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ASXL1 is often mutated in myeloid cancers. Here, the authors describe the molecular and structural mechanism by which ASXL1 associates with the transcriptional coactivator BRD4, helping to explain their high correlation in cancers.

Mechanically interlocked supramolecular compounds have garnered widespread attention but it remains challenging to investigate topological adjustments in such complicated structures. Here, the authors use a bidentate pyridyl ligand featuring an extended π-conjugated plane for coordination-directed self-assembly to engineer three different kinds of sophisticated complexes.

Low outcrossing rate of sterile lines limits hybrid rice seed production. Here, the authors report that mutation of a SET domain-containing protein HER1 leads to enlarged stigma, enhanced stigma exsertion, and hybrid seed production in rice.

Electrocatalytic nitrate reduction in acidic wastewater offers a route to produce ammonia, but faces efficiency challenges. Here, the authors report a Ru/WO_3-x catalyst that uses a proton-management strategy to achieve high ammonia production and enables a device that recovers energy.

Magnetic kagome metals are an ideal platform for investigating the interplay between spin and charge degrees of freedom. Here, the authors provide evidence of a charge-density wave intrinsically coupled to spin degrees of freedom in GdTi₃Bi₄, consistent with a spin–intertwined charge density wave.

Achieving multiple functions in a self-sustained human-machine interface remains challenging. Bai et al. show a hydrogel-based e-skin that integrates thermogalvanic, piezoionic, and diffusion mechanisms for self-powered simultaneous sensing of skin temperature, arterial pulsation, and sweat secretion.

We introduce meta-amplified dark-field interferometric scattering microscopy, which uses a plasmonic metasurface to enhance sensitivity and contrast by converting nanoparticle-induced phase perturbations into strong far-field scattering signals.

Cervical spondylosis is a highly prevalent degenerative disease that lacks visible lesions on medical images, making its diagnosis heavily reliant on scarce expert experience. Here the authors show a cascade-ensemble deep learning framework that achieves expert-level accuracy in diagnosing cervical degeneration by integrating multi-modal imaging data and analyzing key clinical indicators

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Papaya is a trioecious species with XX females, XY males, and XY^h hermaphrodites, and the combination of Y and Y^h chromosomes is lethal. Here, the authors identify the degeneration of the YY lethality gene on the Y chromosome as the causal balancing lethal factor that reenforces dioecy and stabilizes balanced sex ratios.

Zhai et al. report newly designed self-assembled molecules exhibiting strong and ordered anchoring on the perovskite surface to reduce defects and modulate the dipole-induced energy-level, enabling certified efficiencies of 26.23% in a normal device structure, which are also applicable to inverted perovskite solar cells.

Di et al. report a dual-band infrared photodetector employing size-engineered PbS quantum dots as spectrally selective absorbers in a unipolar barrier configuration, which can switch between near- and short-wave infrared region. A 128×128 focal plane array is prepared for practical infrared multispectral imaging.

Granzyme B is an important factor in cytotoxic T lymphocytes anti-tumour immunity. Here, the authors report on a Pd-FTn granzyme B-mimicking nanozyme with a binuclear catalytic centre, delivered by functionalised nanovesicles to selectively trigger caspase-dependent apoptosis for a T cell-inspired cancer therapy.

Grain number per panicle (GNP) is a critical yield component trait of rice. Here, the authors clone a MAPKKK encoding gene GNP3 positively regulating grain yield and show its role in rice panicle development by interacting and destabilizing ethylene biosynthesis related enzyme SADENOSYLMETHIONINE SYNTHETASE 1.

The late Ming megadrought across north-to-south China, lasting from 1625-1644 CE, was influenced by Pacific sea surface temperature anomalies, weakened solar activity, and volcanic eruptions, according to reconstruction of the Yangtze River's water balance using tree-ring chronology.

Nanochannel-confined polymerization enables polymer curing inside nanometre-scale two-dimensional channels. This strategy produces selective, mechanically robust, densely packed membranes and reveals how nanoconfinement reshapes polymer structure and membrane transport pathways, opening a general route to engineer functional materials by controlling chemistry in nanoscale pores.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

The efficacy of the TGF-β×PD-L1 bispecific antibody (BsAb) is not promising clinically. The authors here develop a Y101S, an antibody-drug conjugate targeting TGF-β, PD-L1, and STING, which manifests superior anti-tumor efficacy in preclinical models with the mechanism of enhanced CXCL16 mediated cytotoxic CXCR6⁺ T cells recruitment.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A computational workflow, LyMOI, uses LLM, knowledge graphs and other tools to facilitate ’omic analysis and hypothesis generation related to autophagy.

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

Li et al. report the cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states, revealing the unique architecture and mechanisms of this prokaryotic antiphage system.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

2D diamond is expected to show superior properties compared to bulk diamond, but its synthesis remains challenging. Here, the authors report a high-temperature high-pressure method to fabricate thermally stable 2D diamond via laser-heating of few-layer graphene in a diamond anvil cell, providing relevant insights into the 2D graphene-diamond transformation mechanisms.

A continuously tunable time-programmable 3D metastructure coloration encryption approach with wide-gamut spectral control via refractive-index modulation and capillary-driven self-destruction is presented for high-capacity secure information encryption.

A label-free imaging approach detects differences in NIR-II autofluorescence intensity between human liver malignancy and the adjacent tissue.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

A photocatalytic synthetic route to deuterated N-heteroarenes over an atomically dispersed palladium photocatalyst in D₂O is developed. By recycling used D₂O and photocatalyst, up to 1.157 kg of deuterated N-heteroarenes can be obtained using only 4.5 litres of D₂O (19.7 equiv.).

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Here the authors show a general method to make alkoxide-based network-forming glasses with tunable properties by combining titanium, zirconium and boron-based nodes, multi-dentate alcohol linkers and mono-dentate alcohol modulators.

FUNDC1 in endothelial cell (ECs) via endothelin (ET) 1 release regulates insulin sensitivity and adiposity and that high fat diet feeding promotes obesity, insulin resistance and diabetes by increasing FUNDC1 and consequent ET1 release from ECs.

Zinc-metal batteries are restricted by their inherent high activity of aqueous electrolyte. Here, authors report the design of a new class of zinc-based hybrid metal halide solid-state electrolytes, offering a promising avenue for all-solid-state zinc batteries.