Nature Search

The PAZ pocket and dimerization drive CpAgo’s guide-independent and DNA-guided dual catalysis

Here the authors identify a unique bacterial Argonaute protein, CpAgo, that uses both guide-dependent and guide-independent mechanisms to degrade DNA/RNA via a previously unidentified PAZ pocket, offering insight into microbial immunity and potential biotechnology applications.

Yuchan Liu
Jiasu Zhang
Shanshan Li
ResearchOpen Access17 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat

Yixin Chen
Ting Zhang
Yanming Chen
Research26 Aug 2025
International Journal of Obesity

P: 1-8
Anti-VEGFR2 F(ab′)₂ drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy

Poor renal distribution of antibody-based drugs limits the treatment efficiency for diabetic nephropathy and causes side effects. Here, the authors prepare an antibody fragment drug conjugate, antiVEGFR2 F(ab′)2-SS31, improving renal distribution and meriting drug validation in diabetic nephropathy therapy.

Di Liu
Yanling Song
Yongzhong Du
ResearchOpen Access13 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

This study identifies the evolutionarily conserved Exportin 4 as an essential regulator in the nuclear export of circRNAs. Defective circRNA export results in R-loop formation and DNA damage in cells, as well as testis and neurological defects in mice.

Liang Chen
Yucong Wang
Ge Shan
ResearchOpen Access01 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Targeting the adenosinergic pathway represents a therapeutic option to overcome tumor-induced immunosuppression. Here the authors design E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses.

Jing Qi
Feiyang Jin
Yongzhong Du
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-17
BMI1 enables interspecies chimerism with human pluripotent stem cells

Conventional human pluripotent stem cells (hPSCs) fail to contribute to interspecies chimaeras when injected into mouse blastocysts. Here the authors show that forced expression of BMI1 overcomes apoptosis of hPSCs in blastocysts of mouse, rabbit and pig allowing them to contribute to chimaeras.

Ke Huang
Yanling Zhu
Guangjin Pan
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Marein from Coreopsis tinctoria Nutt. alleviates oxidative stress and lipid accumulation via SIRT1/Nrf2 signaling

Lisha Zhao
Ruifeng Liu
Lanlan Zhang
ResearchOpen Access28 May 2025
Scientific Reports

Volume: 15, P: 1-11
PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress

Tingting Lan
Fei Bi
Weihua Guo
ResearchOpen Access16 Feb 2023
International Journal of Oral Science

Volume: 15, P: 1-13
Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452

Weimao Zhong
Yuchan Chen
Si Zhang
Research23 Dec 2020
The Journal of Antibiotics

Volume: 74, P: 273-279
Natural forest growth and human induced ecosystem disturbance influence water yield in forests

Natural forest growth does not decrease water yield and forest responses to human disturbances and management interventions vary with ecosystem complexity, according to a global meta-analysis that includes 496 watersheds and spans 25 years.

Zhen Yu
Xiuzhi Chen
Xiang Zhao
ResearchOpen Access27 Jun 2022
Communications Earth & Environment

Volume: 3, P: 1-8
Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells

Yanling Zhu
Tianyu Wang
Guangjin Pan
ResearchOpen Access01 Dec 2020
Cell Discovery

Volume: 6, P: 1-18
New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039

Qingbo Zhang
Sumei Li
Changsheng Zhang
Research24 Oct 2012
The Journal of Antibiotics

Volume: 66, P: 31-36
Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Siwen Niu
Sumei Li
Changsheng Zhang
Research07 Sept 2011
The Journal of Antibiotics

Volume: 64, P: 711-716
Bacteroides ovatus-mediated CD27⁻ MAIT cell activation is associated with obesity-related T2D progression

Yue Li
Yi Yang
Yan Lu
Research11 May 2022
Cellular & Molecular Immunology

Volume: 19, P: 791-804
Alkyl aromatic derivatives from the endophytic fungus Cytospora rhizophorae

Yanjiang Zhang
Hongxin Liu
Haibo Tan
Research27 Dec 2022
The Journal of Antibiotics

Volume: 76, P: 121-130

Search

The PAZ pocket and dimerization drive CpAgo’s guide-independent and DNA-guided dual catalysis

Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat

Anti-VEGFR2 F(ab′)₂ drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy

Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

BMI1 enables interspecies chimerism with human pluripotent stem cells

Marein from Coreopsis tinctoria Nutt. alleviates oxidative stress and lipid accumulation via SIRT1/Nrf2 signaling

PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress

Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452

Natural forest growth and human induced ecosystem disturbance influence water yield in forests

Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells

New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Bacteroides ovatus-mediated CD27⁻ MAIT cell activation is associated with obesity-related T2D progression

Alkyl aromatic derivatives from the endophytic fungus Cytospora rhizophorae

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