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Moderate increase in dietary sucrose does not influence fasting or postprandial serum lipids regardless of the presence of apolipoprotein E2 allele in healthy subjects

European Journal of Clinical Nutrition volume 61, pages 1094–1101 (2007)Cite this article

Abstract

Objective:

To investigate whether a moderate increase in dietary sucrose intake induces different serum lipid responses in normolipidemic subjects with the ɛ2 allele compared with subjects without the ɛ2 allele.

Design:

Controlled, parallel study.

Subjects:

There were 15 subjects with the apolipoprotein E (APOE)3/2 genotype and 19 subjects with the APOE3/3 or 3/4 genotype, whose mean±s.d. age was 48±14 and 35±10 years, respectively. All subjects had normal glucose metabolism.

Interventions:

The subjects were instructed to increase their sucrose intake by 40 g/day for 8 weeks and to decrease the intake of saturated and unsaturated fat to maintain energy balance. Dietary adherence was monitored using food records and the actual increase in sucrose intake was 39.8±18.4 g/day. Sixteen subjects (nine with APOE3/2 genotype, seven with APOE3/3 or 3/4 genotypes) participated also in an 8 h oral fat tolerance test at the beginning and at the end of the intervention.

Results:

Body weight remained stable during the intervention. Sucrose intake did not have a significant effect on fasting concentrations of serum total and lipoprotein lipids, plasma glucose, serum insulin, squalene and non-cholesterol sterols in either genotype group. Neither were there any changes in postprandial lipid or insulin responses.

Conclusions:

Moderate increase in sucrose intake does not affect fasting or postprandial serum lipid responses in healthy subjects with or without the ɛ2 allele.

Sponsorship:

Academy of Finland (projects 80232, 200801) and Yrjö Jahnsson Foundation.

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Acknowledgements

The study was financially supported by Academy of Finland (projects 80232, 200801) and Yrjö Jahnsson Foundation.We thank medical laboratory technologists Erja Kinnunen, Kaija Kettunen and Päivi Turunen for their skillful work and Kristiina Nyyssönen, PhD for significant help in recruitment of study subjects.

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Authors and Affiliations

  1. School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland

    A T Erkkilä, U S Schwab, M Hallikainen, H Gylling & M I J Uusitupa

  2. Research Center on Health Effects of Foods, Kuopio, Finland

    U S Schwab & M I J Uusitupa

  3. Department of Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland

    U S Schwab & H Gylling

  4. Department of Physiology, University of Kuopio, Kuopio, Finland

    J J Ågren

Authors
  1. A T Erkkilä
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  2. U S Schwab
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  3. J J Ågren
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  4. M Hallikainen
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  5. H Gylling
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  6. M I J Uusitupa
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Corresponding author

Correspondence to A T Erkkilä.

Additional information

Guarantors: AT Erkkilä and MIJ Uusitupa.

Contributors: ATE, USS and MIJU designed the study. ATE and USS were responsible for formulation of dietary interventions, participant contact during the intervention, analyses of food records and statistical analyses. MH and HG supervised analyses of squalene and non-cholesterol sterols. JJÅ was responsible for the postprandial tests and related data analyses. ATE wrote the paper. All authors contributed to data interpretation and revision of the paper.

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Erkkilä, A., Schwab, U., Ågren, J. et al. Moderate increase in dietary sucrose does not influence fasting or postprandial serum lipids regardless of the presence of apolipoprotein E2 allele in healthy subjects. Eur J Clin Nutr 61, 1094–1101 (2007). https://doi.org/10.1038/sj.ejcn.1602620

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