Nature Search

In vivo base editing of Chd3 rescues behavioural abnormalities in mice

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

Kan Yang
Wei-Ke Li
Zilong Qiu
ResearchOpen Access18 Feb 2026
Nature

P: 1-11
A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Triacetic acid lactone (TAL) is a platform chemical with a wide range of applications. Here, the authors report the discovery of a polyketoacyl-CoA thiolase from Burkholderia sp. RF2-non_BP3, termed as BktBbr, which has unusually high in vivo and in vitro activity for production of TAL.

Zilong Wang
Seokjung Cheong
Jay D. Keasling
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-12
Optical focal plane based on MEMS light lead-in for geometric camera calibration

Jin Li
Zilong Liu
ResearchOpen Access06 Nov 2017
Microsystems & Nanoengineering

Volume: 3, P: 1-7
Single-cell transcriptomics identifies fibroblast associated immune heterogeneity and prognostic signatures in bladder cancer

Xiaojuan Tang
Ling Liu
Yan Tan
ResearchOpen Access03 Feb 2026
Scientific Reports

Volume: 16, P: 1-16
High-power performance enhancement in PZT-based piezoceramics via hot-pressing

The authors show that hot-pressing markedly improves high-power performance. In the hot-pressing process, the combined effect of applied pressure and sintering aids reduces the sintering temperature, which not only minimizes lead volatilization but also promotes densification.

Wan-Ting Cao
Ze Xu
Ke Wang
ResearchOpen Access05 Nov 2025
Nature Communications

Volume: 16, P: 1-8
Light-driven C–H activation mediated by 2D transition metal dichalcogenides

C–H activation in long-chain organic molecules remains largely unexplored. Here, the authors report light-driven C–H activation mediated by 2D TMDCs and the resultant synthesis of luminescent carbon dots.

Jingang Li
Di Zhang
Yuebing Zheng
ResearchOpen Access02 Jul 2024
Nature Communications

Volume: 15, P: 1-7
Scalable secondary metabolite production in Streptomyces using a plug-and-play system

A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces.

Bowen Yang
Zilong Li
Weishan Wang
Research15 Aug 2025
Nature Biotechnology

P: 1-13
Analysis and prediction of schizophrenia patients based on high-order graph attention generative adversarial networks

Guimei Yin
Mengzhen Yin
Shuping Tan
ResearchOpen Access03 Feb 2026
Scientific Reports

Volume: 16, P: 1-10
Publisher Correction: Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

Weishan Wang
Shanshan Li
Lixin Zhang
Amendments and Corrections18 Dec 2019
Nature Biotechnology

Volume: 38, P: 109
Erratum: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Shuai Wang
Sen Wang
Xuepeng Cai
Amendments and CorrectionsOpen Access03 Nov 2016
Nature Communications

Volume: 7, P: 1-2
Author Correction: High-yield porphyrin production through metabolic engineering and biocatalysis

Haihong Chen
Yaohong Wang
Lixin Zhang
Amendments and Corrections02 Jul 2024
Nature Biotechnology

Volume: 43, P: 1729
Dynamic regulation of TBK1 lactylation shapes antiviral immune responses

Yingchao Xie
Yufen Zhang
Xiao Yu
Research13 Jan 2026
Cellular & Molecular Immunology

P: 1-17
Carrier-envelope phase on-chip scanner and control of laser beams

Measurement and control of the carrier-envelope phase (CEP) is essential for applications of few-cycle laser beams. The authors present a compact on-chip, ambient-air, CEP scanning probe and show a 3D map of spatial changes of CEP and demonstrate CEP control in the focal volume with a spatial light modulator.

Václav Hanus
Beatrix Fehér
Péter Dombi
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-8
Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

Polyketide yields in Streptomyces are boosted by routing stored intracellular triacylglycerol into pathways that make industrially relevant products.

Weishan Wang
Shanshan Li
Lixin Zhang
Research09 Dec 2019
Nature Biotechnology

Volume: 38, P: 76-83
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

Bacterial allosteric transcription factors can sense and respond to a variety of small molecules. Here the authors present CaT-SMelor which uses Cas12a and allosteric transcription factors to detect small molecules in the nanomolar range.

