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N-acetyltransferase 10 (NAT10) is an N⁴‐acetylcytidine (ac⁴C) writer, which catalyzes RNA acetylation at cytidine N⁴ position on RNAs. Here, the authors show that NAT10 catalyzes ac⁴C addition to a long non-coding RNA encoded by the oncogenic DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV), triggering viral lytic reactivation from latency, which promotes NAT10 recruitment of IFI16 mRNA, resulting in inflammasome activation.

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Absorption and accumulation of atmospheric microplastics by plant leaves occurs widely in the environment.

The development of ion-solvating membranes with low ion resistance and high ion selectivity remains a challenge in the field of electrochemical energy conversion and storage. Here the authors report that watermelon skin ion-solvating membrane exhibits high ion conductivity and high ion selectivity.

Ma et al. profile the dynamic landscape of m⁶A during pancreatic differentiation, and identify ALKBH5 as an essential m⁶A regulator supporting pancreatic differentiation, indicating a role for m⁶A-mediated mRNA metabolism in cell-fate specification.

Single-cell transcriptomes and single-cell chromatin accessibility profiles generated using EasySci provide a global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics in human and mouse brains.

Large potentials required for C(sp³)-H bond activation and low water solubility make electrochemical functionalization of alkanes challenging. Here, the authors report that Pt/IrO_x enables selective generation of Cl free radicals for chlorination of cyclohexane at industrially relevant rates.

Chen et al. develop a fast chemical reprogramming system that promotes the transition towards pluripotency through a unique diapause-like state.

DNA methylation data of whole blood from Han Chinese individuals are used to map mQTLs, finding that cis- and trans-mQTLs show distinct patterns of East Asians (EA) ancestry-specific colocalization with complex trait variation.

An erbium(III)–bacteriochlorin probe with large Stokes shift and efficient near-infrared to near-infrared energy conversion enables multiplexed imaging of deep tissues in living animals.

Understanding antibody responses to Sars-CoV-2 proteins over time is complicated by many variables. Here the authors survey IgM and IgG antibodies against S protein, RBD and nucleoprotein in a large cohort of infected and recovering severe vs. moderate COVID-19 patients, comparing against clinical parameters and immunological readouts.

Through inelastic light scattering chiral spin-2 long-wavelength magnetorotons are observed, revealing chiral graviton modes in fractional quantum Hall states and aiding in understanding the quantum metric impacts in topological correlated systems.

Smart monitoring devices with integrated mechanical protection and piezoelectric induction are limited. Here, the authors report a strategy to grow piezoelectric Rochelle salt crystals in 3D-printed cuttlebone-inspired structures to produce smart monitoring devices with integrated mechanical protection and electrical sensing capability.

Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients.

YTHDF1 is an m6A reader that binds to methylated RNA and facilitates translation. Here the authors show that tumor intrinsic YTHDF1 promotes tumorigenesis by regulating lysosomal proteolysis of MHC-I and that YTHDF1 targeting boosts anti-tumor immunity and response to immunotherapy in preclinical cancer models.

A genome-wide study based on three-dimensional facial images identifies new loci associated with facial morphology in East Asian populations. Comparison with data from European populations identifies variants related to facial shape differences between these populations.

Evidence for a quantum magnetic analogue of a supersolid appears in a recently synthesized antiferromagnet showing a strong magnetocaloric effect of the spin supersolid phase with potential for applications in sub-kelvin refrigeration.

The concurrent depletion of tumour cells and immunosuppressive cells via a monoclonal antibody targeting a common surface marker prevents tumours from acquiring resistance to therapies involving immune checkpoint blockade.

Controlled tuning of surface adhesion is crucial to a broad range of applications. By simply introducing a mechanical micro-vibration, Shui et al. discover that the surface adhesion can be either enhanced by orders of magnitude or weakened to zero with a switching rate at millisecond timescale.

To achieve efficient photocatalytic non-oxidative methane coupling, a strong polarization environment with abundant activation sites for C-H scissoring is needed. This can be created through the fabrication of high-density frustrated Lewis pairs on lamellar Nb₂O₅ using a thermal-reduction promoted phase-transition process.

Carbon-based electrodes able to intercalate Li⁺ and Na⁺ ions have been exploited for high performing energy storage devices. Here, the authors combine the ion intercalation properties of porous graphitic carbons with the redox chemistry of iodine to produce iodine–carbon batteries with high reversible capacities.

Stereoregular polymers exhibit improved thermal and mechanical properties, making the development of enantioselective polymerization catalysts of significant importance. Here, the authors summarize catalyst design strategies and synthetic routes for enantioselective polymerizations of degradable or recyclable polymers from racemic monomers.

This Perspective examines the development of safe, secure and trustworthy compute-in-memory accelerators, exploring vulnerabilities specific to such accelerators and discussing the security opportunities of the systems.

Enhancing deformation of soft microparticles such as cells, capsules and vesicles has widespread applications in cell phenotyping, drug/gene delivery and smart material synthesis. Here, the authors demonstrate that enclosing a capsule into a droplet can amplify the capsule deformation parameter by up to two orders of magnitude, compared with an isolated capsule experiencing identical channel flow conditions.

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

We explore and observe the spatio-temporal breather dynamics of optical soliton frequency comb crystals, examining spatial breathers, chaos transitions, and dynamical switching – in nonlinear measurements and theory.