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The effect of different nutritional feeds on the postprandial glucose response in healthy volunteers and patients with type II diabetes

European Journal of Clinical Nutrition volume 58, pages 1553–1556 (2004)Cite this article

Abstract

Objective: Assessment of postprandial glycaemic response to four nutritional feeds with different macronutrient and fibre composition.

Design: A randomized, double-blind, crossover study.

Setting: University of Maastricht, the Netherlands.

Subjects: A total of 10 healthy volunteers and 10 patients with type II diabetes.

Interventions: Subjects received 200 kcal of four enteral nutrition products (two standard products and two diabetes-specific products). Fasting and postprandial plasma glucose were measured for 2 h. Peak glucose level and area under the curve were calculated.

Results: In healthy volunteers and diabetic patients, the feed with a low carbohydrate (CHO), high monounsaturated fatty acid (MUFA) and high fibre content significantly decreased peak glucose concentration and area under the curve compared to the feeds with standard composition.

Conclusions: Special feeds with a low CHO, high MUFA and high fibre content improve glycaemic balance and therefore should be considered in diabetic patients who are in need of nutritional support.

Sponsorship: Numico Research BV, The Netherlands.

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Acknowledgements

We thank all volunteers for their participation and G van Kranenburg for his technical assistance. Royal Numico NV sponsored the study and supplied the nutritional products.

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Authors and Affiliations

  1. Numico Research BV, Wageningen, The Netherlands

    Z Hofman & J D E van Drunen

  2. Maastricht University, Maastricht, The Netherlands

    C de Later & H Kuipers

Authors
  1. Z Hofman
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  2. J D E van Drunen
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  3. C de Later
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  4. H Kuipers
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Contributions

Guarantor: Z Hofman.

Contributors: Protocol design: ZH, JDEvD and HK, Data analysis: ZH and JDEvD. Manuscript preparation: ZH, JDEvD and HK. Subject inclusion: CdL and HK. Data collection: CdL and HK.

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Correspondence to Z Hofman.

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Hofman, Z., van Drunen, J., de Later, C. et al. The effect of different nutritional feeds on the postprandial glucose response in healthy volunteers and patients with type II diabetes. Eur J Clin Nutr 58, 1553–1556 (2004). https://doi.org/10.1038/sj.ejcn.1602007

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