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Developing strategies for reducing carbon emissions in municipal solid waste management is essential to achieve the net-zero target. Here the authors systematically assess strategy options of different countries for achieving net-zero municipal solid waste management.

While it is possible to synthesize two-dimensional covalent organic frameworks with reversible stacking phases and thus pore sizes, it is challenging because the slipped AA-stacking is the most thermodynamically stable phase. Here, the authors report shape memory 2D covalent organic frameworks with reversible interlayer stacking sequences.

Wireless, portable hydrogel electrochemical systems provide on-demand hydrogen generation and localized delivery, offering a targeted therapeutic solution to mitigate oxidative stress in ischemia-reperfusion injuries while establishing a platform technology for precision gas therapy and controlled drug delivery.

Zhang et al. present a differentiable-physics simulation approach that enables autonomous aerial robot swarms to navigate complex environments. High-speed navigation and robust performance in both multi-agent and single-agent scenarios are demonstrated with low-cost hardware platforms.

Site-selective C–H functionalization of silanes is challenging because of the presence of multiple C–H bonds in the same molecule. Now a general photocatalytic site-selective radical functionalization of organosilicon compounds is reported, enabled by the β-silicon effect, which activates β-C(sp³)–H bonds. These reactions are applicable to linear and complex cyclic silanes.

Previous studies have suggested that branched chain amino acids (BCAA) may contribute to the development of diabetic kidney disease (DKD).Here the authors report that genetic disruption of BCAA catabolism in podocytes or exogenous BCAA supplementation can trigger DKD initiation via rewiring of glucose metabolism in mice.

Variation in DNR1, a negative regulator of nitrate-use efficiency, contributes to a stronger response to elevated CO₂ levels in indica rice than in japonica rice. This finding could inform breeding efforts to enhance rice yields as CO₂ levels rise.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

A microphase crosslinking strategy, leveraging aziridine-based crosslinkers, is used to render organic thermoelectric materials stretchable and elastic.

The decarbonization of energy systems requires access to minerals that are critical for manufacturing low-carbon technologies. Here researchers show that meeting climate targets could be impeded by material shortages, revealing the importance of diverse solutions that balance mitigation, equity and resource constraints.

A computational framework to integrate microbial GWAS and single-cell RNA-sequencing profiles of 24 human organs reveals interactions between the host cells and microbes.

Creating highly active materials that effectively harness solar spectra is essential for photocatalysis, though challenging. Here the authors introduce a novel donor-acceptor covalent organic framework with a broad absorption range of 200 nm to 900 nm, achieving efficient artificial photocatalytic amine coupling.

The exact mechanism of singlet fission remains unresolved. Here, Wang et al. report a quantitative measurement of the interaction between singlet-fission-induced correlated triplets in tetracene crystals with quantum beat spectroscopy, indicating the role played by exciton delocalization in singlet fission.

Fan and colleagues show that the neurotransmitter GABA signals in intestinal ILC3s to suppress IL-17A production through a regulatory loop that involves suppression of C/EBP-β and induction of Igfb7.

Rhombohedral-stacked (R-stacked) transition metal dichalcogenide bilayers exhibit remarkable properties, but their large-area epitaxial growth remains challenging. Here, the authors report the remote epitaxy of centimetre-scale single-crystal R-stacked WS₂ bilayer films on sapphire substrates.

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

Venous thromboembolism is a serious condition influenced by genetics, but current protein-based analyses often miss complex patterns. Here, the authors show that a new non-linear analysis method reveals 43 associated proteins, including eight missed by traditional models, offering deeper insight into disease mechanisms.

Conventional binders in S positive electrodes of Li | |S batteries often lack strength and structure. Here, authors develop an additive-free method to create ordered, cross-linked polyacrylamide networks using γ-ray irradiation, enhancing electrode stability and binder performance.

Xu et al. establish the importance of H2A.Z in mouse oocyte development. H2A.Z is incorporated into chromatin at promoters and putative enhancers, and its presence promotes histone acetylation in fully grown oocytes.

Recent studies have reported the growth of 2D non-centrosymmetric single crystals on substrates with surface steps, but the mechanisms are still unclear. Here, the authors demonstrate a method to grow unidirectionally aligned transition metal dichalcogenide grains on various types of substrates, showing the importance of the simultaneous formation of grain nuclei and substrate steps.

