Elongation factor G (EF-G) facilitates the movement of tRNA and mRNA by one codon, which is coupled to the ratchet-like rotation of the ribosome complex and is triggered by EF-G–mediated GTP hydrolysis. The crystal structure of pretranslocational ribosome bound to EF-G trapped with a GTP analog provides insight into how the ribosome and EF-G are coordinated to modulate the GTPase activity.
- Yun Chen
- Shu Feng
- Yong-Gui Gao