Mindong Liang
Zilong Li
Li-Xin Zhang
ResearchOpen Access14 Aug 2019
Nature Communications

Volume: 10, P: 1-9
Imaging grain microstructure in a model ceramic energy material with optically generated coherent acoustic phonons

Optically generated acoustic phonons have enabled depth resolved microstructure characterization. Here, the authors extend this method to obtain information on the orientation of individual crystallites by studying influence of probe beam polarization on detected signal amplitude.

Yuzhou Wang
David H. Hurley
Marat Khafizov
ResearchOpen Access27 Mar 2020
Nature Communications

Volume: 11, P: 1-8
Solvent engineering for scalable fabrication of perovskite/silicon tandem solar cells in air

The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.

Xuntian Zheng
Wenchi Kong
Hairen Tan
ResearchOpen Access08 Jun 2024
Nature Communications

Volume: 15, P: 1-9
A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Thermophilic genetic manipulation tools are limited. Here the authors report a thermophilic type I-B CRISPR-Cas system and show it displays efficient transcriptional repression or DNA cleavage activity: they develop a tool for genome editing and transcriptional repression in both thermophile and mesophile hosts.

Zhiheng Yang
Zilong Li
Weishan Wang
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-14
Research on the rock cutting performance and feasibility verification of small-scale rotary cutting test for disc cutter

Zilong Yang
Yong Hu
Baicheng Zheng
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Oxidation-resistant all-perovskite tandem solar cells in substrate configuration

The superstate configuration in all-perovskite tandem solar cells is disadvantageous for long-term stability. Here, the authors reverse the processing order and demonstrate substrate configuration to bury oxidizable narrow-bandgap perovskites, and achieve efficiency of 25.3% with long stability.

Yurui Wang
Renxing Lin
Hairen Tan
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-11
High-yield porphyrin production through metabolic engineering and biocatalysis

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification.

Haihong Chen
Yaohong Wang
Lixin Zhang
Research05 Jun 2024
Nature Biotechnology

Volume: 43, P: 1717-1727
Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence

Cortical morphology shows maturation during childhood and adolescence. Here the authors show this is structurally constrained by a diffusion network model and that this constraint is linked to gene expression profiles of microstructural development.

Xinyuan Liang
Lianglong Sun
Yong He
ResearchOpen Access26 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase

Caixiu Huang
Hao Qiu
Xiaoyuan Hu
ResearchOpen Access08 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-15
Stochastic sizing and energy management of a hybrid energy system using cloud model and improved Walrus optimizer for China regions

Wenjun Liao
Qing Xiong
Hadi Gharoei
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-43
TadA orthologs enable both cytosine and adenine editing of base editors

Properties of cytidine and adenosine deaminases lead to off-target effects for cytosine base editors (CBEs) and adenine base editors (ABEs). Here the authors report that 25 TadA orthologs could be engineered to generate functional ABEs, CBEs or ACBEs via single/double mutations with minimised off-targets.

Shuqian Zhang
Bo Yuan
Tian-Lin Cheng
ResearchOpen Access26 Jan 2023
Nature Communications

Volume: 14, P: 1-10
Schizophrenia recognition based on three-dimensional adaptive graph convolutional neural network

Guimei Yin
Jie Yuan
Shuping Tan
ResearchOpen Access03 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Screening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX

Yuqian Long
Zhiqiang Qin
Weihong Tan
ResearchOpen Access28 Apr 2016
Scientific Reports

Volume: 6, P: 1-9
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Only one of the three Taenia species causing taeniasis in humans was previously sequenced. Here the authors provide draft genomes of Taenia saginata and Taenia asiatica, analyse genome evolution of all three species, and identify potential targets for developing diagnostic markers or intervention tools.

Shuai Wang
Sen Wang
Xuepeng Cai
ResearchOpen Access22 Sept 2016
Nature Communications

Volume: 7, P: 1-12
Development of a panel of DNA Aptamers with High Affinity for Pancreatic Ductal Adenocarcinoma

Carole Champanhac
I-Ting Teng
Weihong Tan
ResearchOpen Access25 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
The rubber tree genome reveals new insights into rubber production and species adaptation

A high-quality rubber tree genome reveals insights into the evolution of rubber biosynthesis and ethylene stimulation in rubber production. Together with transcriptome data, this study provides valuable data for the research and breeding of rubber trees.

