Nature Search

Author Correction: Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Wei Xia
Jing Xie
Xiaochun Bai
Amendments and CorrectionsOpen Access03 Jul 2025
Nature Communications

Volume: 16, P: 1
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Peixiang Zheng
Zhiqiang Hu
Daqian Xu
Research25 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1420-1432
Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione

It is needed yet difficult to achieve a strategy for synthesizing single-atom nanozymes that integrate atomic metal dispersion, elevated mass transport and tailorable coordination environment. Here, the authors address this issue by developing a biomimetic synthetic strategy and demonstrate the application of the resultant single-atom Fe nanozymes for tumor visual identification.

Da Chen
Zhaoming Xia
Yongquan Qu
ResearchOpen Access06 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination

Radiation-induced tumor vaccination is insufficient to elicit robust antitumor immune response. Here they combine chiral vidarabine monophosphate-gadolinium nanowires with immune checkpoint blockade therapy to synergistically induce antitumor immunity.
Reviewer recognition:

Zhusheng Huang
Rong Gu
Ahu Yuan
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-18
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia

MPHOSPH8 loss inhibits acute myeloid leukemia (AML) development by reactivating LINE-1 retrotransposons. LINE-1 suppression is associated with therapy resistance and poor prognosis in patients with AML.

Zhimin Gu
Yuxuan Liu
Jian Xu
Research08 Apr 2021
Nature Genetics

Volume: 53, P: 672-682
Signature of leukemia stem cell death pattern predicts prognosis and therapeutic response of acute myeloid leukemia patients

Fuqiang Wang
Minjie Li
Zhimin Gu
ResearchOpen Access27 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation

Identifying how genetic alterations cooperate in cancer is challenging. Here the authors analyze leukemia mouse models with both oncogenic NRAS and EZH2 mutations using single-cell RNA-sequencing, evaluate oncogenic cooperation, and identify GEM as a regulator of leukemia-initiating cells.

Yuxuan Liu
Zhimin Gu
Jian Xu
ResearchOpen Access03 Nov 2021
Nature Communications

Volume: 12, P: 1-17
A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions

Epigenetic variation underlies various aspects of phenotypic diversity of plants. Here, He et al show a naturally occurring epiallele controls Arabidopsis leaf senescence by regulating the expression of PHEOPHYTIN PHEOPHORBIDE HYDROLASE (PPH), and is associated with local climate adaptation.

Li He
Wenwu Wu
Jian-Kang Zhu
ResearchOpen Access31 Jan 2018
Nature Communications

Volume: 9, P: 1-11
Magnesium hexacyanoferrate nanocatalysts attenuate chemodrug-induced cardiotoxicity through an anti-apoptosis mechanism driven by modulation of ferrous iron

Doxorubicin is commonly used in cancer chemotherapy, but its cardiotoxicity from iron overload is one of the severe side effects. Here, the authors prepare magnesium hexacyanoferrate nanocatalysts to capture excess ferrous species and eliminate cytotoxic radical species in vitro and in vivo.

Minfeng Huo
Zhimin Tang
Jianlin Shi
ResearchOpen Access15 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Nitrate–NRT1.1B–SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants

In rice, nitrate perception by NRT1.1B activates genetic responses that increase the utilization of not only nitrate but also phosphate. A novel molecular mechanism centred on the presumed Pi sensor SPX4 underlies this nutritional signalling crosstalk.

Bin Hu
Zhimin Jiang
Chengcai Chu
Research25 Mar 2019
Nature Plants

Volume: 5, P: 401-413
Metabolic heterogeneity confers differences in melanoma metastatic potential

Differences in MCT1 function among melanoma cells confer differences in oxidative stress resistance and metastatic potential.

Alpaslan Tasdogan
Brandon Faubert
Sean J. Morrison
Research18 Dec 2019
Nature

Volume: 577, P: 115-120
Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD

There is a low efficiency of A-to-G base conversion in at specific positions using base editors. Here the authors fuse ABE8e with the Rad51 DNA-binding domain to generate a hyperactive ABE allowing improved A-to-G editing efficiency at the region proximal to the PAM and improved simultaneous A/C conversion efficiency.

Niannian Xue
Xu Liu
Xiaohui Zhang
ResearchOpen Access03 Mar 2023
Nature Communications

Volume: 14, P: 1-12
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Concomitant traumatic brain injury accelerates bone healing, but the mechanism is unclear. Here, the authors show that injured neurons, mainly those in the hippocampus, release osteogenic miRNA-enriched small extracellular vesicles, which targete osteoprogenitors to stimulate bone formation.

Wei Xia
Jing Xie
Xiaochun Bai
ResearchOpen Access15 Oct 2021
Nature Communications

Volume: 12, P: 1-18
Observation of flat band, Dirac nodal lines and topological surface states in Kagome superconductor CsTi₃Bi₅

Kagome superconductors host a panoply of condensed matter phenomena, some of which are mediated by band topology. Here, authors use ARPES and DFT to identify type-II and type-III Dirac nodal lines, flat bands and topological surface states in the kagome metal CsTi₃Bi₅.

