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Antiferromagnetic materials are potentially useful for spintronic applications. Here, the authors report high thermoelectric power value of 390 μV/K Seebeck coefficient in IrMn-based half magnetic tunnel junctions at room temperature.

Chiral polar-skyrmion bubbles are observed in superlattices of titanium-based perovskite oxides at room temperature.

Electrochemical technologies for ore refinement provide a unique opportunity to integrate with renewable energy sources but are impeded by the insulating properties of many ores. Here, the authors take inspiration from the lithium-ion battery field and fabricate hectorite–carbon black composite electrodes to enhance electron percolation into hectorite enabling lithium-ion release through a multi-step (electro)chemical mechanism.

A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq, a recently developed spatial transcriptomics method with near-cellular resolution, across the entire mouse brain.

Two-dimensional transition-metal-dichalcogenide materials should have strong piezoelectric properties, making them useful for nanosensors and piezotronics. Here, the authors experimentally demonstrate the piezoelectric effect in monolayer molybdenum disulfide and show how this can modulate conductivity.

This paper presents a high resolution structure of the cytoplasmic polyhedroasis virus (CPV) obtained by single particle cryo electron microscopy, and shows that the polypeptide backbone can be traced without the need of making a crystal.

External ecological interactions and intrinsic biological parameters affect evolutionary pathways and animal diversity. Here, the authors use ruminant inner ear morphology to investigate patterns of diversity through 33 million years, finding clade-dependent climate and paleogeographic trends.

Lasing is experimentally demonstrated in a direct bandgap GeSn alloy, grown directly onto Si(001). The authors observe a clear lasing threshold as well as linewidth narrowing at low temperatures.

Cell type mapping in spatial transcriptomics is enabled by accounting for compositional mixtures and differences in sequencing technologies.

Here, Smalleyet al. demonstrate luminescent hyperbolic metasurfaces wherein quantum heterostructures simultaneously function as the emission source and constituent dielectric. The design enables extreme polarization anisotropy of photoluminescence and efficient extraction of in-plane surface modes.

The insertion of La_1−xSr_xMnO₃ in the interface between LaAlO₃ and SrTiO₃ enhances the electron mobility due to charge-transfer-induced modulation doping. Shubnikov–de Haas oscillations and fingerprints of the quantum Hall effect are observed.

A monolithic heterostructure nanosheet composed of a ZnCdSSe multi-segment quaternary alloy can simultaneously emit laser light in the red, green and blue.

Bacteriophages can bind targets with only a few copies of a display peptide while most nanoparticles with thousands achieve poor binding. Here the authors form hierarchical arrangements of phage peptides to delivery siRNA across the blood brain barrier.

Room-temperature photon avalanching realized in single thulium-doped upconverting nanocrystals enables super-resolution imaging at near-infrared wavelengths of maximal biological transparency and provides a material platform potentially suitable for other optical technologies.

Constitutive laws underlie most physical processes, but understanding chemo-mechanical expansion in heterogeneous solids is challenging. A physically constrained image-learning approach is now proposed to obtain fundamental insight into dislocations inside battery electrodes.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Ruthenium oxide has attracted recent interest as a non-superconducting material where superconductivity can be induced by epitaxial strain. Here, the authors explore strained (100)-oriented RuO₂ films on TiO₂(100) substrate and reveal strain-induced superconductivity similarly to strained RuO₂(110) films, providing insights into the thickness-dependence and electronic structure mechanisms of superconductivity.

Transient receptor potential (TRP) proteins are Ca²⁺-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation of the TRPV subfamily of channels.

Lightning Pose is an efficient pose estimation approach that requires few labeled training data owing to its semi-supervised learning strategy and ensembling.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

The immune suppressive tumour microenvironment drives recurrence and metastatic disease in prostate cancer. Here authors provide a detailed analysis of the microenvironment via single cell RNA sequencing and high-resolution spatial transcriptomics to identify tumour-dependent changes compared to healthy tissue.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

A competitive-chemical-reaction-based growth mechanism by controlling the kinetic parameters can easily realize the growth of transition metal chalcogenides and transition metal phosphorous chalcogenides with different compositions and phases.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Integrating carbon nanotubes into electronic devices requires quick and non-invasive imaging of the nanostructures for precision positioning. Here, the authors use the base of the nanotubes to nucleate the growth of optically visible organic nanocrystals, which thus enables simple microscopy.

Compared to thin films and other geometries, nanorods can exhibit particularly high performance in solute-intercalation-based energy and information storage devices. Here, the authors use in situ electron microscopy and spectroscopy to study the hydrogenation of palladium nanorods, revealing relationships between nanorod structure and device cyclability and capacity.

An expansion of Porphyromonadaceae in the gut is linked to the pathogenesis and progression of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in the mouse.

Despite approved vaccines and anti-virals to prevent and treat SARS-CoV-2 infection, there is a need for further development of efficient antiviral therapeutic strategy. Here, Zhu et al. develop locked nucleic acid antisense oligonucleotides (LNA ASOs) targeting the 5’ leader sequence of SARS-CoV-2 RNA to interfere with replication of wildtype virus and variants of concern. Daily intranasal administration in K18-hACE2 humanized mice suppresses viral infection in lung.

Plasmons are directly launched in graphene, and their key parameters — propagation and attenuation — are studied with near-field infrared nano-imaging.

The amplitude and wavelength of hyperbolic phonon polaritons in hexagonal boron nitride can be tuned using a monolayer graphene gate.

Peptide-based nanofibres with bioactive proteins attached can now be made such that the protein ligands are introduced in a controlled manner. This tailoring of the nanofibre’s composition enables the ratio of multiple different proteins to be highly tuned within the assemblies. By changing the protein content of the nanofibres, it is possible to adjust the antibody responses in mice to the different nanofibres.

Solid-state phase transitions often involve nucleation of the new phase on defects but a detailed mechanistic understanding has not been established. Here the authors observe spinodal fluctuations at dislocations and grain boundaries in an iron alloy, which may be precursors in a multistep nucleation process.

New World hantaviruses—which cause a severe human respiratory disease—use surface glycoproteins to bind to the human protocadherin-1 protein and enter endothelial cells in vitro; depleting protocadherin-1 in Syrian golden hamsters largely protects against disease.

This work describes inCITE-seq that jointly measures intranuclear protein levels and the transcriptome in single nuclei, which is applied to mouse brain tissue to relate quantitative protein levels of TFs to gene expression programs.

The mechanoreceptor Piezo2 is required for both the Hering–Breuer inflation reflex in adult mice and the inflation of the lungs of newborn mice.

A high-resolution structure of the bacteriophage MS2 sheds light on the structure of the genome and how the genome is delivered into a bacterium.

Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop antiviral agents.

This study visualizes the interior of a dsRNA virus using cryo-electron microscopy, revealing the organization of the genome of cytoplasmic polyhedrosis virus together with its transcriptional enzyme complex in both quiescent and transcribing states.

Hybrid organic-inorganic perovskites (HOIP) have high potential for spintronics applications. Using the circular photogalvanic effect the authors demonstrate the existence of Rashba-splitting in the continuum bands of a 2D layered HOIP that results from inversion symmetry breaking along the growth direction.

Patients with resectable clinical stage III or oligometastatic stage IV melanoma were given neoadjuvant relatlimab and nivolumab combination immunotherapy, which induced a high pathologic complete response rate, indicating the efficacy and safety of this regimen.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Using single-cell RNA sequencing and spatial transcriptomics, Wang et al. recreate a map of glomerular locations in the mouse olfactory bulb. This work describes a spatial organization that may be used by the brain to assist in odor decoding.