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Showing 1–50 of 114 results

Advanced filters: Author: Yuka Suzuki Clear advanced filters

Plasma Immunoreactive Endothelin-1 Concentration in Human Fetal Blood: Its Relation to Asphyxia

Yuka Isozaki-Fukuda
Takatsugu Kojima
Yohnosuke Kobayashi
Research01 Sept 1991
Pediatric Research

Volume: 30, P: 244-247
Induction of tyrosine phosphorylation and association of β-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence

Kazuhide Takahashi
Katsuo Suzuki
Yuka Tsukatani
Research03 Jul 1997
Oncogene

Volume: 15, P: 71-78
Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development

The role of immune-tumor cell interactions in lung adenocarcinoma (LUAD) development remains to be explored. Here, spatial transcriptomics and in situ RNA profiling of samples from 30 LUAD patients reveals changes in the phenotypic properties of tumors cells associated with changes in immune cell features.

Yuma Takano
Jun Suzuki
Ayako Suzuki
ResearchOpen Access06 Dec 2024
Nature Communications

Volume: 15, P: 1-17
Complete chemical structures of human mitochondrial tRNAs

Mitochondrial tRNA modifications are important for tRNA stability and accurate decoding. By employing RNA mass spectrometry and deep sequencing, here the authors provide a comprehensive analysis of post-transcriptional modifications of 22 species of human mitochondrial tRNAs.

Takeo Suzuki
Yuka Yashiro
Tsutomu Suzuki
ResearchOpen Access28 Aug 2020
Nature Communications

Volume: 11, P: 1-15
Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology

Here the authors show that the m¹G9 post-transcriptional methylation differentially regulates the stability of the native and the MELAS variants of human mt-Leu(UAA) tRNA, contributing to mitochondrial pathology.

Sunita Maharjan
Howard Gamper
Ya-Ming Hou
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
A protein language model for exploring viral fitness landscapes

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

Jumpei Ito
Adam Strange
Kei Sato
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-16
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Tomokazu Tamura
Takashi Irie
Takasuke Fukuhara
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Deep learning model for screening causes of activated partial thromboplastin time prolongation using clot waveform analysis at multiple wavelengths

Masato Matsuda
Daiki Shimomura
Tomoko Matsumoto
ResearchOpen Access02 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Depletion of central memory CD8⁺ T cells might impede the antitumor therapeutic effect of Mogamulizumab

Elimination of regulatory T cells via the anti-CCR4 monoclonal antibody, mogamulizumab, is expected to augment anti-tumour immune response. Authors show here that although regulatory T cell targeting is successful, clinical improvement remains minimal in patients with solid tumours due to concomitant and unintended depletion of central memory CD8⁺ T cells.

Yuka Maeda
Hisashi Wada
Hiroyoshi Nishikawa
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-13
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Poor access to suitable light-sheet microscopes remains a big obstacle for many end-users in biomedical research. Here, the authors present descSPIM, a low-cost, low-expertise light-sheet microscope for routine 3D imaging of cleared samples.

Kohei Otomo
Takaki Omura
Etsuo A. Susaki
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Functional variants in a TTTG microsatellite on 15q26.1 cause familial nonautoimmune thyroid abnormalities

Noncoding variants in a TTTG microsatellite on 15q26.1 are identified in Japanese patients with childhood and adult-onset thyroid abnormalities. Functional analyses suggest that these variants affect the role of the microsatellite as a potential regulator of thyroid cell growth.

Satoshi Narumi
Keisuke Nagasaki
Tomonobu Hasegawa
ResearchOpen Access07 May 2024
Nature Genetics

Volume: 56, P: 869-876
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T and CXCL9+ cells after radiotherapy combined with anti-PD-L1 therapy

Shunsuke A. Sakai
Hidekazu Oyoshi
Shun-Ichiro Kageyama
ResearchOpen Access16 Jul 2025
British Journal of Cancer

Volume: 133, P: 795-808
Parameter analysis using swallowing sounds shows differences in bolus volume, bolus viscosity, sex, and age

Yuka Konoike
Kei Naramura
Toshiko Suzuki-Yamamoto
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Two-step regulation of centromere distribution by condensin II and the nuclear envelope proteins

In Arabidopsis cells undergoing mitosis, centromere distribution is shown to be regulated by two steps: scattering in M-phase and stabilization in interphase. This may affect the maintenance of genome integrity rather than gene regulation.

