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Showing 1–11 of 11 results

Advanced filters: Author: Zachary J. Reitman Clear advanced filters

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.

Zachary J. Reitman
Brenton R. Paolella
Rameen Beroukhim
ResearchOpen Access19 Aug 2019
Nature Communications

Volume: 10, P: 1-17
A consensus guide to preclinical indirect calorimetry experiments

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Alexander S. Banks
David B. Allison
Juleen R. Zierath
Reviews24 Sept 2025
Nature Metabolism

Volume: 7, P: 1765-1780
FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy

Fan and colleagues show that FLASH radiation promotes proinflammatory polarization of tumor-associated macrophages, which in turn increases T cell influx in medulloblastoma and synergizes with CAR-T cell therapy.

Haiwei Ni
Zachary J. Reitman
Yi Fan
Research05 Feb 2025
Nature Cancer

Volume: 6, P: 460-473
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

Hai Yan, Zachary Reitman and colleagues report exome sequencing of resected tumor tissue from brainstem gliomas and thalamic gliomas and identify mutations in PPM1D in brainstem gliomas.

Liwei Zhang
Lee H Chen
Hai Yan
Research01 Jun 2014
Nature Genetics

Volume: 46, P: 726-730
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

PPM1D is a known mediator of p53 signalling, and has been linked to treatment resistance in glioma. In this work, the authors utilise genomics, proteomics, and mouse models to determine the role of PPM1D in the development of diffuse midline glioma.

Prasidda Khadka
Zachary J. Reitman
Pratiti Bandopadhayay
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-18
Enzyme redesign guided by cancer-derived IDH1 mutations

A new approach for rational enzyme design uses gain-of-function cancer mutations to guide homologous mutations in homoisocitrate dehydrogenase, yielding a biocatalytic path to (R)-2-hydroxyadipate, a precursor for the major commodity chemical adipic acid.

Zachary J Reitman
Bryan D Choi
Hai Yan
Research23 Sept 2012
Nature Chemical Biology

Volume: 8, P: 887-889
Enhancing adoptive cell therapy: future strategies for immune cell radioprotection in neuro-oncology

Abigail J. Groth
Mustafa Khasraw
Zachary J. Reitman
ReviewsOpen Access29 Jul 2025
npj Precision Oncology

Volume: 9, P: 1-14
Mining cancer genomes for change-of-metabolic-function mutations

The development of METIS: a computational approach to identify cancer mutations that confer novel catalytic functions upon enzymes, then apply these mutations towards green chemistry or therapeutic development.

Kevin J. Tu
Bill H. Diplas
Zachary J. Reitman
ResearchOpen Access10 Nov 2023
Communications Biology

Volume: 6, P: 1-11
Pooled genetic screens to identify vulnerabilities in TERT-promoter-mutant glioblastoma

Kevin J. Tu
Connor E. Stewart
Zachary J. Reitman
Research23 Sept 2023
Oncogene

Volume: 42, P: 3274-3286
The genome-wide mutational landscape of pituitary adenomas

Zhi-Jian Song
Zachary J Reitman
Yao Zhao
CorrespondenceOpen Access27 Sept 2016
Cell Research

Volume: 26, P: 1255-1259
A multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation

Dominic LaBella
Omaditya Khanna
Evan Calabrese
ResearchOpen Access15 May 2024
Scientific Data

Volume: 11, P: 1-8