efficiency and 15% energy efficiency for ethanol production are achieved.

Chemical approaches to improve aqueous dispersions of conjugated polymers are limited by the feasibility of modifying the backbone or lead to poor performance. Here, Liu et al. show that ground-state electron transfer in donor:acceptor blends aids aqueous dispersion, for high conductivity and solubility.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Colorectal cancer patients with mismatch repair-deficient, but not MMR-proficient tend to benefit from immune checkpoint blockade therapy. Here, the authors identify interactions among tumor and immune cells that are associated with the responsiveness to immunotherapy in colorectal cancer.

A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.