Jiangang Yang
Xinwei Yi
X. J. Zhou
ResearchOpen Access10 Jul 2023
Nature Communications

Volume: 14, P: 1-8
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis

In this study, Patrick et al. provide insight into the regulation of branched-chain amino acid metabolism and its impact on whole-body physiology by identifying and characterizing a metabolon formation.

McKenzie Patrick
Zhimin Gu
Jian Xu
Research28 Nov 2022
Nature Metabolism

Volume: 4, P: 1775-1791
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers

During aging, the ability of skeletal muscle to repair itself declines, in part due to a decrease in muscle stem cells. Here, the authors report that muscle stem cells that accumulate mitochondrial damage fuse with existing muscle fibers in a manner that depends on the induction of Scinderin.

Xun Wang
Spencer D. Shelton
Prashant Mishra
ResearchOpen Access27 Jan 2022
Nature Aging

Volume: 2, P: 155-169
TCRP1 transcriptionally regulated by c-Myc confers cancer chemoresistance in tongue and lung cancer

Xiaoting Jia
Zhijie Zhang
Zhimin He
ResearchOpen Access16 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing

Tissues-specific gene expression requires coordinated cis-regulatory elements. Here the authors use dCas9-based enhancer targeting to remodel local epigenetic landscapes and activate or inactive transcription.

Kailong Li
Yuxuan Liu
Jian Xu
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Lymph protects metastasizing melanoma cells from ferroptosis

Melanoma cells undergo less oxidative stress and less ferroptosis in lymph than in blood, owing to higher levels of oleic acid in lymph, and thus exposure to the lymphatic environment increases subsequent metastasis through blood.

Jessalyn M. Ubellacker
Alpaslan Tasdogan
Sean J. Morrison
Research19 Aug 2020
Nature

Volume: 585, P: 113-118
Click-ExM enables expansion microscopy for all biomolecules

Click-ExM uses click-chemistry-based labeling to increase the versatility of expansion microscopy. Click-ExM enables imaging of numerous classes of biomolecules including lipids, glycans, proteins, DNA, RNA and small molecules.

De-en Sun
Xinqi Fan
Xing Chen
Research07 Dec 2020
Nature Methods

Volume: 18, P: 107-113
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

Xin Liu
Yuannyu Zhang
Jian Xu
Research15 May 2017
Nature Cell Biology

Volume: 19, P: 626-638
The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium

Chunyi Ji
Yiqi Wang
Jing Ji
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-13
Elevated ITGA3 expression serves as a novel prognostic biomarker and regulates tumor progression in cervical cancer

Wei Tan
Gantao Chen
Yanxiang Cheng
ResearchOpen Access07 Nov 2024
Scientific Reports

Volume: 14, P: 1-16
ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells

Xuedong Wang
Yueping Wang
Soldano Ferrone
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Xinyi Yang
Xu Zheng
Huanzhang Zhu
ResearchOpen Access14 Feb 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth

Xiaojun Ren
Jimei Yan
Jianxin Lyu
ResearchOpen Access25 Jul 2023
Cell Discovery

Volume: 9, P: 1-18
REST, regulated by RA through miR-29a and the proteasome pathway, plays a crucial role in RPC proliferation and differentiation

Yuyao Wang
Dandan Zhang
Ping Gu
ResearchOpen Access18 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-15
A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency

Lili Gu
Yuling Sun
Zhigang Guo
ResearchOpen Access06 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-14
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals

Yanan Cao
Lin Li
Mengyao Wang
ResearchOpen Access30 Apr 2020
Cell Research

Volume: 30, P: 717-731
TCRP1 activated by mutant p53 promotes NSCLC proliferation via inhibiting FOXO3a

Hao Liu
Xiaoting Jia
Guopei Zheng
ResearchOpen Access22 Apr 2022
Oncogenesis

Volume: 11, P: 1-12
A quantum circuit simulator and its applications on Sunway TaihuLight supercomputer

Zhimin Wang
Zhaoyun Chen
Zhiqiang Wei
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-11
FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis

Ying Song
Shanshan Zeng
Hao Liu
ResearchOpen Access01 Dec 2020
Oncogene

Volume: 40, P: 777-790
Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress

Li Li
Zijun Su
Zhengtao Gu
ResearchOpen Access04 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-16
CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression

Dandan Zhang
Ni Ni
Xianqun Fan
ResearchOpen Access19 Aug 2020
Cell Death & Differentiation

Volume: 28, P: 283-302
Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

Hao Liu
Ying Song
Zhimin He
ResearchOpen Access11 Jul 2019
Cell Death & Differentiation

Volume: 27, P: 966-983
Endolysin LysEF-P10 shows potential as an alternative treatment strategy for multidrug-resistant Enterococcus faecalis infections

Mengjun Cheng
Yufeng Zhang
Jingmin Gu
ResearchOpen Access31 Aug 2017
Scientific Reports

Volume: 7, P: 1-15
The mechanisms behind heatstroke-induced intestinal damage

Minshu Sun
Qin Li
Li Li
ReviewsOpen Access28 Oct 2024
Cell Death Discovery

Volume: 10, P: 1-12
Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials

Yiqi Wang
Zhimin Tang
Ping Gu
ReviewsOpen Access23 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-14

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