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T-cell post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: another case and a review of the literature

Bone Marrow Transplantation volume 34, pages 821–822 (2004)Cite this article

Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication after solid organ and hematopoietic stem cell transplantations (HSCT). The majority are of B-cell origin and Epstein–Barr virus (EBV) related.1 PTLD of T-cell origin have also been described after solid organ transplantations, but are mostly unrelated to EBV infection. After allogeneic HSCT, three cases of T-cell PTLD have been reported.2 Recently, two cases of T-cell PTLD following autologous HSCT were described.3, 4 We report another case of T-cell PTLD after autologous HSCT in a patient with nonsecretory multiple myeloma (MM).

A 68-year-old man presented with worsening back pain. Physical examination showed no lymphadenopathy or hepatosplenomegaly. Initial investigations revealed anemia, thrombocytopenia, hypercalcemia, renal impairment, multiple vertebral compression fractures and immune paresis without detectable serum monoclonal bands and urine light chains. The bone marrow (BM) was replaced by malignant plasma cells and stage IIIB nonsecretory MM was diagnosed. He was commenced on the VAD (vincristine, adriamycin and dexamethasone) regimen.

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References

  1. Loren AW, Porter DL, Stadtmauer EA, Tsai DE . Post-transplant lymphoproliferative disorder: a review. Leukemia 2003; 31: 145–155.

    CAS  Google Scholar 

  2. Zutter MM, Durnam DM, Hackman RC et al. Secondary T-cell lymphoproliferation after marrow transplantation. Am J Clin Pathol 1990; 94: 714–721.

    Article  CAS  Google Scholar 

  3. Yufu Y, Kimura M, Kawano R et al. Epstein–Barr virus-associated T cell lymphoproliferative disorder following autologous blood stem cell transplantation for relapsed Hodgkin's disease. Bone Marrow Transplant 2000; 26: 1339–1341.

    Article  CAS  Google Scholar 

  4. Narumi H, Kojima K, Matsuo Y et al. T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2004; 33: 99–101.

    Article  CAS  Google Scholar 

  5. Curtis RE, Travis LB, Rowlings PA et al. Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. Blood 1999; 94: 2208–2216.

    CAS  Google Scholar 

  6. Lones MA, Kirov I, Said JW et al. Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient. Bone Marrow Transplant 2000; 26: 1021–1024.

    Article  CAS  Google Scholar 

  7. Jenkins D, DiFrancesco L, Chaudhry A et al. Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients. Bone Marrow Transplant 2002; 30: 321–326.

    Article  CAS  Google Scholar 

  8. Sze DMY, Glesajtis G, Brown RD et al. Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+CD57+CD28− compartment. Blood 2001; 98: 2817–2827.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Haematology-Oncology, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    L G Lau

  2. Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    L K Tan & T C Liu

  3. Molecular Diagnostic Centre, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    M Salto-Tellez & E S C Koay

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  1. L G Lau
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  2. L K Tan
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  3. M Salto-Tellez
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  4. E S C Koay
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  5. T C Liu
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Lau, L., Tan, L., Salto-Tellez, M. et al. T-cell post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: another case and a review of the literature. Bone Marrow Transplant 34, 821–822 (2004). https://doi.org/10.1038/sj.bmt.1704677

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