Therapeutic checkpoint for acute myeloid leukemia requires further investigations. The authors here identify ST2⁺ Treg cells facilitate AML growth by inducing CD8⁺ T cell depletion and exhaustion, while targeting ST2 by antibodies depletes ST2⁺ Treg cells and improves AML prognosis.

Large drop in efficiency at high brightness has been holding back the development of various light-emitting diodes including halide perovskite. Here Zou et al. achieve high quantum efficiency of 10% under a high current density of 500 mA cm⁻² in perovskite-based diodes by reducing luminescence quenching.

Controlled breaking of a chemical bond by mechanical forces can provide key insight into reaction mechanisms. Here the authors, using atomic force microscopy and computations, measure the forces involved in breaking a single dative bond between a CO molecule and a ferrous phthalocyanine complex.

The authors report a catalyst featuring Rh-Zn dual sites in a MoS₂ lattice integrated with TiO₂ for the photocatalytic carbonylation of CH₄ with CO and O₂ to CH₃COOH with a high productivity of 152.0 μmol g_cat.⁻¹ h⁻¹ and selectivity of 96.5%.

A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

Broad and potent neutralizing antibodies to SARS-CoV-2 variants can be efficiently identified via accurate deep-mutational-scanning-based prediction of viral evolution and delivered to mice using mRNA–lipid nanoparticles.

Maternal SETD2 deficiency leads to loss of H3K36me3, aberrant DNA methylation and ectopic H3K4me3 and H3K27me3 in mouse oocytes. Maternal depletion of SETD2 causes oocyte defects and subsequent zygotic arrest.

Two-dimensional conjugated coordination polymers can show large electrical conductivity. Here, the authors synthesize high-quality single crystals of Cu₃BHT to unveil the atomic structure and intrinsic superconducting properties.

Genome-wide maps of chromatin dynamics during mouse gastrulation highlight a unique bivalent signature at developmental genes in E6.5 epiblast cells. KMT2B is essential for bivalent H3K4me3 at E6.5.

Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.

Small modular reactors are compact nuclear reactors that can be combined to create large-scale power plants. Here, authors demonstrate the practical feasibility of a multi-modular design in the HTR-PM nuclear plant, showing effective coordinated control of multiple reactor modules driving a common steam turbine for power generation.

Biochemical and structural studies of the interactions between antibodies and spike proteins from SARS-CoV-2 Omicron subvariants indicate how these variants have evolved to escape antibody-mediated neutralization.

Extreme myopia (EM) is a leading cause of sight impairment caused by progressive retinal degeneration. Here, the authors perform whole-exome sequencing to investigate rare protein-truncating variants among EM cases and identify KDELR3 which contributes to the pathogenesis of EM.

Tuberculosis is a major global health issue. Here the authors report Mycobacterium-pre-activated macrophage membrane-coated photothermal nanoparticles for targeted tuberculous granuloma and pathogen dual imaging and antibacterial photothermal therapy.

Controllable synthesis of higher alcohols from CO hydrogenation remains a great challenge. Here the authors show that potassium-decorated edge-rich MoS₂ enables selective CO hydrogenation to higher alcohols by regulating the reaction kinetics of C-O cleavage, C-C coupling and desorption of alcohols.

Methods for the wireless, continuous monitoring and analysis of activities directly from the throat skin have not been developed. Here, the authors present a stretchable device platform that provides wireless measurements and machine learning-based analysis of vibrations and muscle electrical activities from the throat.

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

Current lithium-ion battery recycling extracts valuable metals while discarding much of the battery’s leftover value. An emerging strategy called direct battery regeneration upends this model, restoring the battery’s performance without taking it apart — presenting a more efficient, sustainable option for end-of-life batteries.

Sakuranetin is an important phytoalexin. The authors find that sakuranetin in rice attenuates endocytosis of effectors from the fungus Magnaporthe oryzae and enhances resistance against rice blast.

Convergent mutations in hotspots of the SARS-CoV-2 Omicron receptor-binding domain can cause immune evasion and maintain sufficient ACE2-binding capability.

The electrocatalytic NO reduction reaction enables sustainable NH₃ synthesis and NO removal but faces challenges in achieving industrial-level efficiency and durability. Here the authors present an in situ-formed copper nanowire array monolithic electrode integrated into a pressurized electrolyzer for stable ammonia electrosynthesis at around 1000 mA cm^–2 for 100 h.