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SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice

The role of phosphorylated CTD interacting factor-1 (PCIF1) in neuropathic pain-anxiety comorbidity remains elusive. Here, authors identify the SERBP1–PCIF1 complex, which targets m6Am modification in glutamatergic neurons of the S1HL, as a potential therapeutic target.

Yue Huang
Gan Ma
Zhi-Qiang Pan
ResearchOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1-22
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

DNA 6mA is a poorly understood epigenetic mark present at a low abundance in eukaryotic genomes. Here the authors observe high levels in zebrafish and pig during early embryogenesis enriched to repetitive regions of the genome and followed by attenuation during development.

Jianzhao Liu
Yuanxiang Zhu
Chuan He
ResearchOpen Access07 Oct 2016
Nature Communications

Volume: 7, P: 1-7
Liver steatosis mediates the association between metabolic score for insulin resistance and obstructive sleep apnea

Shangyi Song
Xuhao Li
Yuanxiang Liu
ResearchOpen Access09 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
Reconstructing lost BOLD signal in individual participants using deep machine learning

Signal loss in blood oxygen level‐dependent (BOLD) fMRI can lead to misinterpretation of findings. The authors trained a deep learning model to reconstruct compromised BOLD signal in datasets from healthy participants and in patients whose scans suffered signal loss due to intracortical electrodes.

Yuxiang Yan
Louisa Dahmani
Hesheng Liu
ResearchOpen Access07 Oct 2020
Nature Communications

Volume: 11, P: 1-13
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

TBK1 plays a central role in the antiviral innate response. Here the authors identify PTK2B as an interacting protein linked to TBK1 and STING oligomerisation and the activation of STING-TBK1 signaling.

Yongfang Lin
Jing Yang
Qinmiao Sun
ResearchOpen Access21 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Precise multi-factor immediate implant placement decision models based on machine learning

Guanqi Liu
Shudan Deng
Runheng Liu
ResearchOpen Access12 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
A Radiograph Dataset for the Classification, Localization, and Segmentation of Primary Bone Tumors

Shunhan Yao
Yuanxiang Huang
Jiangning Song
ResearchOpen Access16 Jan 2025
Scientific Data

Volume: 12, P: 1-10
A nomogram for predicting the risk of cancer-related cognitive impairment in breast cancer patients based on a scientific symptom model

Zhongtao Zhou
Jiajia Ren
Jing Zhang
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-14
Plasma biomarkers in patients with familial cavernous malformation and their first-degree relatives: a cross-sectional study

Chunwang Li
Shuna Huang
Fuxin Lin
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Structure-based modeling and engineering of Corynebacterium glutamicum LysE transporter for efficient extrusion of L-arginine

Structure-based engineering of Corynebacterium glutamicum LysE transporter enhances L-arginine extrusion via rational mutagenesis, offering a promising strategy for improving the L-Arg production.

Chongzhou Li
Peiwen Lv
Chunyu Yang
ResearchOpen Access02 Apr 2025
Communications Biology

Volume: 8, P: 1-10
Association between dietary caffeine intake and severe headache or migraine in US adults

Lu Zhang
Jiahui Yin
Jiguo Yang
ResearchOpen Access23 Jun 2023
Scientific Reports

Volume: 13, P: 1-8
Multi-stage progressive detection method for water deficit detection in vertical greenery plants

Fei Deng
Xuan Liu
Yuanxiang Huang
ResearchOpen Access26 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma

Longpo Geng
Mingming Zhu
Zhu Xu
ResearchOpen Access12 Jan 2024
Oncogene

Volume: 43, P: 682-692
A potent, broadly protective vaccine against SARS-CoV-2 variants of concern

Ziyan Wang
Jiao An
Ge Liu
ResearchOpen Access12 Nov 2022
npj Vaccines

Volume: 7, P: 1-13
Publisher Correction: Association between dietary caffeine intake and severe headache or migraine in US adults

Lu Zhang
Jiahui Yin
Jiguo Yang
Amendments and CorrectionsOpen Access29 Sept 2023
Scientific Reports

Volume: 13, P: 1
Identification of sex-specific biomarkers related to programmed cell death and analysis of immune cells in ankylosing spondylitis

Tiantian Dong
Xuhao Li
Jiguo Yang
ResearchOpen Access04 Jul 2024
Scientific Reports

Volume: 14, P: 1-17
Pan-cancer discovery of somatic mutations from RNA sequencing data

The authors develop a web resource to present pan-cancer mutations in 32 major types of cancer. This new online somatic mutations atlas, OncoDB is publicly available at https://oncodb.org.

Gongyu Tang
Xinyi Liu
Xiaowei Wang
ResearchOpen Access23 May 2024
Communications Biology

Volume: 7, P: 1-12
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease

Xiaoman Dai
Anlan Lin
Xiaochun Chen
Research06 Dec 2023
Neuropsychopharmacology

Volume: 49, P: 942-952
InGaN micro-light-emitting diodes monolithically grown on Si: achieving ultra-stable operation through polarization and strain engineering

Micro-light-emitting diodes (µLED) with bright, ultra-stable green emissions are monolithically achieved on Si substrate. The quantum-confined Stark effect is screened by introducing polarization doping in the shell.

Yuanpeng Wu
Yixin Xiao
Zetian Mi
ResearchOpen Access10 Oct 2022
Light: Science & Applications

Volume: 11, P: 1-9
Effect of rice straw and swine manure biochar on N₂O emission from paddy soil

Zhanbiao Yang
Yi Yu
Zhang Cheng
ResearchOpen Access02 Jul 2020
Scientific Reports

Volume: 10, P: 1-11

Search

SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice

Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

Liver steatosis mediates the association between metabolic score for insulin resistance and obstructive sleep apnea

Reconstructing lost BOLD signal in individual participants using deep machine learning

PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

Precise multi-factor immediate implant placement decision models based on machine learning

A Radiograph Dataset for the Classification, Localization, and Segmentation of Primary Bone Tumors

A nomogram for predicting the risk of cancer-related cognitive impairment in breast cancer patients based on a scientific symptom model

Plasma biomarkers in patients with familial cavernous malformation and their first-degree relatives: a cross-sectional study

Structure-based modeling and engineering of Corynebacterium glutamicum LysE transporter for efficient extrusion of L-arginine

Association between dietary caffeine intake and severe headache or migraine in US adults

Multi-stage progressive detection method for water deficit detection in vertical greenery plants

TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma

A potent, broadly protective vaccine against SARS-CoV-2 variants of concern

Publisher Correction: Association between dietary caffeine intake and severe headache or migraine in US adults

Identification of sex-specific biomarkers related to programmed cell death and analysis of immune cells in ankylosing spondylitis

Pan-cancer discovery of somatic mutations from RNA sequencing data

Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease

InGaN micro-light-emitting diodes monolithically grown on Si: achieving ultra-stable operation through polarization and strain engineering

Effect of rice straw and swine manure biochar on N₂O emission from paddy soil

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