Chaorong Tang
Meng Yang
Huasun Huang
ResearchOpen Access23 May 2016
Nature Plants

Volume: 2, P: 1-10
Error-Reduced Digital Elevation Model of the Qinghai-Tibet Plateau using ICESat-2 and Fusion Model

Xingang Zhang
Shanchuan Guo
Peijun Du
ResearchOpen Access05 Jun 2024
Scientific Data

Volume: 11, P: 1-18
PSMB2 plays an oncogenic role in glioma and correlates to the immune microenvironment

Wei He
Zhe Zhang
XinGen Zhu
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
Lightweight defect detection algorithm of tunnel lining based on knowledge distillation

Anfu Zhu
Jiaxiao Xie
Zhanping Yang
ResearchOpen Access08 Nov 2024
Scientific Reports

Volume: 14, P: 1-16
Reverse Chromatin Immunoprecipitation (R-ChIP) enables investigation of the upstream regulators of plant genes

Xuejing Wen et al. present a new method, Reverse Chromatin Immunoprecipitation (R-ChIP), for analyzing DNA-protein interactions specifically in plant cells. They apply R-ChIP to identify proteins binding to the promoter of the Arabidopsis gene AtCAT3 and optimize the method using transient transformation of the target promoter to increase efficiency.

Xuejing Wen
Jingxin Wang
Yucheng Wang
ResearchOpen Access14 Dec 2020
Communications Biology

Volume: 3, P: 1-12
Dietary patterns and the risk of rhinitis in primary school children: a prospective cohort study

Xudong Liu
Claudie Chiu-Yi Wong
Xiang Qian Lao
ResearchOpen Access15 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Phosphorous fertilization alleviates drought effects on Alnus cremastogyne by regulating its antioxidant and osmotic potential

Akash Tariq
Kaiwen Pan
Aiping Zhang
ResearchOpen Access04 Apr 2018
Scientific Reports

Volume: 8, P: 1-11

Search

In vivo base editing of Chd3 rescues behavioural abnormalities in mice

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Optical focal plane based on MEMS light lead-in for geometric camera calibration

Single-cell transcriptomics identifies fibroblast associated immune heterogeneity and prognostic signatures in bladder cancer

High-power performance enhancement in PZT-based piezoceramics via hot-pressing

Light-driven C–H activation mediated by 2D transition metal dichalcogenides

Scalable secondary metabolite production in Streptomyces using a plug-and-play system

Analysis and prediction of schizophrenia patients based on high-order graph attention generative adversarial networks

Publisher Correction: Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

Erratum: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Author Correction: High-yield porphyrin production through metabolic engineering and biocatalysis

Dynamic regulation of TBK1 lactylation shapes antiviral immune responses

Carrier-envelope phase on-chip scanner and control of laser beams

Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

Imaging grain microstructure in a model ceramic energy material with optically generated coherent acoustic phonons

Solvent engineering for scalable fabrication of perovskite/silicon tandem solar cells in air

A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Research on the rock cutting performance and feasibility verification of small-scale rotary cutting test for disc cutter

Oxidation-resistant all-perovskite tandem solar cells in substrate configuration

High-yield porphyrin production through metabolic engineering and biocatalysis

Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence

Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase

Stochastic sizing and energy management of a hybrid energy system using cloud model and improved Walrus optimizer for China regions

TadA orthologs enable both cytosine and adenine editing of base editors

Schizophrenia recognition based on three-dimensional adaptive graph convolutional neural network

Human lifespan changes in the brain’s functional connectome

Screening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX

Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Development of a panel of DNA Aptamers with High Affinity for Pancreatic Ductal Adenocarcinoma

The rubber tree genome reveals new insights into rubber production and species adaptation

Error-Reduced Digital Elevation Model of the Qinghai-Tibet Plateau using ICESat-2 and Fusion Model

PSMB2 plays an oncogenic role in glioma and correlates to the immune microenvironment

Lightweight defect detection algorithm of tunnel lining based on knowledge distillation

Reverse Chromatin Immunoprecipitation (R-ChIP) enables investigation of the upstream regulators of plant genes

Dietary patterns and the risk of rhinitis in primary school children: a prospective cohort study

Phosphorous fertilization alleviates drought effects on Alnus cremastogyne by regulating its antioxidant and osmotic potential

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