Takuya Sakamoto
Yuki Sakamoto
Sachihiro Matsunaga
Research01 Aug 2022
Nature Plants

Volume: 8, P: 940-953
Any modality of renal replacement therapy can be a treatment option for Joubert syndrome

Yoko Takagi
Kenichiro Miura
Motoshi Hattori
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-7
Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells

Spermatogonia establishment in the fetal and postnatal period is essential for spermatozoa production. Here the authors present a protocol for in vitro reconstitution of human prospermatogonial specification and perform single cell RNA-sequencing to delineate lineage trajectories.

Young Sun Hwang
Shinnosuke Suzuki
Kotaro Sasaki
ResearchOpen Access09 Nov 2020
Nature Communications

Volume: 11, P: 1-17
Mechanism of aminoacyl-tRNA acetylation by an aminoacyl-tRNA acetyltransferase AtaT from enterohemorrhagic E. coli

AtaT is a type-II toxin from enterohemorrhagic E. coli, reported to acetylate the aminoacyl-moiety of initiator Met-tRNAf^Met, thus inhibiting translation initiation. Biochemical analysis suggests that AtaT has a broader specificity for aminoacyl-tRNAs and inhibits global translation. Structure of AtaT in complex with acetylated Met-tRNAf^Met offers insight into the substrate selection by the enzyme.

Yuka Yashiro
Yuriko Sakaguchi
Kozo Tomita
ResearchOpen Access28 Oct 2020
Nature Communications

Volume: 11, P: 1-12
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Live-cell imaging of nuclear–chromosomal dynamics in bovine in vitro fertilised embryos

Tatsuma Yao
Rie Suzuki
Satoshi Sugimura
ResearchOpen Access10 May 2018
Scientific Reports

Volume: 8, P: 1-9
Microbial ligand-independent regulation of lymphopoiesis by NOD1

Iwawura et al. identify a noncanonical role for NOD1, independent from its CARD-mediated proteoglycan sensing. Interactions between NOD1 and STAT5 are required for optimal lymphopoiesis in response to homeostatic cytokines.

Chiaki Iwamura
Hidetaka Ohnuki
Dragana Jankovic
Research13 Nov 2023
Nature Immunology

Volume: 24, P: 2080-2090
Effect of Olmesartan on Oxidative Stress in Hemodialysis Patients

Daisuke Kadowaki
Makoto Anraku
Masaki Otagiri
Research01 May 2007
Hypertension Research

Volume: 30, P: 395-402
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk

MEGAnE is a new tool to detect and genotype mobile element variants (MEVs) from short-read whole-genome sequencing datasets. Genetic analyses implicate MEVs as population-specific drivers of gene expression variation and disease risk.

Shohei Kojima
Satoshi Koyama
Nicholas F. Parrish
Research11 May 2023
Nature Genetics

Volume: 55, P: 939-951
Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs

Keiji Minakawa
Satoshi Ono
Kazuhiko Ikeda
ResearchOpen Access09 Dec 2022
Scientific Reports

Volume: 12, P: 1-9
Visibility of early gastric cancers by texture and color enhancement imaging using a high-definition ultrathin transnasal endoscope

Yohei Koyama
Mitsushige Sugimoto
Takao Itoi
ResearchOpen Access03 Feb 2023
Scientific Reports

Volume: 13, P: 1-8
High-temperature water–rock interactions and hydrothermal environments in the chondrite-like core of Enceladus

Observations indicate that the southern hemisphere of Enceladus is geologically active, with spray containing Si nanoparticles being ejected from an underground ocean. Here, the authors report that experiments to constrain reaction conditions suggest the core is similar to that of carbonaceous chondrites.

Yasuhito Sekine
Takazo Shibuya
Sin-iti Sirono
ResearchOpen Access27 Oct 2015
Nature Communications

Volume: 6, P: 1-8
Association of red blood cell and platelet transfusions with persistent inflammation, immunosuppression, and catabolism syndrome in critically ill patients

Ginga Suzuki
Ryo Ichibayashi
Mitsuru Honda
ResearchOpen Access12 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study

Mizuki Ohashi
Katsuyuki Miura
Hiroaki Ikezaki
Research14 Jan 2022
Hypertension Research

Volume: 45, P: 708-714
Negative-pressure wound therapy is effective for peritoneal dialysis catheter exit-site management in the early postoperative period

Haruna Fukuzaki
Junichiro Nakata
Yusuke Suzuki
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
Environmental RNA interference in two-spotted spider mite, Tetranychus urticae, reveals dsRNA processing requirements for efficient RNAi response

