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PBSC autotransplant for inflammatory bowel disease (IBD): a case of ulcerative colitis

Bone Marrow Transplantation volume 28, pages 109–110 (2001)Cite this article

We read the interesting article by Musso et al1 concerning a case of Crohn's disease with a 3 year complete treatment-free remission after unmanipulated autologous stem cell transplantation performed for relapsed extranodal Hodgkin's lymphoma.

Allogeneic transplantation is commonly performed for haematological malignancies, and allows observation of patients with IBD who appear to enter long-term remission after transplantation. With a lower transplant-related mortality, PBSC autotransplant has been reported to be feasible and to improve the natural history of severe autoimmune diseases in some case reports.2 Two cases of clinical remission of Crohn's disease with 7 and 3 years follow-up after PBSC autotransplant for a coincidental malignancy have been reported. One case with ulcerative colitis (UC) undergoing a PBSC autotransplant for a high-risk breast cancer has been reported.3 This patient had mild left-sided inflammation in the pretransplant colonoscopy and was asymptomatic, off medication 2 years after transplant. At our institution we have had a recent experience concerning a patient diagnosed with UC.

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References

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  1. Oncologia Medica, Hospital General Alicante, Maestro Alonso, 109, Alicante, 03010, Spain

    JL Martí, JI Mayordomo, MD Isla, A Saenz, P Escudero & A Tres

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  1. JL Martí
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  2. JI Mayordomo
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  3. MD Isla
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  4. A Saenz
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Martí, J., Mayordomo, J., Isla, M. et al. PBSC autotransplant for inflammatory bowel disease (IBD): a case of ulcerative colitis. Bone Marrow Transplant 28, 109–110 (2001). https://doi.org/10.1038/sj.bmt.1703103

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