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Multimodal brain recordings are no easy task. Here, the authors introduce a neural implant with integrated carbon nanotube field-effect transistors for multimodal recording of electrical and chemical signals.

The role of Leflunomide in αPD1-induced cardiotoxicity remains unclear. Here, the authors show that leflunomide mitigates αPD1-induced cardiac toxicity in melanoma-bearing mice through modulation of the microbiota-indole-3-propionic acid-heart axis.

High fidelity manipulation of diamond-based spin qubits is difficult at room temperature because of decoherence. Here, the authors show a universal set of logic gates in nitrogen-vacancy centres with average single-qubit and two-qubit gate fidelities of 0.999952 and 0.992, respectively.

Off-the-shelf, on-demand allogeneic CAR-T cells could represent a therapeutic alternative to autologous products for cancer therapy. Here the authors report the preclinical characterization of off-the-shelf CRISPR-Cas9– edited IL-13Rα2-specific allogeneic universal CAR-T cells and the results of a first-in-human phase I trial in patients with high-grade glioma.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A strategy based on the design of a composite coating that enables slip-enhanced close-contact melting inside sealed phase-change thermal batteries to improve charging rates enables high-performance thermal energy storage over a wide range of temperatures.

The clinical adaptation of CRISPR assays is constrained by complexity and the absence of quality control. Here, authors report a thermally regulated asynchronous CRISPR-enhanced assay enabling direct, highly sensitive one-step detection of monkeypox virus and a human gene in clinical samples.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

Controlling the chain length distribution (CLD) of hydrocarbons in plastic degradation is crucial for the downstream synthesis of functional chemicals but controlling the CLD remains challenging. Herein, the authors introduce a fractionated degradation approach to tune the CLD of hydrocarbons derived from polypropylene (PP) degradation, thereby facilitating effective downstream valorization.

The field enhancements arising in plasmonic nanostructures make them ideal as substrates for molecular sensors. In this study, Zhang et al.achieve single molecule sensitivity with Fano resonances in a quadrumer nanostructure and coherent anti-Stokes Raman spectroscopy.

Monolayer transition metal dichalcogenides have so far been thought to be direct bandgap semiconductors. Here, the authors revisit this assumption and find that unstrained monolayer WSe₂ is an indirect-gap material, as evidenced by the observed photoluminescence intensity-energy correlation.

Organoid modeling and single-cell profiling reveal TUBA4A and TUBB4B tubilin proteins-driven vascular smooth muscle cell migration and contractile-to-synthetic phenotypic switching via GJA1/PI3K/AKT/KLF4 pathway in Moyamoya disease.

Azetidine is a pharmacophore present in drug-related molecules. Here the authors unveil a two-metalloenzyme cascade leading to the azetidine-containing polyoximic acid, in which PolE functions as an Fe²⁺/pterin-dependent l-isoleucine desaturase, while PolF is a haem-oxygenase-like diiron oxidase, orchestrating the sequential desaturation and cyclization. These findings expand our knowledge of metalloenzymes.

The production of higher alcohols is very valuable because of their high volumetric energy density. Now, Sargent, Sinton and co-workers report the design of copper nanoparticles with tailored nanocavities that promote n-propanol formation by the coupling of C2 and C1 intermediates inside the cavity.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Fullerene cages that break the isolated pentagon rule are rare and often unstable. Now a range of fullerenes that feature three sequentially fused pentagons of carbon have been stabilized by chlorination.

The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid alleviate inflammatory pain in patients. Ru-Rong Ji and his colleagues find that the resolvins RvE1 and RvD1, which are derived from omega-3 fatty acids, potently reduce pain in a number of animal models of inflammatory pain. These effects are mediated by both peripheral and central mechanisms and suggest that resolvins may represent a new class of analgesics for inflammatory pain (pages 518–520).

Existing method struggles with CHH methylation detection from the reads generated by the latest ONT technology. Here, the authors developed a deep learning model that can significantly improve CHH detection accuracy in plants.