Nicolas Bensoussan
Sameer Dixit
Vojislava Grbic
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-16
Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity

Yohko Yoshida
Ippei Shimizu
Tohru Minamino
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-7
Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study

Rieko Okada
Yuka Kadomatsu
Kenji Wakai
Research03 Sept 2019
Journal of Human Hypertension

Volume: 34, P: 125-131
High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events

Yuki Suzuki
Nobuaki Sakai
Kunio Takeyasu
ResearchOpen Access04 Jul 2013
Scientific Reports

Volume: 3, P: 1-7
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors

Akiyoshi Nakayama
Hirotaka Matsuo
Nariyoshi Shinomiya
ResearchOpen Access09 Jun 2014
Scientific Reports

Volume: 4, P: 1-5
Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection

Chronic infection with the bacterium Helicobacter pylori is associated with inflammation and increased risk of gastric cancer. Kiga et al. show that methylation and silencing of the microRNA gene miR-210is associated with infection in humans, and promotes proliferation of gastric epithelial cells in culture.

Kotaro Kiga
Hitomi Mimuro
Chihiro Sasakawa
ResearchOpen Access04 Sept 2014
Nature Communications

Volume: 5, P: 1-11
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

Mutations in the EZH2 gene are found in myelodysplastic syndrome (MDS) and are often accompanied by mutations in RUNX1. Here, the authors develop a mouse model of MDS and show that EZH2loss enhances the RUNX1-mediated MDS pathology.

Goro Sashida
Hironori Harada
Atsushi Iwama
Research23 Jun 2014
Nature Communications

Volume: 5, P: 1-14
Association between the duration of mothers’ digital media use while with their children and two-year-old children’s development from the Japan Environment and Children’s Study

Yuka Ogata
Takatomo Matsumoto
Takahiko Katoh
ResearchOpen Access24 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
DDX1 is required for non-spliceosomal splicing of tRNAs but not of XBP1 mRNA

RTCB is required for the splicing of both tRNA and XBP1 mRNA, whereas the DDX1 enzymatic activity is specifically required for tRNA splicing in vivo.

Teruhiko Suzuki
Satoko Takagi
Takahiko Hara
ResearchOpen Access20 Jan 2025
Communications Biology

Volume: 8, P: 1-8
Evaluation of repositioning care provided by non-professionals using a caregiver-assistive device: an experimental study

Yuka Omura
Atsuko Watanabe
Tomoko Inoue
ResearchOpen Access30 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

The authors developed a vaccine against a membrane-bound seno-antigen called GPNMB and show that it can be used as a new senolytic approach. The vaccine led to improvements of several age-related phenotypes and prolonged the lifespan of a progeroid mouse model.

Masayoshi Suda
Ippei Shimizu
Tohru Minamino
Research10 Dec 2021
Nature Aging

Volume: 1, P: 1117-1126
Neutralizing immunity against coronaviruses in Tanzanian health care workers

Godfrey Barabona
Isaac Ngare
Takamasa Ueno
ResearchOpen Access06 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Biallelic missense CEP55 variants cause prenatal MARCH syndrome

Li Fu
Yuka Yamamoto
Naomichi Matsumoto
Research16 Oct 2024
Journal of Human Genetics

Volume: 70, P: 63-66
Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation

DUS1L was identified as the human tRNA dihydrouridine writer for positions 16 and 17. DUS1L overexpression changes the amount of several D16/D17-containing tRNAs and increases total cellular translation and cell growth in glioblastoma cells.

Jin Matsuura
Shinichiro Akichika
Takeshi Chujo
ResearchOpen Access02 Oct 2024
Communications Biology

Volume: 7, P: 1-12
Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261

Nambo, Nishiwaki-Ohkawa, Ito, Ariki et al. characterize a novel thyroid hormone analog, ZTA-261. The authors demonstrate a favorable toxicity profile and effects on lipid metabolism in a high fat diet-induced mouse model of obesity.

Masakazu Nambo
Taeko Nishiwaki-Ohkawa
Takashi Yoshimura
ResearchOpen Access06 Aug 2024
Communications Medicine

Volume: 4, P: 1-14
Evolving Japanese regulations on companion diagnostics

Sumimasa Nagai
Masaaki Urata
Mayumi Shikano
Correspondence05 Jan 2016
Nature Biotechnology

Volume: 34, P: 141-144
Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel

Yui Okamura
Kei Gochi
Satoru Takahashi
ResearchOpen Access20 Nov 2024
Scientific Reports

Volume: 14, P: 1-14

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