Multiple sclerosis and some other neuroinflammatory diseases are associated with aberrant CD4+ T cell differentiation and regulatory T cell function. Here authors show that the E3 ubiquitin ligase RNF213 is central to both physiological and pathologic CD4+ T cell differentiation, and finetunes IFN-β responses in multiple sclerosis.
- Xiaofan Yang
- Xiaotong Zhu
- Shengfeng Hu