Histone crotonylation is implicated in transcriptional regulation. Here, the authors perform genome-wide mapping of histone crotonylation in mouse and human early embryos. Suppression of histone crotonylation results in developmental arrest at 2-cell stage due to impaired transcriptional activity. Embryos from aged female mice exhibit diminished histone crotonylation, while sodium crotonate supplementation facilitates blastocyst formation.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

Fatigue-resistant functional bioadhesion is desired in diverse applications ranging from wound management to wearable devices but remains elusive. Here, the authors report the design, deployment, and mechanism of nanowhisker glues for fatigue-resistant functional bioadhesion.

CD8 + T cells play an important role in primary biliary cholangitis (PBC). In this study, the authors demonstrate that PD-1-expressing CD8+ liver-resident T cells are pathogenic in murine PBC and that targeting these cells using a chimaeric antigen receptor reduces disease severity.

The authors use an easily available Brønsted acid and zinc triflate as a cooperative catalyst system for methanol activation, inspired by an analogous system used in microorganisms for the same task.

Here, Song and Li et al. show that autophagy-related 8 (Atg8) recruits Atg1 to the surface of autophagosomes to coordinate membrane expansion of the autophagy machinery. Artificial tethering of the Atg1 kinase domain to autophagosomal membranes boosts autophagy in multiple species.

A high-κ dielectric ceramic, magnesium niobate, can be epitaxially grown on a mica substrate and then transferred to form the gate dielectric in molybdenum disulfide transistors, providing van der Waals interfaces and high robustness to temperature and voltage.

Treatment of patients with HER2-mutant non-small-cell lung cancer with the pan-HER inhibitor pyrotinib in a phase 2 trial or compassionate use showed a favorable objective response rate, whereas patients treated in parallel by physician’s choice in a real-world study did not.

Here the authors delineate the dynamic changes in 3D genome and epigenome of differentiating macrophages and during infection with Mycobacterium tuberculosis. They reveal a role for NF-κB upon infection and identify SNPs in disease-susceptible loci, including rs1873613 that is located in the anchor of a dynamic chromatin loop.

Stereoselective synthetic routes use P3HB (a polyester produced by bacteria) as a chiral feedstock for related polymers that have properties more amenable to processing and use.

High mobility group A1 (HMGA1) has been identified to play a role in tumour progression but its involvement in anti-tumour immunity of esophagael squamous cell carcinoma (ESCC) remains unclear. Here the authors report that the inhibition of STING-mediated anti-tumour immunity by HMGA1 results in promotion of ESCC tumorigenesis.

Conventional CRISPR-based approaches to monitor genomic loci can be hampered by high background and nonspecific nucleolar signal. Here, the authors propose a fluorogenic CRISPR (fCRISPR) tool that allows for high-contrast and sensitive imaging of genomic DNA.

The authors propose an optical encryption platform that enhances security and throughput through scattering multiplexing ptychography, realizing encryption at a scale of 10-megapixel pixels with 1.23 µm resolution.

While solar-to-fuel energy conversion is appealing, materials require accessible active sites for reactants and rapid electron transfer steps. Here, authors support ultrathin metal-organic layers with graphene oxide as both template and electron mediator to boost CO₂ photoreduction performance.

PIK3CA is a commonly mutated cancer-associated gene, making it an attractive therapeutic target. Here, the authors report the results of a first-in-human phase Ia trial to assess the safety and recommended phase II dose of CYH33, a PI3Kα inhibitor, in patients with advanced solid tumors.

A new type of surface state has recently been reported in ZrSiSe but its physical properties remain unclear. Here, Zhu, Chang, Huang, et al. report rotational symmetry breaking, healing effect and anomalous Umklapp scattering arising from the nonsymmorphic effect of the floating band state on ZrSiSe (001) surface.

Bats have been suggested to be resistant to cancer due to mechanisms related to their evolved longevity, but the associated molecular drivers are still understudied. Here, the authors examine cancer resistance mechanisms across seven bat species using in vitro and in vivo models, and identify HIF1A, COPS5, and RPS3 as related genes.

Liu and colleagues report that toll-like receptor 7 (TLR7), which is typically thought to be expressed in immune cells and to function to regulate innate immunity, is expressed and acts in C-fiber primary sensory neurons. In mice, they find that TLR7 is important for inducing itch, but is not necessary for eliciting pain.